JPWO2020061474A5 - - Google Patents
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- Publication number
- JPWO2020061474A5 JPWO2020061474A5 JP2021515532A JP2021515532A JPWO2020061474A5 JP WO2020061474 A5 JPWO2020061474 A5 JP WO2020061474A5 JP 2021515532 A JP2021515532 A JP 2021515532A JP 2021515532 A JP2021515532 A JP 2021515532A JP WO2020061474 A5 JPWO2020061474 A5 JP WO2020061474A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- skin
- compound
- surfactant
- iron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 14
- 238000009472 formulation Methods 0.000 claims 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052742 iron Inorganic materials 0.000 claims 5
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 4
- 210000003491 Skin Anatomy 0.000 claims 4
- 239000002738 chelating agent Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- -1 Polyoxyethylene Polymers 0.000 claims 2
- 229940068968 Polysorbate 80 Drugs 0.000 claims 2
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 2
- LWZFANDGMFTDAV-URHIDPGUSA-N [(2R)-2-[(3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-URHIDPGUSA-N 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 239000010408 film Substances 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 2
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims 2
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 claims 1
- 206010008570 Chloasma Diseases 0.000 claims 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M Dioctyl sodium sulfosuccinate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims 1
- 229960000878 Docusate Sodium Drugs 0.000 claims 1
- 206010022114 Injury Diseases 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 210000004761 Scalp Anatomy 0.000 claims 1
- 206010039580 Scar Diseases 0.000 claims 1
- 206010040829 Skin discolouration Diseases 0.000 claims 1
- 206010064127 Solar lentigo Diseases 0.000 claims 1
- 239000004147 Sorbitan trioleate Substances 0.000 claims 1
- 229960000391 Sorbitan trioleate Drugs 0.000 claims 1
- 206010062696 Spider vein Diseases 0.000 claims 1
- FPKOPBFLPLFWAD-UHFFFAOYSA-N Trinitrotoluene Chemical compound CC1=CC=C([N+]([O-])=O)C([N+]([O-])=O)=C1[N+]([O-])=O FPKOPBFLPLFWAD-UHFFFAOYSA-N 0.000 claims 1
- PRXRUNOAOLTIEF-XDTJCZEISA-N [2-[(2R,3S,4R)-4-hydroxy-3-[(Z)-octadec-9-enoyl]oxyoxolan-2-yl]-2-[(Z)-octadec-9-enoyl]oxyethyl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@@H](O)[C@@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-XDTJCZEISA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 201000004384 alopecia Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 230000001815 facial Effects 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 230000003803 hair density Effects 0.000 claims 1
- 239000000797 iron chelating agent Substances 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 230000037370 skin discoloration Effects 0.000 claims 1
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Claims (10)
- 低下した毛髪密度、痩せた皮膚、皺、皮膚上の細線、乾燥した、鱗状の、若しくは痒みを伴う皮膚、脱毛症、老化、皮膚変色、日焼け染み、加齢染み、目元の隈、外傷若しくは手術後の打撲傷、肝斑、傷痕、又はくも状静脈の経皮的な審美的皮膚治療の為に処方されたクリーム、ローション、若しくはフィルム組成物中に鉄キレーター化合物若しくはその薬剤的に許容可能な塩を含む、製剤。
