JPWO2019222479A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019222479A5 JPWO2019222479A5 JP2020564156A JP2020564156A JPWO2019222479A5 JP WO2019222479 A5 JPWO2019222479 A5 JP WO2019222479A5 JP 2020564156 A JP2020564156 A JP 2020564156A JP 2020564156 A JP2020564156 A JP 2020564156A JP WO2019222479 A5 JPWO2019222479 A5 JP WO2019222479A5
- Authority
- JP
- Japan
- Prior art keywords
- strand
- alkyl
- dsrna
- modified
- dsrna molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023189998A JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862672405P | 2018-05-16 | 2018-05-16 | |
| US62/672,405 | 2018-05-16 | ||
| US201862719291P | 2018-08-17 | 2018-08-17 | |
| US62/719,291 | 2018-08-17 | ||
| PCT/US2019/032633 WO2019222479A1 (en) | 2018-05-16 | 2019-05-16 | Modified rna agents with reduced off-target effect |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189998A Division JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021523720A JP2021523720A (ja) | 2021-09-09 |
| JP2021523720A5 JP2021523720A5 (https=) | 2022-05-24 |
| JPWO2019222479A5 true JPWO2019222479A5 (https=) | 2022-05-24 |
| JP7384833B2 JP7384833B2 (ja) | 2023-11-21 |
Family
ID=68540971
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564156A Active JP7384833B2 (ja) | 2018-05-16 | 2019-05-16 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2023189998A Active JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A Pending JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189998A Active JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A Pending JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US12247203B2 (https=) |
| EP (1) | EP3802827A4 (https=) |
| JP (3) | JP7384833B2 (https=) |
| AU (2) | AU2019270152B2 (https=) |
| CA (1) | CA3099930A1 (https=) |
| WO (1) | WO2019222479A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| WO2019217459A1 (en) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| WO2021178607A1 (en) * | 2020-03-05 | 2021-09-10 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| TW202214858A (zh) * | 2020-08-04 | 2022-04-16 | 大陸商上海拓界生物醫藥科技有限公司 | 脫靶活性降低的修飾siRNA |
| WO2022174000A2 (en) | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| CN113073098B (zh) * | 2021-02-20 | 2024-08-20 | 北京理工大学 | 抑制BACE1基因表达的siRNA修饰物及其应用 |
| WO2022212231A2 (en) | 2021-03-29 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| KR20240067943A (ko) | 2021-09-24 | 2024-05-17 | 알닐람 파마슈티칼스 인코포레이티드 | 미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법 |
| EP4493570A2 (en) | 2022-03-16 | 2025-01-22 | Empirico Inc. | Galnac compositions for improving sirna bioavailability |
| KR20240163743A (ko) | 2022-03-28 | 2024-11-19 | 엠피리코 인크. | 변형된 올리고뉴클레오티드 |
| JP2025524135A (ja) * | 2022-07-27 | 2025-07-25 | イー－セラピューティクス・ピーエルシー | 核酸化合物 |
| JP2025532985A (ja) * | 2022-09-30 | 2025-10-03 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 修飾二本鎖ｒｎａ剤 |
| WO2024217152A2 (zh) * | 2023-04-21 | 2024-10-24 | 苏州时安生物技术有限公司 | 一种寡聚核酸及其制备方法和应用 |
| WO2025064821A2 (en) | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| US12454693B1 (en) * | 2024-09-27 | 2025-10-28 | Dexcel Pharma Technologies Ltd. | Nucleic acids for inhibiting expression of transferrin receptor 2 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032069A1 (en) * | 2002-11-05 | 2005-02-10 | Muthiah Manoharan | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation |
| US7812149B2 (en) * | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
