JPWO2019212984A5 - - Google Patents
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本発明の一態様に準拠して、斜角を有する非外傷性のナビゲーション用先端部を有する神経血管カテーテルが提供される。このカテーテルは、近位端と、遠位端と、中央管腔を画定する側壁とを有する細長い可撓性の管状体を含む。管状体の遠位ゾーンは、管状の内側ライナと；内側ライナを取り囲み、遠位端を有するらせん状コイルと；らせん状コイルを取り囲む管状ジャケットであって、らせん状コイル遠位端を越えて遠位に延びて、カテーテルの遠位面で終端する管状ジャケットと、を含む。管状の放射線不透過性マーカが、コイルの遠位端と遠位面との間の管状ジャケット内に埋め込まれている。遠位面は、約３５度から約５５度の範囲内の角度で管状体の長手方向軸を横切る平面上に存在し；マーカは、長手方向軸に対してほぼ垂直な近位面と、約３５度から約５５度の範囲内の角度で長手方向軸を横切る平面上に存在する遠位面とを有している。遠位面は、管状体の後方端から遠位に延びる、管状体の前方端を画定し、前方端およびトレーニングエッジ（ｔｒａｉｎｉｎｇ ｅｄｇｅ）は、長手方向軸の周りに互いに約１８０度離間している。 In accordance with one aspect of the invention, a neurovascular catheter is provided having a beveled atraumatic navigation tip. The catheter includes an elongated flexible tubular body having a proximal end, a distal end, and a sidewall defining a central lumen. The distal zone of the tubular body includes: a tubular inner liner; a helical coil surrounding the inner liner and having a distal end; a tubular jacket surrounding the helical coil and having a distal end extending beyond the helical coil distal end; a tubular jacket extending to the catheter and terminating at the distal surface of the catheter. A tubular radiopaque marker is embedded within the tubular jacket between the distal end and the distal surface of the coil. The distal surface lies on a plane that intersects the longitudinal axis of the tubular body at an angle within the range of about 35 degrees to about 55 degrees; the marker lies on a proximal surface that is generally perpendicular to the longitudinal axis; and a distal surface lying in a plane transverse to the longitudinal axis at an angle within the range of 35 degrees to about 55 degrees. The distal surface defines a forward end of the tubular body extending distally from the posterior end of the tubular body, and the forward end and the training edge are approximately 180 degrees apart from each other about the longitudinal axis. are doing.
管状体の前進区分は、マーカ帯を越えて遠位に延びる。前進区分は、管状体の前方端側で約１ｍｍから約３ｍｍの範囲内の軸方向長さを有してもよい。管状体の前方端側の前進区分の長さは、管状体の後方端側の前進区分の長さよりも大きくてもよい。 The advancement section of the tubular body extends distally beyond the marker band. The advancement section may have an axial length within the range of about 1 mm to about 3 mm at the forward end of the tubular body. The length of the advancing section at the forward end of the tubular body may be greater than the length of the advancing section at the rearward end of the tubular body.
管状体の前方端側のマーカ帯の軸方向長さは、管状体の後方端側のマーカ帯の軸方向の長さよりも少なくとも約２０％長くてもよい。管状体の前方端側のマーカ帯の軸方向長さは、約１ｍｍから約５ｍｍの範囲内であってもよい。マーカ帯は、少なくとも１つの軸方向スリットを含む。 The axial length of the marker strip on the forward end of the tubular body may be at least about 20% greater than the axial length of the marker strip on the aft end of the tubular body. The axial length of the marker band at the forward end of the tubular body may be in the range of about 1 mm to about 5 mm. The marker strip includes at least one axial slit.
