JPWO2020154437A5 - - Google Patents
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- Publication number
- JPWO2020154437A5 JPWO2020154437A5 JP2021542159A JP2021542159A JPWO2020154437A5 JP WO2020154437 A5 JPWO2020154437 A5 JP WO2020154437A5 JP 2021542159 A JP2021542159 A JP 2021542159A JP 2021542159 A JP2021542159 A JP 2021542159A JP WO2020154437 A5 JPWO2020154437 A5 JP WO2020154437A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- aryl
- heterocyclyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 44
- 125000001072 heteroaryl group Chemical group 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000003107 substituted aryl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 22
- 125000003342 alkenyl group Chemical group 0.000 claims 19
- 125000000304 alkynyl group Chemical group 0.000 claims 19
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 19
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 15
- -1 amino, substituted amino, carboxyl Chemical group 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 11
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 10
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000005309 thioalkoxy group Chemical group 0.000 claims 8
- 125000004442 acylamino group Chemical group 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 6
- 229930182470 glycoside Natural products 0.000 claims 5
- 150000002338 glycosides Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical group 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 125000004036 acetal group Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 150000002019 disulfides Chemical class 0.000 claims 2
- 125000003916 ethylene diamine group Chemical group 0.000 claims 2
- 150000002429 hydrazines Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960005501 duocarmycin Drugs 0.000 claims 1
- 229930184221 duocarmycin Natural products 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024151730A JP2024170512A (ja) | 2019-01-23 | 2024-09-03 | 抗体－薬物コンジュゲート用のグリコシド含有ペプチドリンカー |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962795875P | 2019-01-23 | 2019-01-23 | |
| US62/795,875 | 2019-01-23 | ||
| PCT/US2020/014658 WO2020154437A1 (en) | 2019-01-23 | 2020-01-22 | Glycoside-containing peptide linkers for antibody-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024151730A Division JP2024170512A (ja) | 2019-01-23 | 2024-09-03 | 抗体－薬物コンジュゲート用のグリコシド含有ペプチドリンカー |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022518743A JP2022518743A (ja) | 2022-03-16 |
| JPWO2020154437A5 true JPWO2020154437A5 (https=) | 2023-01-31 |
| JP2022518743A5 JP2022518743A5 (https=) | 2023-01-31 |
| JP7550768B2 JP7550768B2 (ja) | 2024-09-13 |
Family
ID=71736993
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542159A Active JP7550768B2 (ja) | 2019-01-23 | 2020-01-22 | 抗体－薬物コンジュゲート用のグリコシド含有ペプチドリンカー |
| JP2024151730A Pending JP2024170512A (ja) | 2019-01-23 | 2024-09-03 | 抗体－薬物コンジュゲート用のグリコシド含有ペプチドリンカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024151730A Pending JP2024170512A (ja) | 2019-01-23 | 2024-09-03 | 抗体－薬物コンジュゲート用のグリコシド含有ペプチドリンカー |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220226490A1 (https=) |
| EP (1) | EP3914262A4 (https=) |
| JP (2) | JP7550768B2 (https=) |
| KR (1) | KR20210119450A (https=) |
| CN (3) | CN113874046B (https=) |
| AU (1) | AU2020210919B2 (https=) |
| CA (1) | CA3127098A1 (https=) |
| WO (1) | WO2020154437A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113874046B (zh) * | 2019-01-23 | 2025-02-28 | R.P.谢勒技术有限责任公司 | 用于抗体-药物缀合物的含有糖苷的肽接头 |
| CN116783208A (zh) * | 2020-11-20 | 2023-09-19 | R.P.谢勒技术有限责任公司 | 用于抗体-药物缀合物的糖苷双裂解接头 |
| KR20230122008A (ko) * | 2020-11-20 | 2023-08-22 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 항체-약물 접합체를 위한 글리코시드 이중-절단 링커 |
| WO2022155362A1 (en) * | 2021-01-15 | 2022-07-21 | R.P. Scherer Technologies, Llc | Dual-cleavage ester linkers for antibody-drug conjugates |
| AU2022207454A1 (en) * | 2021-01-15 | 2023-06-22 | R.P. Scherer Technologies, Llc | Camptothecine antibody-drug conjugates and methods of use thereof |
| EP4297798A4 (en) * | 2021-02-25 | 2025-11-12 | Allygen Group | Targeting Conjugates Comprising Effector Molecules and Their Uses |
| EP4301415A4 (en) * | 2021-03-03 | 2026-03-18 | Scherer Technologies Llc R P | Branched-Cell Networks for Antibody-Drug Conjugates and Their Methods of Use |
| WO2023009759A2 (en) * | 2021-07-30 | 2023-02-02 | R.P. Scherer Technologies, Llc | Antibody-drug conjugates and methods of use thereof |
| JP2026500913A (ja) | 2022-12-13 | 2026-01-09 | クリネティックス ファーマシューティカルズ，インク． | ソマトスタチンサブタイプ－２受容体（ｓｓｔ２ｒ）標的化治療薬及びその使用 |
| AR132368A1 (es) | 2023-04-18 | 2025-06-18 | Astrazeneca Ab | Conjugados que comprenden enlazadores escindibles |
| TW202525851A (zh) * | 2023-08-15 | 2025-07-01 | 瑞典商阿斯特捷利康公司 | 包含可切割連接子的軛合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014176284A1 (en) * | 2013-04-22 | 2014-10-30 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
| WO2015081282A1 (en) * | 2013-11-27 | 2015-06-04 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
| KR102783230B1 (ko) * | 2015-11-09 | 2025-03-19 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 항-cd22 항체-메이탄신 콘쥬게이트 및 그것의 사용 방법 |
| US10195283B2 (en) * | 2016-03-18 | 2019-02-05 | R.P. Scherer Technologies, Llc | Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate |
| CA3063325A1 (en) * | 2017-06-21 | 2018-12-27 | Glykos Finland Oy | Hydrophilic linkers and conjugates thereof |
| WO2019113248A1 (en) * | 2017-12-07 | 2019-06-13 | The Regents Of The University Of California | Anti-upar antibody-drug conjugates and methods of use thereof |
| CN113874046B (zh) * | 2019-01-23 | 2025-02-28 | R.P.谢勒技术有限责任公司 | 用于抗体-药物缀合物的含有糖苷的肽接头 |
-
2020
- 2020-01-22 CN CN202080013223.5A patent/CN113874046B/zh active Active
- 2020-01-22 WO PCT/US2020/014658 patent/WO2020154437A1/en not_active Ceased
- 2020-01-22 CA CA3127098A patent/CA3127098A1/en active Pending
- 2020-01-22 US US17/423,796 patent/US20220226490A1/en active Pending
- 2020-01-22 CN CN202510154419.0A patent/CN119896745A/zh active Pending
- 2020-01-22 KR KR1020217026304A patent/KR20210119450A/ko active Pending
- 2020-01-22 EP EP20744386.2A patent/EP3914262A4/en active Pending
- 2020-01-22 JP JP2021542159A patent/JP7550768B2/ja active Active
- 2020-01-22 CN CN202510154420.3A patent/CN119896746A/zh active Pending
- 2020-01-22 AU AU2020210919A patent/AU2020210919B2/en active Active
-
2024
- 2024-09-03 JP JP2024151730A patent/JP2024170512A/ja active Pending
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