MX2020014095A - Metodos y sistemas para monitorear la salud y enfermedad de organos. - Google Patents

Metodos y sistemas para monitorear la salud y enfermedad de organos.

Info

Publication number
MX2020014095A
MX2020014095A MX2020014095A MX2020014095A MX2020014095A MX 2020014095 A MX2020014095 A MX 2020014095A MX 2020014095 A MX2020014095 A MX 2020014095A MX 2020014095 A MX2020014095 A MX 2020014095A MX 2020014095 A MX2020014095 A MX 2020014095A
Authority
MX
Mexico
Prior art keywords
methods
systems
disease
cfdna
organ health
Prior art date
Application number
MX2020014095A
Other languages
English (en)
Inventor
Yong Li
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of MX2020014095A publication Critical patent/MX2020014095A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se proporcionan métodos, composiciones y sistemas para monitorear la salud de tejidos y órganos. El método, las composiciones y sistemas proporcionados en la presente extraen señales de número de copia específicas de locus de muestras de ADN libre de células (ADNlc) para identificar perfiles de número de copia de ADNlc específicas de tejido y permiten la cuantificación de fracciones de tejido en las muestras de ADNlc.
MX2020014095A 2019-01-24 2020-01-22 Metodos y sistemas para monitorear la salud y enfermedad de organos. MX2020014095A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962796481P 2019-01-24 2019-01-24
PCT/US2020/014612 WO2020154402A1 (en) 2019-01-24 2020-01-22 Methods and systems for monitoring organ health and disease

Publications (1)

Publication Number Publication Date
MX2020014095A true MX2020014095A (es) 2021-03-09

Family

ID=69726743

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020014095A MX2020014095A (es) 2019-01-24 2020-01-22 Metodos y sistemas para monitorear la salud y enfermedad de organos.

Country Status (12)

Country Link
US (1) US20210310067A1 (es)
EP (1) EP3914731A1 (es)
JP (2) JP2022517456A (es)
KR (1) KR20210119282A (es)
CN (1) CN112424372A (es)
AU (1) AU2020210912A1 (es)
BR (1) BR112020026133A2 (es)
CA (1) CA3104153A1 (es)
IL (1) IL279433A (es)
MX (1) MX2020014095A (es)
SG (1) SG11202012518WA (es)
WO (1) WO2020154402A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022082436A1 (zh) * 2020-10-20 2022-04-28 深圳华大基因股份有限公司 确定孕妇的孕期状态的方法
EP4291681A1 (en) * 2021-02-09 2023-12-20 Illumina, Inc. Methods and systems for monitoring organ health and disease
WO2022246232A1 (en) * 2021-05-21 2022-11-24 Petdx, Inc. Methods and compositions for detecting cancer using fragmentomics
CN113403395B (zh) * 2021-06-03 2023-03-24 南京世和基因生物技术股份有限公司 房水cfDNA的提取方法、试剂盒以及在PVRL临床辅助检查中的应用
EP4373972A2 (en) * 2021-07-23 2024-05-29 Georgetown University Use of circulating cell-free methylated dna to detect tissue damage
KR20240051739A (ko) * 2022-10-13 2024-04-22 인하대학교 산학협력단 cfDNA의 구조 변이 서열 검출을 통한 미세잔존질환 진단 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6320302B2 (ja) * 2012-01-27 2018-05-09 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 無細胞ｒｎａをプロファイリングおよび定量するための方法
US20160024581A1 (en) * 2013-03-15 2016-01-28 Immucor Gti Diagnostics, Inc. Methods and compositions for assessing renal status using urine cell free dna
JP6125731B2 (ja) * 2014-07-02 2017-05-10 株式会社Ｄｎａチップ研究所 核酸分子数計測法
WO2016015058A2 (en) * 2014-07-25 2016-01-28 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10125399B2 (en) * 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
HUE064231T2 (hu) * 2015-07-23 2024-02-28 Univ Hong Kong Chinese Sejtmentes DNS fragmentációs mintázatának elemzése
WO2018000031A1 (en) * 2016-06-27 2018-01-04 Olivia Newton-John Cancer Research Institute Use of cell free dna as a measure of organ health following transplantation
EP4322168A3 (en) * 2016-07-06 2024-05-15 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3497242A4 (en) * 2016-08-10 2020-05-13 Grail, Inc. METHOD FOR ANALYZING NUCLEIC ACID FRAGMENTS
EP3596233B1 (en) * 2017-03-17 2022-05-18 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
WO2018187521A2 (en) * 2017-04-06 2018-10-11 Cornell University Methods of detecting cell-free dna in biological samples

Also Published As

Publication number Publication date
AU2020210912A1 (en) 2021-01-21
SG11202012518WA (en) 2021-01-28
IL279433A (en) 2021-01-31
CA3104153A1 (en) 2020-07-30
CN112424372A (zh) 2021-02-26
BR112020026133A2 (pt) 2021-07-27
JP2024074960A (ja) 2024-05-31
KR20210119282A (ko) 2021-10-05
EP3914731A1 (en) 2021-12-01
JP2022517456A (ja) 2022-03-09
WO2020154402A1 (en) 2020-07-30
US20210310067A1 (en) 2021-10-07

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