本発明を、特定の好ましい実施形態に関して記載してきたが、これは、本明細書の開示に鑑み、当業者であれば他の実施形態に組み込むことができる。したがって、本発明の範囲は、本明細書に開示された特定の実施形態によって限定されることを意図するものではなく、以下の特許請求の範囲の最大限の範囲によって定義されることが意図される。
本発明は、以下の発明を含む。
［１］血管内部位から塞栓物質を除去するシステムであって、
近位端と、遠位端と、管状の側壁であって、その中を通って軸方向に延びる少なくとも１つの管腔を画定する管状の側壁とを有する、細長い可撓性の管状体と、
前記側壁によって支持され、前記管腔に露出している軸方向拘束装置と、
前記管腔を通って伸縮可能であり、近位端と遠位端とを有するコアワイヤと、
前記コアワイヤによって支持され、前記拘束装置と回転可能に係合する軸受け面を有する制限装置と、
前記コアワイヤの前記遠位端上の撹拌体先端部と、を含み、
前記制限装置と前記拘束装置が、前記コアワイヤの回転を許容するが、前記管状体に対して相対的に前記先端部の遠位前進を制限するように係合可能である、システム。
［２］前記軸方向拘束装置が、近位に面した軸受け面を含む、上記［１］に記載のシステム。
［３］前記軸方向拘束装置が、半径方向内側に延びる突出部を含む、上記［２］に記載のシステム。
［４］前記軸方向の拘束装置が、環状フランジを含む、上記［３］に記載のシステム。
［５］前記制限装置が、遠位に面した軸受け面を含む、上記［１］に記載のシステム。
［６］前記制限装置が、半径方向外側に延びる突出部を含む、上記［５］に記載のシステム。
［７］前記半径方向外側に延びる突出部が、前記管状の側壁の内面と摺動接触するように構成される摺動体を支持するスポークを含む、上記［６］に記載のシステム。
［８］前記摺動体をそれぞれ支持する３本のスポークを含む、上記［７］に記載のシステム。
［９］前記制限装置が、環状リングを含む、上記［６］に記載のシステム。
［１０］前記制限装置が、前記コアワイヤから半径方向外側に離間した環状リングを含む、上記［１］に記載のシステム。
［１１］前記コアワイヤと前記リングとの間に延びる少なくとも２本のスポークをさらに含む、上記［１０］に記載のシステム。
［１２］前記コアワイヤと前記リングとの間に延びる３本のスポークを含む、上記［１１］に記載のシステム。
［１３］スポークの各隣接する一対の間に、かつ前記中央管腔と連通して画定される流路を含む、上記［８］に記載のシステム。
［１４］３つの流路を含み、前記３つの流路の断面積の合計が、前記拘束装置の近位１ｃｍの範囲内の前記管腔の断面積の少なくとも約７５％である、上記［１３］に記載のシステム。
［１５］前記３つの流路の断面積の合計が、前記拘束装置の近位１ｃｍの範囲内の前記管腔の断面積の少なくとも約９０％である、上記［１４］に記載のシステム。
［１６］前記コアワイヤが、前記近位点での大きい方の直径から前記制限装置での前記大きい方の直径の約３０％以下の小さい方の直径までテーパ状になっている、上記［１］に記載のシステム。
［１７］前記コアワイヤが、前記制限装置での前記大きい方の直径の約１８％以下の小さい方の直径までテーパ状になっている、上記［１６］に記載のシステム。
［１８］前記コアワイヤが、前記近位点での約０．０２５インチの直径から前記制限装置での約０．００５インチ以下の直径までテーパ状になっている、上記［１７］に記載のシステム。
［１９］前記攪拌体の先端部が、らせん状ねじ山を含む、上記［１］に記載のシステム。
［２０］前記らせん状ねじ山が、前記管腔の内径の約９０％以下のねじ外径を有して、前記先端部と前記側壁の内面との間に環状流路を残す、上記［１９］に記載のシステム。
［２１］前記コアワイヤによって支持され、かつ約５ｃｍから約６０ｃｍまでの範囲内の長さで前記先端部から近位に延びるばねをさらに含む、上記［１６］に記載のシステム。
［２２］前記ばねが、約２０ｃｍから約４０ｃｍまでの範囲内の長さで前記先端部から近位に延びる、上記［２１］に記載のシステム。
［２３］前記らせん状ねじ山が、尖っていない外縁を有する、上記［１９］に記載のシステム。
［２４］前記制限装置が、前記カテーテル長の遠位約５０％以下の範囲内に位置している、上記［１］に記載のシステム。
