JP7384833B2 - オフターゲット効果が低下した修飾ｒｎａ剤 - Google Patents
オフターゲット効果が低下した修飾ｒｎａ剤 Download PDFInfo
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- JP7384833B2 JP7384833B2 JP2020564156A JP2020564156A JP7384833B2 JP 7384833 B2 JP7384833 B2 JP 7384833B2 JP 2020564156 A JP2020564156 A JP 2020564156A JP 2020564156 A JP2020564156 A JP 2020564156A JP 7384833 B2 JP7384833 B2 JP 7384833B2
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- dsrna
- antisense strand
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| US10913767B2 (en) | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| US20130190383A1 (en) | 2010-04-26 | 2013-07-25 | Marina Biotech, Inc. | Nucleic acid compounds with conformationally restricted monomers and uses thereof |
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| KR102645243B1 (ko) * | 2016-11-23 | 2024-03-11 | 알닐람 파마슈티칼스 인코포레이티드 | 표적외 효과가 감소된 변형 rna 작용제 |
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| WO2015106128A2 (en) | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| JP2017525705A (ja) | 2014-08-20 | 2017-09-07 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 修飾二本鎖ｒｎａ剤 |
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| WO2019222479A1 (en) | 2019-11-21 |
| CA3099930A1 (en) | 2019-11-21 |
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