JPWO2020154402A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020154402A5 JPWO2020154402A5 JP2020572967A JP2020572967A JPWO2020154402A5 JP WO2020154402 A5 JPWO2020154402 A5 JP WO2020154402A5 JP 2020572967 A JP2020572967 A JP 2020572967A JP 2020572967 A JP2020572967 A JP 2020572967A JP WO2020154402 A5 JPWO2020154402 A5 JP WO2020154402A5
- Authority
- JP
- Japan
- Prior art keywords
- cfdna
- copy number
- cell
- genome
- profile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000056 organs Anatomy 0.000 claims description 19
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 18
- 239000000523 sample Substances 0.000 claims description 18
- 210000001519 tissues Anatomy 0.000 claims description 18
- 239000012472 biological sample Substances 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 210000004027 cells Anatomy 0.000 claims description 14
- 239000012530 fluid Substances 0.000 claims description 12
- 230000000875 corresponding Effects 0.000 claims description 10
- 210000001742 Aqueous Humor Anatomy 0.000 claims description 6
- 210000004369 Blood Anatomy 0.000 claims description 6
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims description 6
- 210000003756 Cervix Mucus Anatomy 0.000 claims description 6
- 210000004080 Milk Anatomy 0.000 claims description 6
- 210000002381 Plasma Anatomy 0.000 claims description 6
- 206010036790 Productive cough Diseases 0.000 claims description 6
- 210000003296 Saliva Anatomy 0.000 claims description 6
- 210000002966 Serum Anatomy 0.000 claims description 6
- 210000003802 Sputum Anatomy 0.000 claims description 6
- 210000001138 Tears Anatomy 0.000 claims description 6
- 210000002700 Urine Anatomy 0.000 claims description 6
- 210000004127 Vitreous Body Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 238000009396 hybridization Methods 0.000 claims description 6
- 230000001926 lymphatic Effects 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000011002 quantification Methods 0.000 claims description 6
- -1 tears Substances 0.000 claims description 6
- 206010061818 Disease progression Diseases 0.000 claims description 4
- 210000000601 Blood Cells Anatomy 0.000 claims description 2
- 210000004204 Blood Vessels Anatomy 0.000 claims description 2
- 210000001185 Bone Marrow Anatomy 0.000 claims description 2
- 210000000988 Bone and Bones Anatomy 0.000 claims description 2
- 210000004556 Brain Anatomy 0.000 claims description 2
- 206010007554 Cardiac failure Diseases 0.000 claims description 2
- 210000000845 Cartilage Anatomy 0.000 claims description 2
- 206010011401 Crohn's disease Diseases 0.000 claims description 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims description 2
- 210000000981 Epithelium Anatomy 0.000 claims description 2
- 210000002744 Extracellular Matrix Anatomy 0.000 claims description 2
- 210000001508 Eye Anatomy 0.000 claims description 2
- 229920002024 GDNA Polymers 0.000 claims description 2
- 210000004907 Glands Anatomy 0.000 claims description 2
- 210000002216 Heart Anatomy 0.000 claims description 2
- 206010019280 Heart failure Diseases 0.000 claims description 2
- 210000000936 Intestines Anatomy 0.000 claims description 2
- 210000003734 Kidney Anatomy 0.000 claims description 2
- 208000001083 Kidney Disease Diseases 0.000 claims description 2
- 210000004185 Liver Anatomy 0.000 claims description 2
- 210000004072 Lung Anatomy 0.000 claims description 2
