JPWO2020073131A5 - - Google Patents
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- Publication number
- JPWO2020073131A5 JPWO2020073131A5 JP2021520222A JP2021520222A JPWO2020073131A5 JP WO2020073131 A5 JPWO2020073131 A5 JP WO2020073131A5 JP 2021520222 A JP2021520222 A JP 2021520222A JP 2021520222 A JP2021520222 A JP 2021520222A JP WO2020073131 A5 JPWO2020073131 A5 JP WO2020073131A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- chain variable
- variable domain
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 57
- 108091007433 antigens Proteins 0.000 claims 57
- 102000036639 antigens Human genes 0.000 claims 57
- 229920001184 polypeptide Polymers 0.000 claims 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 102100035139 Folate receptor alpha Human genes 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 102000010451 Folate receptor alpha Human genes 0.000 claims 1
- 108050001931 Folate receptor alpha Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862744059P | 2018-10-10 | 2018-10-10 | |
| US62/744,059 | 2018-10-10 | ||
| PCT/CA2019/051448 WO2020073131A1 (en) | 2018-10-10 | 2019-10-10 | Antibody constructs binding 4-1bb and tumor-associated antigens and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022504826A JP2022504826A (ja) | 2022-01-13 |
| JP2022504826A5 JP2022504826A5 (https=) | 2022-10-18 |
| JPWO2020073131A5 true JPWO2020073131A5 (https=) | 2022-10-18 |
| JP7596263B2 JP7596263B2 (ja) | 2024-12-09 |
Family
ID=70164178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021520222A Active JP7596263B2 (ja) | 2018-10-10 | 2019-10-10 | ４－１ｂｂ及び腫瘍関連抗原に結合する抗体構築物ならびにその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230052369A1 (https=) |
| EP (1) | EP3864051A4 (https=) |
| JP (1) | JP7596263B2 (https=) |
| KR (1) | KR20210076918A (https=) |
| CN (2) | CN112996809A (https=) |
| AU (1) | AU2019356806B2 (https=) |
| BR (1) | BR112021006784A2 (https=) |
| CA (1) | CA3113539A1 (https=) |
| MX (1) | MX2021004058A (https=) |
| WO (1) | WO2020073131A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021207827A1 (en) * | 2020-04-15 | 2021-10-21 | Zymeworks Inc. | Antibody constructs binding 4-1bb and folate receptor alpha and uses thereof |
| MX2022013944A (es) * | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CA3216342A1 (en) * | 2021-04-23 | 2022-10-27 | Hassan ISSAFRAS | Anti-gpc3 antibodies, multispecific antibodies and methods of use |
| CN116769041A (zh) * | 2022-03-10 | 2023-09-19 | 合肥瀚科迈博生物技术有限公司 | 靶向msln和4-1bb的双特异性抗体及其应用 |
| EP4584300A1 (en) * | 2022-09-06 | 2025-07-16 | TJ Biopharma (Shanghai) Co., Ltd. | Multispecific constructs and uses thereof |
| US20240190958A1 (en) * | 2022-10-18 | 2024-06-13 | Tubulis Gmbh | Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof |
| WO2025131027A1 (en) * | 2023-12-21 | 2025-06-26 | Lanova Medicines Development Co., Ltd. | Anti-slc34a2/anti-4-1bb antibodies and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9402865B2 (en) * | 2011-01-18 | 2016-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| EP3593812A3 (en) * | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| AU2017252233A1 (en) * | 2016-04-22 | 2018-11-15 | Alligator Bioscience Ab | Novel bispecific polypeptides against CD137 |
| KR20240000650A (ko) * | 2016-10-19 | 2024-01-02 | 인벤라 인코포레이티드 | 항체 구조물 |
| IL268836B2 (en) * | 2017-02-24 | 2024-04-01 | Macrogenics Inc | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
-
2019
- 2019-10-10 CN CN201980066726.6A patent/CN112996809A/zh active Pending
- 2019-10-10 EP EP19871359.6A patent/EP3864051A4/en active Pending
- 2019-10-10 AU AU2019356806A patent/AU2019356806B2/en active Active
- 2019-10-10 CN CN202511697951.3A patent/CN121758617A/zh active Pending
- 2019-10-10 KR KR1020217011608A patent/KR20210076918A/ko active Pending
- 2019-10-10 JP JP2021520222A patent/JP7596263B2/ja active Active
- 2019-10-10 MX MX2021004058A patent/MX2021004058A/es unknown
- 2019-10-10 WO PCT/CA2019/051448 patent/WO2020073131A1/en not_active Ceased
- 2019-10-10 BR BR112021006784-1A patent/BR112021006784A2/pt unknown
- 2019-10-10 CA CA3113539A patent/CA3113539A1/en active Pending
-
2021
- 2021-04-09 US US17/226,834 patent/US20230052369A1/en active Pending
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