［２５］前記制限装置が、前記カテーテル長の遠位約２５％以下の範囲内に位置している、上記［２４］に記載のシステム。
［２６］前記コアワイヤが、前記管状体の内部に取り外し可能に位置決め可能である、上記［１］に記載のシステム。
［２７］前記らせん状ねじ山が、軸方向に隣接するねじ山間のらせん状流路を画定し、前記らせん状流路の断面積と前記環状流路の断面積の和が、前記管腔の断面積の少なくとも約２０％である、上記［２０］に記載のシステム。
［２８］前記軸受け面が、蛇行した血管系内部への前記管状体の位置決めに応答して、前記攪拌体先端部の、前記管状体を越えての遠位前進を切り離す、上記［２５］に記載のシステム。
［２９］機械的かつ吸引による支援を用いて血管から塞栓物質を除去する方法であって、
中央管腔および遠位端を有する吸引カテーテルを提供するステップと、
前記遠位端を血管内の閉塞性物質まで前進させるステップと、
前記管腔内部で先端部を回転させるステップであって、前記先端部が、約５ｍｍ以下の軸方向長さと、前記管腔の内径よりも少なくとも約０．０１５インチ小さい外径を有するらせん状ねじ山とを有し、前記先端部の外側の周囲に吸引流路を設けるステップと、
前記管腔に真空を印加し、前記先端部を回転させて物質を管腔内に引き寄せるステップと、を含む、方法。
［３０］前記回転のステップが、前記カテーテル内を通じて延びるコアワイヤを手動で回転させ、前記先端部を回転させることを含む、上記［２９］に記載の方法。
［３１］前記中央管腔内に位置決めされた拘束装置に対して、前記コアワイヤによって支持される制限装置を回転させることによって、前記コアワイヤの遠位前進を制限するステップをさらに含む、上記［３０］に記載の方法。
［３２］遠隔部位から血管閉塞物を吸引する方法であって、
血管アクセス部位を通じて細長い管状体を血管閉塞物まで前進させるステップであって、前記管状体が、近位端と、遠位端と、中央管腔と、前記管状体から前記管腔内に延びる停止装置とを含むステップと、
回転可能なコアワイヤを、前記コアワイヤによって支持される制限装置が、前記停止装置に摺動可能に係合するまで、前記管腔内を通じて遠位方向に前進させて、前記管腔内部での前記コアワイヤのさらなる遠位前進を制限する回転可能な軸受けを提供するステップ
と、
前記管腔に真空を印加し、前記コアワイヤを回転させて血栓を前記管腔内に引き寄せるステップと、
を含む、遠隔部位から血管閉塞物を吸引する方法。
［３３］前記真空を印加するステップが、パルス性の真空を印加することを含む、上記［３２］に記載の血管閉塞物を吸引する方法。
［３４］前記細長い管状体を前進させるステップが、前記管状体のいかなる介在もなしにガイドワイヤにわたって直接達成される、上記［３２］に記載の血管閉塞物を吸引する方法。
［３５］前記管状体を、少なくとも内頸動脈の海綿質区分まで遠位に前進させることを含む、上記［３２］に記載の血管閉塞物を吸引する方法。
［３６］前記管状体を、少なくとも内頸動脈の脳区分まで遠位に前進させることを含む、上記［３２］に記載の血管閉塞物を吸引する方法。
［３７］前記回転可能なコアワイヤを前進させるステップが、細長い管状体を、血管アクセス部位を通じて血管閉塞物まで前進させるステップの後に達成される、上記［３２］に記載の血管閉塞物を吸引する方法。
［３８］前記回転可能なコアワイヤを前進させるステップが、前記細長い管状体を、血管アクセス部位内を通じて血管閉塞物まで前進させるステップと同時に達成される、上記［３２］に記載の血管閉塞物を吸引する方法。
［３９］非外傷性ナビゲーション用先端部を有する神経血管カテーテルであって、
近位端と、遠位端と、中央管腔を画定する側壁とを有する細長い可撓性の管状体を含み、前記管状体の遠位ゾーンが、
管状の内側ライナと、
前記内側ライナを取り囲み、遠位端を有するらせん状コイルと；
前記らせん状コイルを取り囲み、前記らせん状コイルの遠位端を越えて遠位に延びて、カテーテルの遠位面で終端する管状ジャケットと、
前記コイルの遠位端と前記遠位面との間で前記管状ジャケット内に埋め込まれた管状の放射線不透過性マーカと、を含み、
前記遠位面が、約３５度から約５５度までの範囲内の角度で前記管状体の長手方向軸を横切る平面上に存在し、
前記マーカが、前記長手方向軸に対してほぼ垂直な近位面と、約３５度から約５５度までの範囲内の角度で前記長手方向軸を横切る平面上に存在する遠位面とを有する、神経血管カテーテル。