- 前記鉄キレーター化合物は前記クリーム、ローション、若しくはフィルム組成物中で安定化される、請求項１に記載の製剤。
- 前記鉄キレーター化合物は逆ミセル構造中に封入される、請求項１に記載の製剤。
- 前記鉄キレーター化合物若しくはその薬剤的に許容可能な塩は、前記逆ミセル内に少なくとも１つの界面活性剤を用いて封入される、請求項３に記載の製剤。
- 前記少なくとも１つの界面活性剤は、トウィーン（TWEEN）８５（登録商標）（ポリオキシエチレン（２０）ソルビタントリオレエート（Polyoxyethylene (20) Sorbitan Trioleate））、リン脂質類、脂肪酸エステル類、トリトン（TRITON）Ｘ－１００（登録商標）（オクチルフェノールエチレンオキシド凝縮物（Octylphenol ethylene oxide condensate））、ＡＯＴ（ジオクチルスルホスクシネート）－トウィーン（TWEEN）８０（登録商標）（ポリソルベート（Polysorbate）８０）、スパン（Span）２０（ソルビタンモノラウレート）、ＡＯＴ－ＤＯＬＰＡ（ジオレイルリン酸）、ＡＯＴ－ＯＰＥ４（ｐ，ｔ－オクチルフェノキシエトキシエタノール）、ＣＴＡＢ（セチルトリメチルアンモニウムブロミド）－ＴＲＰＯ（混合トリアルキルホスフィンオキシド類）、脂肪アルコール類、及びＣＴＡＢ（セチルトリメチルアンモニウムブロミド）のうちの１つ以上を含む、請求項４に記載の製剤。
- 前記少なくとも１つの界面活性剤は、ポリソルベート（Polysorbate）８０及びソルビタンモノラウレート（スパン（Span）２０）の少なくとも１つを含む、請求項５に記載の製剤。
- 前記少なくとも１つの界面活性剤は１％ｗ／ｗ～２５％ｗ／ｗの濃度で存在する、請求項５に記載の製剤。
- 前記鉄キレート化合物は、前記製剤内に１％～３５％ｗ／ｗの濃度で存在する、請求項１～７のいずれか１項に記載の製剤。
- 前記鉄キレート化合物は、前記製剤内に１５％ｗ／ｗの濃度で存在する、請求項８に記載の製剤。
- 前記製剤は被験者の顔の皮膚若しくは頭皮と適合可能となるように構成される、請求項１に記載の製剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862734164P | 2018-09-20 | 2018-09-20 | |
| US62/734,164 | 2018-09-20 | ||
| PCT/US2019/052192 WO2020061474A1 (en) | 2018-09-20 | 2019-09-20 | Iron chelating compounds for treating aesthetic skin conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022501372A JP2022501372A (ja) | 2022-01-06 |
| JPWO2020061474A5 true JPWO2020061474A5 (ja) | 2022-09-15 |
Family
ID=69887931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021515532A Pending JP2022501372A (ja) | 2018-09-20 | 2019-09-20 | 審美的皮膚状態を治療する為の鉄キレート化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210315789A1 (ja) |
| EP (1) | EP3852711A4 (ja) |
| JP (1) | JP2022501372A (ja) |
| KR (1) | KR20210065968A (ja) |
| CN (1) | CN113038920A (ja) |
| AU (1) | AU2019342136A1 (ja) |
| BR (1) | BR112021004905A2 (ja) |
| CA (1) | CA3113175A1 (ja) |
| CL (1) | CL2021000660A1 (ja) |
| IL (1) | IL281405A (ja) |
| SG (1) | SG11202102345SA (ja) |
| WO (1) | WO2020061474A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11969417B2 (en) | 2019-01-28 | 2024-04-30 | Tomorrowlabs Gmbh | Topical formulation for use in alopecia |
| WO2023034701A1 (en) * | 2021-08-30 | 2023-03-09 | Tautona Group Ip Holding Company, L.L.C. | Hif-1 promoting compounds for treating autonomic skin dysfunction following spinal cord injury |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7302M (ja) * | 1966-03-04 | 1969-09-29 | ||
| EP0496434B1 (en) * | 1987-10-22 | 1999-02-03 | The Procter & Gamble Company | Photoprotection compositions comprising chelating agents |
| JPH10182407A (ja) * | 1996-12-24 | 1998-07-07 | Kose Corp | 皮膚外用剤 |
| JP2000136122A (ja) * | 1998-10-28 | 2000-05-16 | Kose Corp | 皮膚外用剤 |
| FR2825920B1 (fr) * | 2001-06-15 | 2006-04-28 | Oreal | Desferal comme inhibiteur de no-synthase et utilisations |
| EP1565185A4 (en) * | 2002-11-07 | 2011-01-05 | Technion Res & Dev Foundation | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH |
| ITMI20022447A1 (it) * | 2002-11-19 | 2004-05-20 | Carlo Ghisalberti | Uso di piridinoni nel trattamento della purpura capillare ed affezioni cutanee correlate. |
| KR101045658B1 (ko) * | 2003-11-17 | 2011-07-01 | 쎄데르마 | 테트라펩티드 및 트리펩티드 혼합물을 포함하는 조성물 |
