JPWO2020158914A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020158914A5 JPWO2020158914A5 JP2020568624A JP2020568624A JPWO2020158914A5 JP WO2020158914 A5 JPWO2020158914 A5 JP WO2020158914A5 JP 2020568624 A JP2020568624 A JP 2020568624A JP 2020568624 A JP2020568624 A JP 2020568624A JP WO2020158914 A5 JPWO2020158914 A5 JP WO2020158914A5
- Authority
- JP
- Japan
- Prior art keywords
- molecules
- dendritic cells
- cell population
- regulatory dendritic
- cd300c
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 14
- 210000004443 dendritic cell Anatomy 0.000 claims 14
- 230000001105 regulatory effect Effects 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 7
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 7
- -1 CD300c Proteins 0.000 claims 7
- 102100032912 CD44 antigen Human genes 0.000 claims 7
- 102000024905 CD99 Human genes 0.000 claims 7
- 108060001253 CD99 Proteins 0.000 claims 7
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims 7
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 7
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 7
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 7
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 7
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims 7
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 7
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 claims 7
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 7
- 101000576894 Homo sapiens Macrophage mannose receptor 1 Proteins 0.000 claims 7
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 7
- 101000795107 Homo sapiens Triggering receptor expressed on myeloid cells 1 Proteins 0.000 claims 7
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 7
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 7
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 7
- 102100025354 Macrophage mannose receptor 1 Human genes 0.000 claims 7
- 102100029216 SLAM family member 5 Human genes 0.000 claims 7
- 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 claims 7
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (13)
- 制御性樹状細胞を検出する方法であって、以下の工程：
工程ａ：制御性樹状細胞を含む細胞集団において、細胞の表面上の1種以上の分子の存在又は非存在を検出する工程、及び
工程ｂ：該1種以上の分子の存在又は非存在に基づき制御性樹状細胞を同定する工程
を含み、前記1種以上の分子が、CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される少なくとも1種の分子である、方法。 - 前記1種以上の分子が、CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される2種以上の分子である、請求項１に記載の方法。
- 前記制御性樹状細胞を含む細胞集団が、多能性幹細胞を分化誘導することにより得られる細胞集団である、請求項１又は２に記載の方法。
- 前記多能性幹細胞が、ヒト人工多能性幹細胞である、請求項３に記載の方法。
- 制御性樹状細胞が富化された細胞集団を製造する方法であって、以下の工程：
工程１：制御性樹状細胞を含む細胞集団において、細胞の表面上の1種以上の分子の存在又は非存在を検出する工程、及び
工程２：該1種以上の分子の存在又は非存在に基づき制御性樹状細胞が富化された細胞集団を得る工程
を含む方法。 - 前記1種以上の分子が、CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される少なくとも1種の分子である、請求項５に記載の方法。
- 前記1種以上の分子が、CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される2種以上の分子である、請求項５に記載の方法。
- 制御性樹状細胞を富化する方法であって、以下の工程：
工程Ａ：制御性樹状細胞を含む細胞集団において、細胞の表面上の1種以上の分子の存在又は非存在を検出する工程、及び
工程Ｂ：該1種以上の分子の存在又は非存在に基づき制御性樹状細胞を選択する工程
を含む方法。 - 請求項５～８のいずれか一項に記載の方法により得られる制御性樹状細胞が富化された細胞集団。
- CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される少なくとも1種以上の分子を発現する、又は発現しない制御性樹状細胞が富化された細胞集団。
- CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される2種以上の分子を発現する、又は発現しない制御性樹状細胞が富化された細胞集団。
- CD99、CD183、CD107a、CD366、CD172a、CD200R、CD44、CD206、CD181、CD354、CD300c、CD50及びCD84からなる群から選択される少なくとも1種の分子の各々に対する抗体を含む、制御性樹状細胞の検出用試薬。
- 請求項９～１１のいずれか一項に記載の制御性樹状細胞が富化された細胞集団を含む、医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019017293 | 2019-02-01 | ||
| JP2019017293 | 2019-02-01 | ||
| PCT/JP2020/003628 WO2020158914A1 (ja) | 2019-02-01 | 2020-01-31 | 細胞の検出方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2020158914A1 JPWO2020158914A1 (ja) | 2021-12-02 |
| JPWO2020158914A5 true JPWO2020158914A5 (ja) | 2023-02-03 |
Family
ID=71840303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568624A Pending JPWO2020158914A1 (ja) | 2019-02-01 | 2020-01-31 | 細胞の検出方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220099670A1 (ja) |
| EP (1) | EP3919124A4 (ja) |
| JP (1) | JPWO2020158914A1 (ja) |
| CN (1) | CN113382768A (ja) |
| TW (1) | TW202045718A (ja) |
| WO (1) | WO2020158914A1 (ja) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1705439A (zh) * | 2002-04-12 | 2005-12-07 | 细胞基因公司 | 干细胞和祖细胞分化的调节、鉴定及其应用 |
| AU2003237416A1 (en) * | 2002-06-04 | 2003-12-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Novel tolerogenic dendritic cells and therapeutic uses therefor |
| JP2005080528A (ja) * | 2003-09-05 | 2005-03-31 | Shuichi Uenokawa | Ｉｌ−１０を高産生する細胞およびその製造方法 |