| EP2152877A2 (en) | 2007-05-02 | 2010-02-17 | Sirna Therapeutics Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE ( PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012528596A (ja) | 2009-06-03 | 2012-11-15 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | ペプチドダイサー基質剤およびその特異的な遺伝子発現阻害のための方法 |
| US10913767B2 (en) | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| US20130190383A1 (en) | 2010-04-26 | 2013-07-25 | Marina Biotech, Inc. | Nucleic acid compounds with conformationally restricted monomers and uses thereof |
| WO2015106128A2 (en) * | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| JP7105065B2 (ja) * | 2014-12-15 | 2022-07-22 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | リガンド修飾二本鎖核酸 |
| WO2016209862A1 (en) | 2015-06-23 | 2016-12-29 | Alnylam Pharmaceuticals, Inc. | Glucokinase (gck) irna compositions and methods of use thereof |
| JP6924744B2 (ja) | 2015-07-17 | 2021-08-25 | アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｂ型肝炎ウイルスに対する組成物および薬剤ならびにその使用 |
| KR102645243B1 (ko) * | 2016-11-23 | 2024-03-11 | 알닐람 파마슈티칼스 인코포레이티드 | 표적외 효과가 감소된 변형 rna 작용제 |
-
2019
- 2019-05-16 WO PCT/US2019/032633 patent/WO2019222479A1/en not_active Ceased
- 2019-05-16 JP JP2020564156A patent/JP7384833B2/ja active Active
- 2019-05-16 AU AU2019270152A patent/AU2019270152B2/en active Active
- 2019-05-16 CA CA3099930A patent/CA3099930A1/en active Pending
- 2019-05-16 EP EP19803000.9A patent/EP3802827A4/en active Pending
- 2019-05-16 US US17/055,710 patent/US12247203B2/en active Active
-
2022
- 2022-05-13 US US17/743,663 patent/US12275938B2/en active Active
-
2023
- 2023-11-07 JP JP2023189998A patent/JP7684373B2/ja active Active
-
2024
- 2024-12-04 US US18/968,749 patent/US20250207131A1/en active Pending
-
2025
- 2025-05-01 JP JP2025076285A patent/JP2025113272A/ja active Pending
- 2025-07-22 AU AU2025206406A patent/AU2025206406A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021523720A5 (https=) | ||
| JPWO2019222479A5 (https=) | ||
| CN109890207B (zh) | 包含可逆修饰的寡核苷酸的组合物及其用途 | |
| JP7798836B2 (ja) | Ｂ型肝炎感染の治療用のＰＡＰＤ５及びＰＡＰＤ７ ｍＲＮＡを低減させるための核酸分子 | |
| US20230287418A1 (en) | Modified sirna with reduced off-target activity | |
| BR112021008539A2 (pt) | polímeros de oligonucleotídeos e métodos de inibição de transporte de antígeno s | |
| CN116514890A (zh) | 用于B型肝炎病毒感染的RNAi剂 | |
| CN110475784B (zh) | 用于制备立体限定硫代磷酸酯寡核苷酸的正交保护基 | |
| IL316808A (en) | Modified double-stranded RNA materials and their uses | |
| CN118355121A (zh) | 一种dsRNA、其制备方法及应用 | |
| CN121194983A (zh) | 5'-膦酸酯修饰的核苷类似物及其制备的寡核苷酸 | |
| CN116854753B (zh) | 一种化合物、缀合物、组合物以及它们的用途 | |
| WO2023131170A1 (zh) | 具有核苷酸类似物的双链rna | |
| CN121816417A (zh) | 双链寡核苷酸药剂和其用途 | |
| EP2854813B1 (en) | Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them | |
| CN121532510A (zh) | Cfb抑制剂组合物及其应用 | |
| JPWO2019175260A5 (https=) | ||
| BR112020012427A2 (pt) | oligonucleotídeo, sal farmaceuticamente aceitável, conjugado, composição farmacêutica, processo para a fabricação de um oligonucleotídeo, oligonucleotídeo fabricado e invenção | |
| JPWO2020146521A5 (https=) | ||
| JPWO2021072395A5 (https=) | ||
| WO2025201529A1 (en) | Compounds for synthesizing modified small activating rna molecules, modified small activating rna molecules and uses thereof | |
| CN111378658B (zh) | 抑制TIMP-1基因表达的siRNA、含有该siRNA的药物组合物及其用途 | |
| JP2024518564A (ja) | 中枢神経系のニューロンを標的とするための脂質コンジュゲーション | |
| JP2023127483A (ja) | ２’位にアミノスルホニルアルコキシ基を有する新規人工核酸 | |
| Rejman et al. | Synthesis of 4'-N pyrrolidine nucleosides, nucleotides, and oligonucleotides |