JPWO2019242339A5 - - Google Patents
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- JPWO2019242339A5 JPWO2019242339A5 JP2020571580A JP2020571580A JPWO2019242339A5 JP WO2019242339 A5 JPWO2019242339 A5 JP WO2019242339A5 JP 2020571580 A JP2020571580 A JP 2020571580A JP 2020571580 A JP2020571580 A JP 2020571580A JP WO2019242339 A5 JPWO2019242339 A5 JP WO2019242339A5
- Authority
- JP
- Japan
- Prior art keywords
- scfv
- antibody
- intracellular domain
- cd3zeta
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000700605 Viruses Species 0.000 claims description 44
- 230000003834 intracellular effect Effects 0.000 claims description 27
- 210000004027 cell Anatomy 0.000 claims description 24
- 239000013598 vector Substances 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 238000010276 construction Methods 0.000 claims description 9
- 102000037865 fusion proteins Human genes 0.000 claims description 9
- 108020001507 fusion proteins Proteins 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims description 9
- 239000013612 plasmid Substances 0.000 claims description 9
- 239000006228 supernatant Substances 0.000 claims description 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 102000005962 receptors Human genes 0.000 claims description 7
- 108020003175 receptors Proteins 0.000 claims description 7
- 108091008146 restriction endonucleases Proteins 0.000 claims description 7
- 101001043810 Macaca fascicularis Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 6
- 238000012761 co-transfection Methods 0.000 claims description 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 4
- 102100038077 CD226 antigen Human genes 0.000 claims description 3
- 102100027207 CD27 antigen Human genes 0.000 claims description 3
- 108010029697 CD40 Ligand Proteins 0.000 claims description 3
- 102100032937 CD40 ligand Human genes 0.000 claims description 3
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 3
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims description 3
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 3
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims description 3
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims description 3
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims description 3
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 3
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims description 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 3
- -1 LIGHT Proteins 0.000 claims description 3
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 3
- 102000008115 Signaling Lymphocytic Activation Molecule Family Member 1 Human genes 0.000 claims description 3
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 3
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 3
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 3
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims description 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 3
- 108091008034 costimulatory receptors Proteins 0.000 claims description 3
- 108010057085 cytokine receptors Proteins 0.000 claims description 3
- 102000003675 cytokine receptors Human genes 0.000 claims description 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 238000010367 cloning Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810636414.1 | 2018-06-20 | ||
| CN201810636414.1A CN110615843B (zh) | 2018-06-20 | 2018-06-20 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| PCT/CN2019/077923 WO2019242339A1 (zh) | 2018-06-20 | 2019-03-13 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529176A JP2021529176A (ja) | 2021-10-28 |
| JPWO2019242339A5 true JPWO2019242339A5 (zh) | 2023-05-23 |
| JP7433656B2 JP7433656B2 (ja) | 2024-02-20 |
Family
ID=68920806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020571580A Active JP7433656B2 (ja) | 2018-06-20 | 2019-03-13 | 第３シグナル受容体を含むキメラ抗原受容体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11524034B2 (zh) |
| EP (1) | EP3812401A4 (zh) |
| JP (1) | JP7433656B2 (zh) |
| KR (1) | KR20210023991A (zh) |
| CN (3) | CN110615843B (zh) |
| WO (1) | WO2019242339A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| CN115698062A (zh) * | 2020-04-06 | 2023-02-03 | 细胞编辑有限责任公司 | 表达嵌合抗原受体并具有降低的促炎细胞因子信号传导的经基因修饰的免疫细胞 |
| CN111518219B (zh) * | 2020-05-08 | 2021-06-22 | 浙江大学 | 嵌合性抗原受体及表达其的巨噬细胞、调节巨噬细胞极化的方法和应用 |
| CN112062864A (zh) * | 2020-09-18 | 2020-12-11 | 樊克兴 | 靶向bcma肿瘤抗原受体修饰t细胞的制备方法和应用 |
| WO2023274355A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海交通大学 | 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤 |
| WO2023044453A1 (en) * | 2021-09-17 | 2023-03-23 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptors comprising interleukin-9 receptor signaling domain |
| AU2023204767A1 (en) * | 2022-01-10 | 2024-08-29 | Michael Briskin | Anti-collagen triple helix repeat containing 1 (cthrc1) antibodies and methods of using the same |
| WO2024140501A1 (zh) * | 2022-12-27 | 2024-07-04 | 广州瑞风生物科技有限公司 | 一种融合蛋白及其应用 |
| CN117402231B (zh) * | 2023-12-14 | 2024-04-09 | 南方医科大学南方医院 | 一种自发传递il-21信号的受体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2694640T3 (da) * | 2011-04-08 | 2017-11-20 | Baylor College Medicine | Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer |
| WO2014055668A1 (en) * | 2012-10-02 | 2014-04-10 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| CN106279434B (zh) * | 2014-02-24 | 2020-07-03 | 西比曼生物科技（上海）有限公司 | 工程化cd20靶向性的nkt细胞及其制备方法和应用 |
| JP6846352B2 (ja) * | 2015-02-12 | 2021-03-24 | ユニバーシティー ヘルス ネットワーク | キメラ抗原受容体 |
| US11248058B2 (en) * | 2015-02-19 | 2022-02-15 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| CN108025024B (zh) * | 2015-07-28 | 2022-11-29 | 宾夕法尼亚大学董事会 | 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途 |
| GB201514875D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201518816D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| PT3436079T (pt) * | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| CN105949317B (zh) * | 2016-04-12 | 2019-07-02 | 上海优卡迪生物医药科技有限公司 | 抗cd20嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用 |
| CN105777911B (zh) * | 2016-04-12 | 2019-07-02 | 上海优卡迪生物医药科技有限公司 | 抗bcma嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用 |
| JP7198670B2 (ja) * | 2016-04-20 | 2023-01-04 | フレッド ハッチンソン キャンサー センター | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
| CN106397608A (zh) * | 2016-10-19 | 2017-02-15 | 中国医学科学院血液病医院（血液学研究所） | Cd20特异性嵌合抗原受体及其应用 |
| KR20240046620A (ko) * | 2016-11-17 | 2024-04-09 | 2세븐티 바이오, 인코포레이티드 | TGFβ 신호 컨버터 |
| CN107058234B (zh) * | 2017-05-12 | 2019-09-13 | 常州市第一人民医院 | Car.il-33-t及其制备与应用 |
| CN107245106B (zh) * | 2017-07-18 | 2020-06-12 | 深圳市免疫基因治疗研究院 | 一种基于cd10的嵌合抗原受体及其应用 |
| CN107384870A (zh) * | 2017-07-31 | 2017-11-24 | 时力生物科技（北京）有限公司 | 一种靶向pd‑l1嵌合抗原受体修饰的t淋巴细胞及其制备方法和应用 |
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
-
2018
- 2018-06-20 CN CN201810636414.1A patent/CN110615843B/zh active Active
-
2019
- 2019-03-13 WO PCT/CN2019/077923 patent/WO2019242339A1/zh unknown
- 2019-03-13 EP EP19823459.3A patent/EP3812401A4/en active Pending
- 2019-03-13 KR KR1020217001094A patent/KR20210023991A/ko not_active Application Discontinuation
- 2019-03-13 CN CN201980041282.0A patent/CN112673025B/zh active Active
- 2019-03-13 CN CN202210196195.6A patent/CN114516922A/zh active Pending
- 2019-03-13 JP JP2020571580A patent/JP7433656B2/ja active Active
-
2020
- 2020-12-18 US US17/127,283 patent/US11524034B2/en active Active
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