| MX2008007654A (es) | 2005-12-13 | 2008-09-26 | Univ Kyoto | Factor de reprogramacion nuclear. |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US7661738B2 (en) | 2006-11-28 | 2010-02-16 | Veritainer Corporation | Radiation detection unit for mounting a radiation sensor to a container crane |
| US8236579B2 (en) | 2007-03-14 | 2012-08-07 | Taiwan Semiconductor Manufacturing Company, Ltd. | Methods and systems for lithography alignment |
| WO2008124133A1 (en) | 2007-04-07 | 2008-10-16 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
| CN101802172A (zh) | 2007-05-30 | 2010-08-11 | 通用医疗公司 | 由体细胞产生多能细胞的方法 |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| WO2011049053A1 (ja) * | 2009-10-20 | 2011-04-28 | 国立大学法人大阪大学 | Ｔ細胞活性化を抑制する腸粘膜特有のミエロイド細胞およびその利用 |
| SG11201610200RA (en) * | 2014-06-05 | 2017-01-27 | Pontificia Universidad Católica De Chile | Method for producing tolerogenic dendritic cells with specific antigens and uses thereof |
| EA201790883A1 (ru) * | 2014-10-22 | 2018-02-28 | Сотио А.С. | Толерогенные дендритные клетки, способы их получения и их применения |
| CN109415699A (zh) | 2016-06-23 | 2019-03-01 | 国立大学法人京都大学 | Cd4cd8双阳性t细胞的制备方法 |
-
2020
- 2020-01-31 JP JP2020568624A patent/JPWO2020158914A1/ja active Pending
- 2020-01-31 CN CN202080011888.2A patent/CN113382768A/zh active Pending
- 2020-01-31 WO PCT/JP2020/003628 patent/WO2020158914A1/ja unknown
- 2020-01-31 TW TW109103045A patent/TW202045718A/zh unknown
- 2020-01-31 EP EP20747635.9A patent/EP3919124A4/en active Pending
-
2021
- 2021-01-31 US US17/427,222 patent/US20220099670A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mareš et al. | Taxonomic resolution of the genus Cyanothece (Chroococcales, Cyanobacteria), with a treatment on Gloeothece and three new genera, Crocosphaera, Rippkaea, and Zehria | |
| Quan et al. | A re-evaluation of the Chaetothyriales using criteria of comparative biology | |
| Miettinen et al. | Comprehensive taxon sampling reveals unaccounted diversity and morphological plasticity in a group of dimitic polypores (Polyporales, Basidiomycota) | |
| Krivoshapkin et al. | Between denisovans and neanderthals: Strashnaya Cave in the Altai mountains | |
| Birkeland et al. | Transcriptome analyses of the Giardia lamblia life cycle | |
| Minervina et al. | Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones | |
| Hemphill et al. | Horse‐mounted invaders from the Russo‐Kazakh steppe or agricultural colonists from western Central Asia? A craniometric investigation of the Bronze Age settlement of Xinjiang | |
| Wu et al. | The white-rotting genus Phanerochaete is polyphyletic and distributed throughout the phleboid clade of the Polyporales (Basidiomycota) | |
| Maier et al. | Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation | |
| Song et al. | Species delimitation and phylogenetic reconstruction of the sinipercids (Perciformes: Sinipercidae) based on target enrichment of thousands of nuclear coding sequences | |
| Gontcharov | Phylogeny and classification of Zygnematophyceae (Streptophyta): current state of affairs | |
| Li et al. | Two new Fomitopsis species from southern China based on morphological and molecular characters | |
| Chai et al. | New and noteworthy boletes from subtropical and tropical China | |
| Bar-Yosef | Neanderthals and modern humans across Eurasia | |
| Guimarey et al. | Secular changes in body size and body composition in schoolchildren from La Plata City (Argentina) | |
| Liu et al. | Species diversity, molecular phylogeny and ecological habits of Cyanosporus (Polyporales, Basidiomycota) with an emphasis on Chinese collections | |
| Zhou et al. | Two new species of Hymenochaetaceae from tropical Asia and America | |
| JPWO2020158914A5 (ja) | ||
| Alekseev et al. | Some problems in the study of the chronology of the ancient nomadic cultures in Eurasia (9th-3rd centuries BC) | |
| Oppenheimer et al. | mtDNA variation and southward Holocene human dispersals within mainland Southeast Asia | |
| Lin et al. | The potential fungal pathogens of Euonymus japonicus in Beijing, China | |
| Zhao et al. | Leifiporia rhizomorpha gen. et sp. nov. and L. eucalypti comb. nov. in Polyporaceae (Basidiomycota) | |
| Césari et al. | First report of permineralised plants in the Stephanian of Arnao (Asturias, northwestern Spain) | |
| Martínez Sánchez et al. | Reflections on the other side. A Southern Iberia origin for the first pottery production of Northern Morocco? | |
| Cao et al. | Multiple-marker phylogeny and morphological evidence reveal two new species in Steccherinaceae (Polyporales, Basidiomycota) from Asia |