［４０］前記遠位面が、前記管状体の後方端から遠位に延びる前記管状体の前方端を画定し、前記前方端および後方端が、長手方向軸の周りで互いから約１８０度離間している、上記［３９］に記載の神経血管カテーテル。
［４１］前記管状体の前進区分が、前記マーカ帯を越えて遠位に延びる、上記［４０］に記載の神経血管カテーテル。
［４２］前記前進区分が、前記管状体の前記前方端側の約１ｍｍから約３ｍｍまでの範囲内の軸方向長さを有する、上記［４１］に記載の神経血管カテーテル。
［４３］前記管状体の前記前方端側の前進区分の長さが、前記管状体の前記後方端側の前進区分の長さよりも大きい、上記［４０］に記載の神経血管カテーテル。
［４４］前記管状体の前記前方端側のマーカ帯の軸方向長さが、前記管状体の前記後方端側のマーカ帯の軸方向長さよりも少なくとも約２０％長い、上記［４０］に記載の神経血管カテーテル。
［４５］前記管状体の前記前方端側のマーカ帯の軸方向長さが、約１ｍｍから約５ｍｍまでの範囲内である、上記［４４］に記載の神経血管カテーテル。
［４６］前記マーカ帯が、少なくとも１つの軸方向スリットを含む、上記［４０］に記載の神経血管カテーテル。
［４７］前記管状ライナが、取り外し可能なマンドレルを浸漬塗布することによって形成される、上記［４０］に記載の神経血管カテーテル。
［４８］前記管状ライナがＰＴＦＥを含む、上記［４７］に記載の神経血管カテーテル。
［４９］前記内側ライナと前記らせん状コイルとの間に結束層をさらに含む、上記［４０］に記載の神経血管カテーテル。
［５０］前記結束層が約０．００５インチ以下の壁厚を有する、上記［４９］に記載の神経血管カテーテル。
［５１］前記結束層が、前記可撓体の少なくとも最遠位の２０ｃｍに沿って延びる、上記［５０］に記載の神経血管カテーテル。
［５２］前記コイルがニチノール（Ｎｉｔｉｎｏｌ）を含む、上記［４０］に記載の神経血管カテーテル。
［５３］前記ニチノールが、体温でオーステナイト（Ａｕｓｔｅｎｉｔｅ）状態を含む、上記［５２］に記載の神経血管カテーテル。
［５４］前記外側ジャケットが、軸方向に隣接する少なくとも５つの離散的な管状区分から形成される、上記［３９］に記載の神経血管カテーテル。
［５５］前記外側ジャケットが、軸方向に隣接する少なくとも９つの離散的な管状区分から形成される、上記［５４］に記載の神経血管カテーテル。
［５６］前記管状区分の近位のものと前記管状区分の遠位のものとの間のデュロメータの差が、少なくとも約２０Ｄである、上記［５４］に記載の神経血管カテーテル。
［５７］前記管状区分の近位のものと前記管状区分の遠位のものとの間のデュロメータの差が、少なくとも約３０Ｄである、上記［５６］に記載の神経血管カテーテル。
［５８］前記遠位ゾーンの張力抵抗を増加させる張力支持体をさらに含む、上記［４０］に記載の神経血管カテーテル。
［５９］前記張力支持体が、軸方向に延びるフィラメントを含む、上記［５８］に記載の可撓性を強化させた神経血管カテーテル。
［６０］前記軸方向に延びるフィラメントが、前記内側ライナと前記らせん状コイルとの間に支持される、上記［５９］に記載の神経血管カテーテル。
［６１］前記軸方向に延びるフィラメントが、前記管状体の引張強度を少なくとも約２ポンドまで増加させる、上記［５９］に記載の神経血管カテーテル。
Although the invention has been described with respect to certain preferred embodiments, it can be incorporated into other embodiments by those skilled in the art in light of the disclosure herein. Accordingly, the scope of the invention is not intended to be limited by the particular embodiments disclosed herein, but is intended to be defined by the fullest scope of the following claims. Ru.
