JPWO2019241002A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019241002A5 JPWO2019241002A5 JP2020569001A JP2020569001A JPWO2019241002A5 JP WO2019241002 A5 JPWO2019241002 A5 JP WO2019241002A5 JP 2020569001 A JP2020569001 A JP 2020569001A JP 2020569001 A JP2020569001 A JP 2020569001A JP WO2019241002 A5 JPWO2019241002 A5 JP WO2019241002A5
- Authority
- JP
- Japan
- Prior art keywords
- heavy chain
- variable domain
- transgenic
- transgenic chicken
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000287828 Gallus gallus Species 0.000 claims description 39
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 18
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 18
- 108090001123 antibodies Proteins 0.000 claims description 13
- 102000004965 antibodies Human genes 0.000 claims description 13
- 210000003719 B-Lymphocytes Anatomy 0.000 claims description 11
- 235000001014 amino acid Nutrition 0.000 claims description 11
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 6
- 102000038129 antigens Human genes 0.000 claims description 6
- 108091007172 antigens Proteins 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 229920001405 Coding region Polymers 0.000 claims description 4
- 102000018358 Immunoglobulins Human genes 0.000 claims description 4
- 108060003951 Immunoglobulins Proteins 0.000 claims description 4
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 108010045030 monoclonal antibodies Proteins 0.000 claims description 4
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 210000004027 cells Anatomy 0.000 claims description 2
- 230000000875 corresponding Effects 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 102000005614 monoclonal antibodies Human genes 0.000 claims description 2
- 108091008117 polyclonal antibodies Proteins 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 210000004408 Hybridomas Anatomy 0.000 description 4
- 230000002068 genetic Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684669P | 2018-06-13 | 2018-06-13 | |
| US62/684,669 | 2018-06-13 | ||
| PCT/US2019/035540 WO2019241002A1 (en) | 2018-06-13 | 2019-06-05 | Transgenic chicken that makes antibodies with long cdr-h3s stabilized by multiple disulfide bridges and diversified by gene conversion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021526830A JP2021526830A (ja) | 2021-10-11 |
| JPWO2019241002A5 true JPWO2019241002A5 (ru) | 2022-06-09 |
Family
ID=68842113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569001A Pending JP2021526830A (ja) | 2018-06-13 | 2019-06-05 | 複数のジスルフィド架橋によって安定化され、遺伝子変換によって多様化された長いｃｄｒ−ｈ３ｓで抗体を作製するトランスジェニックニワトリ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210230253A1 (ru) |
| EP (1) | EP3813520A4 (ru) |
| JP (1) | JP2021526830A (ru) |
| KR (1) | KR20210021002A (ru) |
| AU (1) | AU2019284256A1 (ru) |
| CA (1) | CA3102125A1 (ru) |
| WO (1) | WO2019241002A1 (ru) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO2008151081A1 (en) * | 2007-06-01 | 2008-12-11 | Omt, Inc. | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
| GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| AU2010282508B2 (en) * | 2009-08-13 | 2015-05-28 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRs |
| SI2509409T1 (sl) * | 2009-12-10 | 2016-12-30 | Regeneron Pharmaceuticals, Inc. | Miši, ki tvorijo protitelesa težke verige |
| US9394372B2 (en) * | 2011-10-21 | 2016-07-19 | Crystal Bioscience Inc. | In vivo method for generating diversity in a protein scaffold |
| JP6684490B2 (ja) * | 2012-01-09 | 2020-04-22 | ザ・スクリップス・リサーチ・インスティテュート | 超長相補性決定領域及びその使用 |
| CN111518199A (zh) * | 2013-07-18 | 2020-08-11 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
| EP3851453A1 (en) * | 2014-05-02 | 2021-07-21 | Chiome Bioscience Inc. | Cells for producing human antibody |
-
2019
- 2019-06-05 US US15/734,955 patent/US20210230253A1/en active Pending
- 2019-06-05 JP JP2020569001A patent/JP2021526830A/ja active Pending
- 2019-06-05 EP EP19819135.5A patent/EP3813520A4/en active Pending
- 2019-06-05 CA CA3102125A patent/CA3102125A1/en active Pending
- 2019-06-05 KR KR1020217000705A patent/KR20210021002A/ko unknown
- 2019-06-05 WO PCT/US2019/035540 patent/WO2019241002A1/en unknown
- 2019-06-05 AU AU2019284256A patent/AU2019284256A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5756802B2 (ja) | 最小ｃｄｒを有する抗体を産生するトランスジェニック動物 | |
| HRP20200093T1 (hr) | Humanizirane neljudske životinje s ograničenim lokusima imunoglobulinskog teškog lanca | |
| RU2020127564A (ru) | Продуцирующие антитела млекопитающие, не являющиеся человеком | |
| RU2625033C2 (ru) | Система индикации на основе полноразмерного антитела для эукариотических клеток и ее применение | |
| JP2015519076A5 (ru) | ||
| JP2013532974A5 (ru) | ||
| JP2020530760A5 (ru) | ||
| KR20110089846A (ko) | 키메라 항체의 제조를 위한 인간 이외의 포유동물 | |
| HRP20201403T1 (hr) | Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca | |
| JP2011182801A5 (ru) | ||
| CN109810188A (zh) | 用于克隆和表达关联抗体可变区基因区段的快速方法 | |
| TR201906650T4 (tr) | Ortak hafif zincirli fare. | |
| CA2532117A1 (en) | Humanized immunoglobulin loci | |
| JP6731702B2 (ja) | 親和性成熟化ヒト抗体の同定 | |
| JP2010527622A5 (ru) | ||
| KR20210133234A (ko) | 인간화 면역글로불린 유전자좌를 갖는 유전적으로 변형된 비-인간 동물 | |
| JP2010517530A (ja) | 高産生細胞株の選択 | |
| Zou et al. | Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice | |
| JP2018537968A (ja) | 共通軽鎖を有するトランスジェニックウサギ | |
| CN116194586A (zh) | 一种非人哺乳动物或其子代的制备方法及其应用 | |
| CN112004411B (zh) | 产生人抗体的转基因鸡 | |
| Ching et al. | Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics | |
| JPWO2019241002A5 (ru) | ||
| WO2022248445A1 (en) | Animal models and therapeutic molecules | |
| JPWO2019240998A5 (ru) |