- 208000004852 Lung Injury Diseases 0.000 claims description 2
- 210000003205 Muscles Anatomy 0.000 claims description 2
- 210000003491 Skin Anatomy 0.000 claims description 2
- 210000002784 Stomach Anatomy 0.000 claims description 2
- 206010070863 Toxicity to various agents Diseases 0.000 claims description 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims description 2
- 210000003932 Urinary Bladder Anatomy 0.000 claims description 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 230000001605 fetal Effects 0.000 claims description 2
- 230000003862 health status Effects 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 210000003292 kidney cell Anatomy 0.000 claims description 2
- 231100000515 lung injury Toxicity 0.000 claims description 2
- 210000002569 neurons Anatomy 0.000 claims description 2
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962796481P | 2019-01-24 | 2019-01-24 | |
| US62/796,481 | 2019-01-24 | ||
| PCT/US2020/014612 WO2020154402A1 (en) | 2019-01-24 | 2020-01-22 | Methods and systems for monitoring organ health and disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024062693A Division JP2024074960A (ja) | 2019-01-24 | 2024-04-09 | 臓器健康および疾患をモニタリングするための方法およびシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022517456A JP2022517456A (ja) | 2022-03-09 |
| JPWO2020154402A5 true JPWO2020154402A5 (ru) | 2023-01-30 |
Family
ID=69726743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020572967A Pending JP2022517456A (ja) | 2019-01-24 | 2020-01-22 | 臓器健康および疾患をモニタリングするための方法およびシステム |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210310067A1 (ru) |
| EP (1) | EP3914731A1 (ru) |
| JP (1) | JP2022517456A (ru) |
| KR (1) | KR20210119282A (ru) |
| CN (1) | CN112424372A (ru) |
| AU (1) | AU2020210912A1 (ru) |
| BR (1) | BR112020026133A2 (ru) |
| CA (1) | CA3104153A1 (ru) |
| IL (1) | IL279433A (ru) |
| MX (1) | MX2020014095A (ru) |
| SG (1) | SG11202012518WA (ru) |
| WO (1) | WO2020154402A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116323978A (zh) * | 2020-10-20 | 2023-06-23 | 深圳华大基因股份有限公司 | 确定孕妇的孕期状态的方法 |
| US20230175064A1 (en) * | 2021-02-09 | 2023-06-08 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| CA3219753A1 (en) * | 2021-05-21 | 2022-11-24 | Kristina KRUGLYAK | Methods and compositions for detecting cancer using fragmentomics |
| CN113403395B (zh) * | 2021-06-03 | 2023-03-24 | 南京世和基因生物技术股份有限公司 | 房水cfDNA的提取方法、试剂盒以及在PVRL临床辅助检查中的应用 |
| WO2023004204A2 (en) * | 2021-07-23 | 2023-01-26 | Georgetown University | Use of circulating cell-free methylated dna to detect tissue damage |
| KR20240051739A (ko) * | 2022-10-13 | 2024-04-22 | 인하대학교 산학협력단 | cfDNA의 구조 변이 서열 검출을 통한 미세잔존질환 진단 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505515XA (en) * | 2012-01-27 | 2015-09-29 | Univ Leland Stanford Junior | Methods for profiling and quantitating cell-free rna |
| JP2016512698A (ja) * | 2013-03-15 | 2016-05-09 | イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド | 尿中セルフリーｄｎａを用いて腎状態を評価するための方法および組成物 |
| EP3165612B1 (en) * | 2014-07-02 | 2021-08-18 | DNA Chip Research Inc. | Method for counting number of nucleic acid molecules |
| WO2016015058A2 (en) * | 2014-07-25 | 2016-01-28 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| US10125399B2 (en) * | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| JP6931236B2 (ja) * | 2015-07-23 | 2021-09-01 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 無細胞ｄｎａの断片化パターンの分析 |
