JPWO2020120801A5 - - Google Patents
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- Publication number
- JPWO2020120801A5 JPWO2020120801A5 JP2021555890A JP2021555890A JPWO2020120801A5 JP WO2020120801 A5 JPWO2020120801 A5 JP WO2020120801A5 JP 2021555890 A JP2021555890 A JP 2021555890A JP 2021555890 A JP2021555890 A JP 2021555890A JP WO2020120801 A5 JPWO2020120801 A5 JP WO2020120801A5
- Authority
- JP
- Japan
- Prior art keywords
- endotoxin
- solid phase
- phase material
- contain
- suspected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002158 endotoxin Substances 0.000 claims description 34
- 239000000463 material Substances 0.000 claims description 20
- 239000007790 solid phase Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 8
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims description 7
- VTLYFUHAOXGGBS-UHFFFAOYSA-N fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 241001515965 unidentified phage Species 0.000 claims description 6
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 4
- 230000027455 binding Effects 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 238000005571 anion exchange chromatography Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 2
- 238000004166 bioassay Methods 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000000975 co-precipitation Methods 0.000 claims description 2
- 238000002270 exclusion chromatography Methods 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000002458 infectious Effects 0.000 claims description 2
- 239000011236 particulate material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 230000001225 therapeutic Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 238000011013 endotoxin removal Methods 0.000 description 4
- MBYLVOKEDDQJDY-UHFFFAOYSA-N Tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DFENKTCEEGOWLB-UHFFFAOYSA-N N,N-bis(methylamino)-2-methylidenepentanamide Chemical compound CCCC(=C)C(=O)N(NC)NC DFENKTCEEGOWLB-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 230000000779 depleting Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000001597 immobilized metal affinity chromatography Methods 0.000 description 1
- 108010053632 lipopolysaccharide-binding protein Proteins 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000813 microbial Effects 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 230000003472 neutralizing Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229960000160 recombinant therapeutic proteins Drugs 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18212639 | 2018-12-14 | ||
| EP18212639.1 | 2018-12-14 | ||
| PCT/EP2019/085401 WO2020120801A1 (en) | 2018-12-14 | 2019-12-16 | A method for depletion or removal of endotoxin from an endotoxin-containing source or potentially endotoxin-containing source |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022528310A JP2022528310A (ja) | 2022-06-10 |
| JPWO2020120801A5 true JPWO2020120801A5 (de) | 2022-12-28 |
Family
ID=65003076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021555890A Pending JP2022528310A (ja) | 2018-12-14 | 2019-12-16 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220056421A1 (de) |
| EP (1) | EP3894579A1 (de) |
| JP (1) | JP2022528310A (de) |
| CN (1) | CN113166792B (de) |
| WO (1) | WO2020120801A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022550777A (ja) | 2019-10-01 | 2022-12-05 | アダプティブ ファージ セラピューティクス， インコーポレイテッド | バクテリオファージ粒子を精製するための方法 |
| EP3995196B1 (de) * | 2020-11-04 | 2023-08-09 | Sartorius BIA Separations d.o.o. | Reinigungsverfahren für lipidmembranumschlossene komplexe zusammenstellungen |
| CN114230641B (zh) * | 2021-12-29 | 2024-03-26 | 内蒙古必威安泰生物科技有限公司 | 一种去除口蹄疫抗原液中内毒素的方法 |
| CN115161308A (zh) * | 2022-06-13 | 2022-10-11 | 江苏丰华生物制药有限公司 | 一种注射用替奈普酶上清液的纯化方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0664814A1 (de) | 1993-08-18 | 1995-08-02 | MorphoSys AG | Lipopolysaccharidbindende und neutralisierende peptide |
| AUPM388494A0 (en) * | 1994-02-16 | 1994-03-10 | Csl Limited | Process for removing endotoxins |
| US20020197249A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products |
| US6365147B1 (en) * | 1999-10-13 | 2002-04-02 | New Jersey Institute Of Technology | Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography |
| CN1137860C (zh) * | 2000-12-20 | 2004-02-11 | 中国科学院生态环境研究中心 | 高铁氧化去除水中微藻素的方法 |
| AU2002258734A1 (en) * | 2001-04-13 | 2002-10-28 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
| GB0211805D0 (en) | 2002-05-22 | 2002-07-03 | Prometic Biosciences Ltd | Endotoxin-binding ligands and their use |
| DE50305695D1 (de) * | 2002-06-24 | 2006-12-28 | Profos Ag | Verfahren zum nachweis und zur entfernung von endotoxin |
| US20060030007A1 (en) * | 2003-05-30 | 2006-02-09 | Byrd Devon R | Peptides for metal ion affinity chromatography |
| US7294614B2 (en) * | 2004-10-12 | 2007-11-13 | Clontech Laboratories, Inc. | Phosphoprotein affinity resins and methods for making and using the same |
| DE102005002969A1 (de) * | 2005-01-21 | 2006-08-03 | Profos Ag | Verfahren zum Nachweis und zur Entfernung von Endotoxin |
| GB0621452D0 (en) * | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Therapy for liver disease |
| US9701558B1 (en) * | 2014-02-08 | 2017-07-11 | Mansour S. Bader | Methods to treat source water for oil-fields heavy oil and other applications |
| SG11201407801VA (en) * | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations |
| CN105121457B (zh) * | 2013-02-22 | 2019-04-30 | 新加坡科技研究局 | 用于从蛋白制剂去除内毒素的材料和方法 |
| JP6320429B2 (ja) * | 2013-02-22 | 2018-05-09 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | 負帯電粒子を用いるウイルス調製物のクロマトグラフィー精製 |
| GB201310151D0 (en) * | 2013-06-07 | 2013-07-24 | Glaxosmithkline Biolog Sa | Novel method |
| WO2017213588A1 (en) * | 2016-06-06 | 2017-12-14 | National University Of Singapore | A method and a kit for detecting and/or quantifying endotoxin |
| CN108743616B (zh) * | 2018-05-30 | 2020-12-25 | 博瑞生物医药（苏州）股份有限公司 | 一种超顺磁氧化铁内毒素的去除方法 |
-
2019
- 2019-12-16 WO PCT/EP2019/085401 patent/WO2020120801A1/en unknown
- 2019-12-16 EP EP19817377.5A patent/EP3894579A1/de active Pending
- 2019-12-16 US US17/312,756 patent/US20220056421A1/en active Pending
- 2019-12-16 CN CN201980082566.4A patent/CN113166792B/zh active Active
- 2019-12-16 JP JP2021555890A patent/JP2022528310A/ja active Pending
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