JPWO2020074459A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020074459A5 JPWO2020074459A5 JP2021518891A JP2021518891A JPWO2020074459A5 JP WO2020074459 A5 JPWO2020074459 A5 JP WO2020074459A5 JP 2021518891 A JP2021518891 A JP 2021518891A JP 2021518891 A JP2021518891 A JP 2021518891A JP WO2020074459 A5 JPWO2020074459 A5 JP WO2020074459A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody fragment
- human
- domain
- met antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 34
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 34
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 235000001014 amino acid Nutrition 0.000 claims 12
- 239000000047 product Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- 101000746783 Homo sapiens Cytochrome b-c1 complex subunit 6, mitochondrial Proteins 0.000 claims 5
- 102000048638 human UQCRH Human genes 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 101150105382 MET gene Proteins 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 101000654674 Homo sapiens Semaphorin-6A Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 102100032795 Semaphorin-6A Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000012761 co-transfection Methods 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000009282A IT201800009282A1 (it) | 2018-10-09 | 2018-10-09 | Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi |
| IT102018000009282 | 2018-10-09 | ||
| PCT/EP2019/077116 WO2020074459A1 (en) | 2018-10-09 | 2019-10-07 | Anti-met fab-fc for the treatment of a tumor and/or metastasis |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022504392A JP2022504392A (ja) | 2022-01-13 |
| JPWO2020074459A5 true JPWO2020074459A5 (https=) | 2022-05-12 |
| JP2022504392A5 JP2022504392A5 (https=) | 2022-05-12 |
| JP7371093B2 JP7371093B2 (ja) | 2023-10-30 |
Family
ID=65010823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518891A Active JP7371093B2 (ja) | 2018-10-09 | 2019-10-07 | 腫瘍および／または転移の治療のための抗－ｍｅｔ ｆａｂ－ｆｃ |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12209129B2 (https=) |
| EP (2) | EP3864050B1 (https=) |
| JP (1) | JP7371093B2 (https=) |
| KR (2) | KR20250078600A (https=) |
| CN (2) | CN119587692A (https=) |
| AU (2) | AU2019358417B2 (https=) |
| CA (1) | CA3115582A1 (https=) |
| CY (1) | CY1125831T1 (https=) |
| DK (1) | DK3864050T5 (https=) |
| ES (1) | ES2938714T3 (https=) |
| FI (1) | FI3864050T3 (https=) |
| HR (1) | HRP20230154T1 (https=) |
| HU (1) | HUE060843T2 (https=) |
| IL (1) | IL282033B2 (https=) |
| IT (1) | IT201800009282A1 (https=) |
| LT (1) | LT3864050T (https=) |
| PL (1) | PL3864050T3 (https=) |
| PT (1) | PT3864050T (https=) |
| RS (1) | RS63960B1 (https=) |
| SG (1) | SG11202103575RA (https=) |
| SI (1) | SI3864050T1 (https=) |
| SM (1) | SMT202300053T1 (https=) |
| WO (1) | WO2020074459A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20260019463A (ko) | 2023-06-01 | 2026-02-10 | 피에르 파브르 메디카먼트 | 종양 및 전이의 치료를 위한 침묵화된 항체 기반의 항-met 구조물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100956913B1 (ko) * | 2003-12-19 | 2010-05-11 | 제넨테크, 인크. | 치료제로서 유용한 일가 항체 단편 |
| CA2638889C (en) | 2006-02-06 | 2015-06-02 | Metheresis Translational Research S.A. | Anti-met monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products |
| ES2547248T3 (es) * | 2006-04-28 | 2015-10-02 | Delenex Therapeutics Ag | Anticuerpos que se unen al dominio extracelular del receptor Tirosina cinasa ALK |
| NZ591087A (en) * | 2008-10-01 | 2012-08-31 | Micromet Ag | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| EP2376109B1 (en) * | 2008-12-19 | 2019-01-23 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| MX2011010265A (es) * | 2009-04-01 | 2011-10-11 | Genentech Inc | Anticuerpos anti-fcrh5 e inmunoconjugados y metodos de uso. |
