JPWO2020118213A5 - - Google Patents
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- JPWO2020118213A5 JPWO2020118213A5 JP2021531818A JP2021531818A JPWO2020118213A5 JP WO2020118213 A5 JPWO2020118213 A5 JP WO2020118213A5 JP 2021531818 A JP2021531818 A JP 2021531818A JP 2021531818 A JP2021531818 A JP 2021531818A JP WO2020118213 A5 JPWO2020118213 A5 JP WO2020118213A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cdk4
- resistant
- inhibitor
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 102100038595 Estrogen receptor Human genes 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 10
- 108010007005 Estrogen Receptor alpha Proteins 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 206010006187 Breast cancer Diseases 0.000 claims 4
- -1 DDR2 Proteins 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 239000003886 aromatase inhibitor Substances 0.000 claims 3
- RHXHGRAEPCAFML-UHFFFAOYSA-N 7-cyclopentyl-n,n-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide Chemical compound N1=C2N(C3CCCC3)C(C(=O)N(C)C)=CC2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 RHXHGRAEPCAFML-UHFFFAOYSA-N 0.000 claims 2
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 2
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 2
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 claims 2
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 2
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 2
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 2
- 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 claims 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 2
- 101150097381 Mtor gene Proteins 0.000 claims 2
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 2
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 2
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 2
- 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 claims 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 2
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 2
- 229950001573 abemaciclib Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- UZWDCWONPYILKI-UHFFFAOYSA-N n-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine Chemical compound C1CN(CC)CCN1CC(C=N1)=CC=C1NC1=NC=C(F)C(C=2C=C3N(C(C)C)C(C)=NC3=C(F)C=2)=N1 UZWDCWONPYILKI-UHFFFAOYSA-N 0.000 claims 2
- 229960004390 palbociclib Drugs 0.000 claims 2
- AHJRHEGDXFFMBM-UHFFFAOYSA-N palbociclib Chemical compound N1=C2N(C3CCCC3)C(=O)C(C(=O)C)=C(C)C2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 AHJRHEGDXFFMBM-UHFFFAOYSA-N 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229950003687 ribociclib Drugs 0.000 claims 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 2
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 2
- 102100034580 AT-rich interactive domain-containing protein 1A Human genes 0.000 claims 1
- 102000000872 ATM Human genes 0.000 claims 1
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 claims 1
- 102000004000 Aurora Kinase A Human genes 0.000 claims 1
- 108090000461 Aurora Kinase A Proteins 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 1
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 1
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 102100026008 Breakpoint cluster region protein Human genes 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 claims 1
- 102100028914 Catenin beta-1 Human genes 0.000 claims 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 claims 1
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- 102000009512 Cyclin-Dependent Kinase Inhibitor p15 Human genes 0.000 claims 1
- 108010009356 Cyclin-Dependent Kinase Inhibitor p15 Proteins 0.000 claims 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 1
- 102000000577 Cyclin-Dependent Kinase Inhibitor p27 Human genes 0.000 claims 1
- 108010016777 Cyclin-Dependent Kinase Inhibitor p27 Proteins 0.000 claims 1
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 1
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims 1
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 1
- 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 claims 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 claims 1
- 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 claims 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 1
- 101150097734 EPHB2 gene Proteins 0.000 claims 1
- 102100027100 Echinoderm microtubule-associated protein-like 4 Human genes 0.000 claims 1
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims 1
- 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 claims 1
- 101710105178 F-box/WD repeat-containing protein 7 Proteins 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 102100021066 Fibroblast growth factor receptor substrate 2 Human genes 0.000 claims 1
- 102100040859 Fizzy-related protein homolog Human genes 0.000 claims 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 claims 1
- 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 claims 1
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 claims 1
- 102100029974 GTPase HRas Human genes 0.000 claims 1
- 102100030708 GTPase KRas Human genes 0.000 claims 1
- 102100039788 GTPase NRas Human genes 0.000 claims 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 1
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims 1
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 claims 1
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 1
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 claims 1
- 101001095815 Homo sapiens E3 ubiquitin-protein ligase RING2 Proteins 0.000 claims 1
- 101001057929 Homo sapiens Echinoderm microtubule-associated protein-like 4 Proteins 0.000 claims 1
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 claims 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 claims 1
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 claims 1
- 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 claims 1
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 claims 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 1
- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 1
- 101001050559 Homo sapiens Kinesin-1 heavy chain Proteins 0.000 claims 1
- 101000984620 Homo sapiens Low-density lipoprotein receptor-related protein 1B Proteins 0.000 claims 1
- 101001025967 Homo sapiens Lysine-specific demethylase 6A Proteins 0.000 claims 1
- 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 claims 1
