JPWO2020084115A5 - - Google Patents
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- Publication number
- JPWO2020084115A5 JPWO2020084115A5 JP2021523064A JP2021523064A JPWO2020084115A5 JP WO2020084115 A5 JPWO2020084115 A5 JP WO2020084115A5 JP 2021523064 A JP2021523064 A JP 2021523064A JP 2021523064 A JP2021523064 A JP 2021523064A JP WO2020084115 A5 JPWO2020084115 A5 JP WO2020084115A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkylene
- substituted
- substituents
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382759.1 | 2018-10-25 | ||
| EP18382759 | 2018-10-25 | ||
| PCT/EP2019/079188 WO2020084115A1 (en) | 2018-10-25 | 2019-10-25 | Antibody drug conjugates comprising ecteinascidin derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022512830A JP2022512830A (ja) | 2022-02-07 |
| JPWO2020084115A5 true JPWO2020084115A5 (https=) | 2024-03-21 |
| JP2022512830A5 JP2022512830A5 (https=) | 2024-03-21 |
| JP7629400B2 JP7629400B2 (ja) | 2025-02-13 |
Family
ID=64426824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523064A Active JP7629400B2 (ja) | 2018-10-25 | 2019-10-25 | エクテナサイジン誘導体を含む薬物抗体複合体 |
Country Status (37)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20231233T1 (hr) * | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| TW202144369A (zh) * | 2020-04-26 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 海鞘素類衍生物及其製備方法與醫藥用途 |
| US11124568B1 (en) * | 2020-08-19 | 2021-09-21 | Vitruviae LLC | CD3/CD25 antibodies for neuro-immune diseases |
| TW202313039A (zh) * | 2021-05-19 | 2023-04-01 | 西班牙商瑪製藥股份有限公司 | Pm14用途與方案 |
| KR102625740B1 (ko) * | 2021-07-15 | 2024-01-17 | 주식회사 새한비엠 | 폐수지 재료 및 미네랄 바인더를 이용한 단열차음재의 제조 방법 및 그 단열차음재 |
| CN120417935A (zh) * | 2022-10-25 | 2025-08-01 | 默沙东有限责任公司 | 依喜替康衍生的adc接头-载荷及其药物组合物和用途 |
| WO2024155565A2 (en) * | 2023-01-17 | 2024-07-25 | Yarrow Therapeutics, Inc. | Ecteinascidin derivative antibody drug conjugates |
| WO2024186263A1 (en) | 2023-03-07 | 2024-09-12 | Axcynsis Therapeutics Pte. Ltd. | Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives |
| CN118878690B (zh) * | 2023-11-28 | 2026-01-09 | 南京大学 | 一种抗地高辛纳米抗体的制备及其应用 |
| WO2025228595A1 (en) * | 2024-04-30 | 2025-11-06 | Pharma Mar, S.A. | Use of compound ia in the treatment of cancers including combination therapy with atezolizumab. |
| TW202547488A (zh) * | 2024-04-30 | 2025-12-16 | 西班牙商瑪製藥股份有限公司 | 於癌症的治療中之化合物Ｉａ和拓樸異構酶Ｉ抑制劑的組合 |
| WO2025233522A1 (en) * | 2024-05-10 | 2025-11-13 | Pharma Mar, S.A. | Synthetic process for an ecteinascidin |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| AR054181A1 (es) * | 2004-08-26 | 2007-06-06 | Nicholas Piramal India Ltd | Prodrogas que contienen enlaces bio-divisibles. composiiciones farmaceuticas |
| EP1817059A2 (en) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Conjugates of 1,8-bis-naphthalimides with an antibody |
| EP3539572A1 (en) | 2005-08-24 | 2019-09-18 | ImmunoGen, Inc. | Process for preparing maytansinoid antibody conjugates |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| GB201506405D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| HRP20231233T1 (hr) * | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| KR20230004714A (ko) * | 2020-04-21 | 2023-01-06 | 파르마 마르, 에스.에이. | 약물 항체 접합체 |
-
2019
- 2019-10-23 TW TW108138205A patent/TWI824043B/zh active
- 2019-10-24 AR ARP190103069A patent/AR117657A1/es unknown
- 2019-10-25 MD MDE20210819T patent/MD3870234T2/ro unknown
- 2019-10-25 WO PCT/EP2019/079188 patent/WO2020084115A1/en not_active Ceased
- 2019-10-25 UA UAA202102699A patent/UA129803C2/uk unknown
- 2019-10-25 MY MYPI2021002234A patent/MY206221A/en unknown
- 2019-10-25 MA MA59661A patent/MA59661B1/fr unknown
- 2019-10-25 CA CA3117268A patent/CA3117268C/en active Active
- 2019-10-25 US US17/288,567 patent/US20230012681A1/en active Pending
- 2019-10-25 BR BR112021007718-9A patent/BR112021007718A2/pt unknown
- 2019-10-25 RS RS20230219A patent/RS64068B1/sr unknown
- 2019-10-25 FI FIEP19790550.8T patent/FI3870234T3/fi active
- 2019-10-25 KR KR1020217015900A patent/KR20210086669A/ko active Pending
- 2019-10-25 EP EP19790550.8A patent/EP3870234B1/en active Active
- 2019-10-25 SM SM20230076T patent/SMT202300076T1/it unknown
- 2019-10-25 CN CN201980084790.7A patent/CN113226377B/zh active Active
- 2019-10-25 AU AU2019368687A patent/AU2019368687B2/en active Active
- 2019-10-25 IL IL282577A patent/IL282577B2/en unknown
- 2019-10-25 SI SI201930466T patent/SI3870234T1/sl unknown
- 2019-10-25 HU HUE19790550A patent/HUE061606T2/hu unknown
- 2019-10-25 MX MX2021004746A patent/MX2021004746A/es unknown
- 2019-10-25 PT PT197905508T patent/PT3870234T/pt unknown
- 2019-10-25 HR HRP20230275TT patent/HRP20230275T1/hr unknown
- 2019-10-25 DK DK19790550.8T patent/DK3870234T3/da active
- 2019-10-25 LT LTEPPCT/EP2019/079188T patent/LT3870234T/lt unknown
- 2019-10-25 SG SG11202104154WA patent/SG11202104154WA/en unknown
- 2019-10-25 ES ES19790550T patent/ES2939494T3/es active Active
- 2019-10-25 EA EA202191131A patent/EA202191131A1/ru unknown
- 2019-10-25 JP JP2021523064A patent/JP7629400B2/ja active Active
- 2019-10-25 PL PL19790550.8T patent/PL3870234T3/pl unknown
-
2021
- 2021-04-22 CL CL2021001039A patent/CL2021001039A1/es unknown
- 2021-04-23 PH PH12021550930A patent/PH12021550930A1/en unknown
- 2021-04-25 JO JOJO/P/2021/0083A patent/JOP20210083B1/ar active
- 2021-04-25 SA SA521421855A patent/SA521421855B1/ar unknown
- 2021-05-20 EC ECSENADI202135414A patent/ECSP21035414A/es unknown
- 2021-05-21 ZA ZA2021/03478A patent/ZA202103478B/en unknown
- 2021-05-24 CO CONC2021/0006838A patent/CO2021006838A2/es unknown
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