| DK2500036T3 (da) * | 2011-03-18 | 2014-08-04 | Metheresis Translational Res Sa | MET-hæmmere til øgning af virkningen af radioterapi |
| KR20140033029A (ko) * | 2011-04-01 | 2014-03-17 | 메모리얼 슬로안-케터링 캔서 센터 | 에이치엘에이 에이2에 의해 제공된 더블유티1 펩타이드에 특이적인 티 세포 수용체 유사 항체 |
| EP2748197A2 (en) * | 2011-08-26 | 2014-07-02 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| EP2782932A1 (en) * | 2011-11-21 | 2014-10-01 | F.Hoffmann-La Roche Ag | Purification of anti-c-met antibodies |
| ITTO20130012A1 (it) * | 2013-01-09 | 2014-07-10 | Metheresis Translational Res S A | Nuovi frammenti anticorpali, relative composizioni ed usi |
| GB201403875D0 (en) * | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| MX2019008538A (es) * | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
-
2018
- 2018-10-09 IT IT102018000009282A patent/IT201800009282A1/it unknown
-
2019
- 2019-10-07 PL PL19808675.3T patent/PL3864050T3/pl unknown
- 2019-10-07 US US17/283,482 patent/US12209129B2/en active Active
- 2019-10-07 HU HUE19808675A patent/HUE060843T2/hu unknown
- 2019-10-07 LT LTEPPCT/EP2019/077116T patent/LT3864050T/lt unknown
- 2019-10-07 SI SI201930456T patent/SI3864050T1/sl unknown
- 2019-10-07 CN CN202411779087.7A patent/CN119587692A/zh active Pending
- 2019-10-07 KR KR1020257016475A patent/KR20250078600A/ko active Pending
- 2019-10-07 KR KR1020217013513A patent/KR102814490B1/ko active Active
- 2019-10-07 HR HRP20230154TT patent/HRP20230154T1/hr unknown
- 2019-10-07 CA CA3115582A patent/CA3115582A1/en active Pending
- 2019-10-07 ES ES19808675T patent/ES2938714T3/es active Active
- 2019-10-07 WO PCT/EP2019/077116 patent/WO2020074459A1/en not_active Ceased
- 2019-10-07 AU AU2019358417A patent/AU2019358417B2/en active Active
- 2019-10-07 FI FIEP19808675.3T patent/FI3864050T3/fi active
- 2019-10-07 EP EP19808675.3A patent/EP3864050B1/en active Active
- 2019-10-07 SG SG11202103575RA patent/SG11202103575RA/en unknown
- 2019-10-07 CN CN201980080611.2A patent/CN113330032B/zh active Active
- 2019-10-07 EP EP22206743.1A patent/EP4194469A1/en active Pending
- 2019-10-07 RS RS20230107A patent/RS63960B1/sr unknown
- 2019-10-07 IL IL282033A patent/IL282033B2/en unknown
- 2019-10-07 DK DK19808675.3T patent/DK3864050T5/da active
- 2019-10-07 JP JP2021518891A patent/JP7371093B2/ja active Active
- 2019-10-07 SM SM20230053T patent/SMT202300053T1/it unknown
- 2019-10-07 PT PT198086753T patent/PT3864050T/pt unknown
-
2023
- 2023-02-09 CY CY20231100073T patent/CY1125831T1/el unknown
-
2024
- 2024-12-09 US US18/973,463 patent/US20250101115A1/en active Pending
-
2026
- 2026-02-26 AU AU2026201438A patent/AU2026201438A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2025238141A1 (en) | Hetero-dimeric multi-specific antibody format | |
| CN103649123A (zh) | 抗g-csfr抗体及其用途 | |
| CN115361972A (zh) | 工程化抗her2双特异性蛋白 | |
| CN116284396B (zh) | NKp46抗体及其用途 | |
| WO2023208182A1 (zh) | 抗ccr8抗体及其用途 | |
| CN117120478A (zh) | 一种抗原结合分子 | |
| WO2024046301A1 (zh) | 包含taci多肽的融合蛋白及其用途 | |
| WO2023174238A9 (zh) | 特异性结合gprc5d和cd3的抗原结合分子及其医药用途 | |
| US8207307B2 (en) | Antibodies against human CCN1 and uses thereof | |
| JP2022504392A5 (https=) | ||
| JPWO2020074459A5 (https=) | ||
| FI3864050T3 (fi) | Anti-met-fab-fc kasvaimen ja/tai metastaasin hoitamiseksi | |
| US20260109781A1 (en) | Anti-her2 antibodies and methods of use thereof | |
| JP2024534824A (ja) | 操作された抗ｈｅｒ２二重特異性タンパク質 | |
| HK40084724A (en) | Engineered anti-her2 bispecific proteins | |
| JPWO2022150521A5 (https=) | ||
| HK40110414A (zh) | 抗her2抗体及其使用方法 | |
| WO2025131024A1 (zh) | 一种包含特异性结合dll3和cd3的双特异性抗体的药物组合物 | |
| CN117916259A (zh) | 特异性结合cgrp和pacap的抗原结合分子及其医药用途 |