- 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 claims 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 1
- 101000728236 Homo sapiens Polycomb group protein ASXL1 Proteins 0.000 claims 1
- 101000573199 Homo sapiens Protein PML Proteins 0.000 claims 1
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 claims 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 claims 1
- 101100087590 Homo sapiens RICTOR gene Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 101000606537 Homo sapiens Receptor-type tyrosine-protein phosphatase delta Proteins 0.000 claims 1
- 101000742859 Homo sapiens Retinoblastoma-associated protein Proteins 0.000 claims 1
- 101001112293 Homo sapiens Retinoic acid receptor alpha Proteins 0.000 claims 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 claims 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 claims 1
- 101000904150 Homo sapiens Transcription factor E2F3 Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
- 101000740048 Homo sapiens Ubiquitin carboxyl-terminal hydrolase BAP1 Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 1
- 102100023422 Kinesin-1 heavy chain Human genes 0.000 claims 1
- 101000740049 Latilactobacillus curvatus Bioactive peptide 1 Proteins 0.000 claims 1
- 102100027121 Low-density lipoprotein receptor-related protein 1B Human genes 0.000 claims 1
- 102100037462 Lysine-specific demethylase 6A Human genes 0.000 claims 1
- 108010068342 MAP Kinase Kinase 1 Proteins 0.000 claims 1
- 102000017274 MDM4 Human genes 0.000 claims 1
- 108050005300 MDM4 Proteins 0.000 claims 1
- 102100027240 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 1
- 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 claims 1
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 claims 1
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 claims 1
- 102100027096 Nucleotide exchange factor SIL1 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 1
- 102100029799 Polycomb group protein ASXL1 Human genes 0.000 claims 1
- 102100026375 Protein PML Human genes 0.000 claims 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 claims 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 claims 1
- 102000004229 RNA-binding protein EWS Human genes 0.000 claims 1
- 108090000740 RNA-binding protein EWS Proteins 0.000 claims 1
- 108700019586 Rapamycin-Insensitive Companion of mTOR Proteins 0.000 claims 1
- 102000046941 Rapamycin-Insensitive Companion of mTOR Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 102100039666 Receptor-type tyrosine-protein phosphatase delta Human genes 0.000 claims 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 1
- 102100038042 Retinoblastoma-associated protein Human genes 0.000 claims 1
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 1
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims 1
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 claims 1
- 101710145783 TATA-box-binding protein Proteins 0.000 claims 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 claims 1
- 102100024027 Transcription factor E2F3 Human genes 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 229940046836 anti-estrogen Drugs 0.000 claims 1
- 230000001833 anti-estrogenic effect Effects 0.000 claims 1
- 229940046844 aromatase inhibitors Drugs 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862776323P | 2018-12-06 | 2018-12-06 | |
| US62/776,323 | 2018-12-06 | ||
| PCT/US2019/065005 WO2020118213A1 (en) | 2018-12-06 | 2019-12-06 | Methods for treating cancer resistant to cdk4/6 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511498A JP2022511498A (ja) | 2022-01-31 |
| JPWO2020118213A5 true JPWO2020118213A5 (ru) | 2022-12-19 |
| JP7504097B2 JP7504097B2 (ja) | 2024-06-21 |
Family
ID=69063871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531818A Active JP7504097B2 (ja) | 2018-12-06 | 2019-12-06 | Ｃｄｋ４／６阻害剤に耐性の癌を治療するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210330612A1 (ru) |
| EP (1) | EP3890834A1 (ru) |
| JP (1) | JP7504097B2 (ru) |
| KR (1) | KR20210100137A (ru) |
| CN (1) | CN113164779A (ru) |
| AU (1) | AU2019395093A1 (ru) |
| BR (1) | BR112021010110A2 (ru) |
| CA (1) | CA3121930A1 (ru) |
| EA (1) | EA202191283A1 (ru) |
| IL (1) | IL283659A (ru) |
| JO (1) | JOP20210137A1 (ru) |
| MA (1) | MA54388A (ru) |
| MX (1) | MX2021006411A (ru) |
| SG (1) | SG11202105531XA (ru) |
| WO (1) | WO2020118213A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3202592A1 (en) * | 2020-12-14 | 2022-06-23 | Arvinas Operations, Inc. | Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders |
| GB202116745D0 (en) * | 2021-11-19 | 2022-01-05 | Institute Of Cancer Res Royal Cancer Hospital | Prognostic and treatment response predictive method |
| CN115369089A (zh) * | 2022-08-11 | 2022-11-22 | 中山大学孙逸仙纪念医院 | 两种er阳性her-2阴性乳腺癌cdk4/6抑制剂耐药株及其构建方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421264B2 (en) * | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| AU2016256470B2 (en) * | 2015-04-29 | 2020-10-15 | Radius Pharmaceuticals, Inc. | Methods of treating cancer |
| LT3565542T (lt) * | 2017-01-05 | 2024-07-10 | Radius Pharmaceuticals, Inc. | Polimorfinės rad1901-2hcl formos |
| CN112423844B (zh) * | 2018-07-04 | 2024-08-13 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
-
2019
- 2019-12-06 JP JP2021531818A patent/JP7504097B2/ja active Active
- 2019-12-06 US US17/299,948 patent/US20210330612A1/en active Pending
- 2019-12-06 MA MA054388A patent/MA54388A/fr unknown
- 2019-12-06 JO JOP/2021/0137A patent/JOP20210137A1/ar unknown
- 2019-12-06 MX MX2021006411A patent/MX2021006411A/es unknown
- 2019-12-06 SG SG11202105531XA patent/SG11202105531XA/en unknown
- 2019-12-06 EA EA202191283A patent/EA202191283A1/ru unknown
- 2019-12-06 BR BR112021010110-1A patent/BR112021010110A2/pt unknown
- 2019-12-06 KR KR1020217020435A patent/KR20210100137A/ko active Search and Examination
- 2019-12-06 CN CN201980081052.7A patent/CN113164779A/zh active Pending
- 2019-12-06 AU AU2019395093A patent/AU2019395093A1/en active Pending
- 2019-12-06 EP EP19829727.7A patent/EP3890834A1/en active Pending
- 2019-12-06 WO PCT/US2019/065005 patent/WO2020118213A1/en active Application Filing
- 2019-12-06 CA CA3121930A patent/CA3121930A1/en active Pending
-
2021
- 2021-06-02 IL IL283659A patent/IL283659A/en unknown
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