| FR2869229B1 (fr) * | 2004-04-26 | 2006-08-25 | Sederma Soc Par Actions Simpli | Utilisation d'un inducteur des ugt par voie topique |
| WO2005115379A2 (en) * | 2004-05-24 | 2005-12-08 | New York University | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
| US7763289B2 (en) * | 2005-09-01 | 2010-07-27 | JoAl's Products, LLC | Topical turmeric skin care products |
| ITMI20052262A1 (it) * | 2005-11-25 | 2007-05-26 | Fitologica Srl | Composizioni farmaceutiche e-o dermatocosmetiche topiche per il trattamento della alopecia androgenetica |
| FR2900573B1 (fr) * | 2006-05-05 | 2014-05-16 | Sederma Sa | Nouvelles compositions cosmetiques renfermant au moins un peptide contenant au moins un cycle aromatique bloque |
| US20100092546A1 (en) * | 2008-10-10 | 2010-04-15 | Gurtner Geoffrey C | Topical and Transdermal Delivery of HIF-1 Modulators to Prevent and Treat Chronic Wounds |
| US20140370078A1 (en) * | 2013-06-12 | 2014-12-18 | The Board Of Trustees Of The Leland Stanford Junior University | Topical and Transdermal Delivery of HIF-1 Modulators to Prevent and Treat Chronic Wounds |
| US10098857B2 (en) * | 2008-10-10 | 2018-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds |
| US20120207688A1 (en) * | 2009-10-28 | 2012-08-16 | Guthery B Eugene | Rosacea Topical Skin Treatment Method and Formulation |
| US20100172865A1 (en) * | 2010-03-18 | 2010-07-08 | Shantha Totada R | Methods of enhancing hair growth |
| GB2481712B (en) * | 2010-06-30 | 2013-01-30 | Pangaea Lab Ltd | Composition comprising vascular endothelial growth factor (VEGF) for the treatment of hair loss |
| CN104768522A (zh) * | 2012-07-12 | 2015-07-08 | 帝斯曼知识产权资产管理有限公司 | 包含苄基磺酰基-d-丝氨酸-高苯丙氨酸-(4-脒基-苄基酰胺)和多元醇的美容组合物 |
| EA037605B1 (ru) * | 2014-02-18 | 2021-04-20 | Медзис Фарма | Применение обратно-мицеллярных систем для доставки реагентов, хелатирующих радионуклиды и металлы |
| US20160199437A1 (en) * | 2015-01-08 | 2016-07-14 | D. Travis Wilson | Therapeutic compositions including iron chelators and uses thereof |
| EP3310354A4 (en) * | 2015-06-17 | 2018-12-12 | Dispersol Technologies, LLC | Improved formulations of deferasirox and methods of making the same |
-
2019
- 2019-09-20 US US17/273,855 patent/US20210315789A1/en not_active Abandoned
- 2019-09-20 CN CN201980074073.6A patent/CN113038920A/zh active Pending
- 2019-09-20 JP JP2021515532A patent/JP2022501372A/ja active Pending
- 2019-09-20 AU AU2019342136A patent/AU2019342136A1/en not_active Abandoned
- 2019-09-20 KR KR1020217011391A patent/KR20210065968A/ko active Search and Examination
- 2019-09-20 BR BR112021004905-3A patent/BR112021004905A2/pt not_active Application Discontinuation
- 2019-09-20 EP EP19862327.4A patent/EP3852711A4/en not_active Withdrawn
- 2019-09-20 SG SG11202102345SA patent/SG11202102345SA/en unknown
- 2019-09-20 CA CA3113175A patent/CA3113175A1/en active Pending
- 2019-09-20 WO PCT/US2019/052192 patent/WO2020061474A1/en active Application Filing
-
2021
- 2021-03-10 IL IL281405A patent/IL281405A/en unknown
- 2021-03-17 CL CL2021000660A patent/CL2021000660A1/es unknown
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