| WO2018000031A1 (en) * | 2016-06-27 | 2018-01-04 | Olivia Newton-John Cancer Research Institute | Use of cell free dna as a measure of organ health following transplantation |
| EP3481966B1 (en) * | 2016-07-06 | 2023-11-08 | Guardant Health, Inc. | Methods for fragmentome profiling of cell-free nucleic acids |
| EP3497242A4 (en) * | 2016-08-10 | 2020-05-13 | Grail, Inc. | METHOD FOR ANALYZING NUCLEIC ACID FRAGMENTS |
| EP3998350A1 (en) * | 2017-03-17 | 2022-05-18 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
| US11781188B2 (en) * | 2017-04-06 | 2023-10-10 | Cornell University | Methods of detecting cell-free DNA in biological samples |
-
2020
- 2020-01-22 BR BR112020026133-5A patent/BR112020026133A2/pt unknown
- 2020-01-22 MX MX2020014095A patent/MX2020014095A/es unknown
- 2020-01-22 JP JP2020572967A patent/JP2022517456A/ja active Pending
- 2020-01-22 CA CA3104153A patent/CA3104153A1/en active Pending
- 2020-01-22 US US17/250,814 patent/US20210310067A1/en active Pending
- 2020-01-22 KR KR1020207037498A patent/KR20210119282A/ko unknown
- 2020-01-22 CN CN202080003539.6A patent/CN112424372A/zh active Pending
- 2020-01-22 AU AU2020210912A patent/AU2020210912A1/en active Pending
- 2020-01-22 SG SG11202012518WA patent/SG11202012518WA/en unknown
- 2020-01-22 WO PCT/US2020/014612 patent/WO2020154402A1/en unknown
- 2020-01-22 EP EP20708291.8A patent/EP3914731A1/en active Pending
- 2020-12-14 IL IL279433A patent/IL279433A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107217089B (zh) | 确定个体状态的方法及装置 | |
| CN107217088B (zh) | 强直性脊柱炎微生物标志物 | |
| CN114182007B (zh) | 白塞病标志基因及其应用 | |
| JPWO2020154402A5 (ru) | ||
| CN104630339B (zh) | 用于急性冠脉综合征早期诊断的循环miRNAs及其应用 | |
| RU2757843C1 (ru) | Способ прогнозирования течения пневмонии у пациентов с подтвержденным covid-19 | |
| CN113999922B (zh) | 急性腹泻标志微生物及其应用 | |
| CN114836508A (zh) | 慢性阻塞性肺病标志微生物及其应用 | |
| RU2020141071A (ru) | Способы и системы мониторинга состояния здоровья и патологии органов | |
| RU2639486C1 (ru) | Способ диагностики кальциноза сосудов сердечно-сосудистой системы | |
| Belhadj et al. | Prevalence of depression in Tunisian general population | |
| Hasiuk et al. | Modern view on mechanisms of epithelium differentiation of the oral mucosa in normal and pathological processes | |
| Jonatan et al. | 61 The Association of Hypertension with Depression, Anxiety and Stress Score in Atma Jaya Hospital | |
| DE502004012230D1 (de) | Verfahren zur diagnose von erkrankungen unter bestimmung von apolipoprotein c-i | |
| Jia et al. | Myotonic dystrophy type 1 presenting with dyspnea: A case report | |
| CN113999923B (zh) | 小柳-原田综合症标志微生物及其应用 | |
| CN114317784B (zh) | 白塞病标志微生物及其应用 | |
| Zielińska‑Krawczyk et al. | Impact of therapeutic thoracentesis and pleural pressure changes on breathing pattern, dyspnea, lung function, and arterial blood gases | |
| Sultana et al. | Electrophysiological changes of motor nerves in patients with type 2 diabetes mellitus | |
| RU2407013C1 (ru) | Способ прогнозирования возникновения рака легкого у больных хронической обструктивной болезнью легких | |
| CN114381507B (zh) | 格雷夫斯病标志微生物及其应用 | |
| Saadi et al. | Anxiety and depression at the medical students in post-examination | |
| CN114317531A (zh) | 小柳-原田综合症标志基因及其应用 | |
| Li et al. | Gut Microbiome Composition Differs between Individuals with Acute and Long-standing traumatic Spinal Cord Injury | |
| Neumann et al. | Help Me Cry Again: A Post-stroke Case Study |