The present invention includes the following inventions.
[1] A system for removing embolic material from an intravascular site, the system comprising:
an elongated flexible tubular body having a proximal end, a distal end, and a tubular sidewall defining at least one lumen extending axially therethrough;
an axial restraint supported by the sidewall and exposed to the lumen;
a core wire extendable through the lumen and having a proximal end and a distal end;
a restriction device supported by the core wire and having a bearing surface rotatably engaged with the restraint device;
a stirrer tip on the distal end of the core wire;
The system wherein the restriction device and the restraint device are engageable to permit rotation of the core wire but limit distal advancement of the tip relative to the tubular body.
[2] The system of [1] above, wherein the axial restraint device includes a proximally facing bearing surface.
[3] The system according to [2] above, wherein the axial restraint device includes a protrusion that extends radially inward.
[4] The system according to [3] above, wherein the axial restraint device includes an annular flange.
[5] The system of [1] above, wherein the restriction device includes a distally facing bearing surface.
[6] The system according to [5] above, wherein the restriction device includes a radially outwardly extending protrusion.
[7] The system according to [6] above, wherein the radially outwardly extending protrusion includes a spoke supporting a slide configured to be in sliding contact with an inner surface of the tubular side wall.
[8] The system according to [7] above, including three spokes that respectively support the sliding bodies.
[9] The system according to [6] above, wherein the restriction device includes an annular ring.
[10] The system of [1] above, wherein the restriction device includes an annular ring spaced radially outwardly from the core wire.
[11] The system according to [10] above, further comprising at least two spokes extending between the core wire and the ring.
[12] The system according to [11] above, including three spokes extending between the core wire and the ring.
[13] The system according to [8] above, including a flow path defined between each adjacent pair of spokes and in communication with the central lumen.
[14] [13] above, comprising three channels, the sum of the cross-sectional areas of the three channels being at least about 75% of the cross-sectional area of the lumen within 1 cm proximal to the restraint device. The system described in ].
[15] The system of [14] above, wherein the sum of the cross-sectional areas of the three channels is at least about 90% of the cross-sectional area of the lumen within 1 cm proximal to the restraint device.
[16] The core wire tapers from a larger diameter at the proximal point to a smaller diameter that is no more than about 30% of the larger diameter at the restriction device. system described in.
[17] The system of [16] above, wherein the core wire tapers to a smaller diameter that is no more than about 18% of the larger diameter at the restriction device.
[18] The system of [17], wherein the core wire tapers from a diameter of about 0.025 inches at the proximal point to a diameter of about 0.005 inches or less at the restriction device. .
[19] The system according to [1] above, wherein the tip of the stirring body includes a helical thread.
[20] The above-mentioned [19], wherein the helical thread has a thread outer diameter that is about 90% or less of the inner diameter of the lumen, leaving an annular flow path between the tip and the inner surface of the side wall. The system described in ].
[21] The system of [16], further comprising a spring supported by the core wire and extending proximally from the tip for a length within the range of about 5 cm to about 60 cm.
[22] The system of [21] above, wherein the spring extends proximally from the tip for a length in the range of about 20 cm to about 40 cm.
[23] The system according to [19] above, wherein the helical thread has a blunt outer edge.
[24] The system according to [1] above, wherein the restriction device is located within about 50% or less of the distal length of the catheter.
[25] The system of [24] above, wherein the restriction device is located within about 25% or less of the distal length of the catheter.
[26] The system according to [1] above, wherein the core wire is removably positionable inside the tubular body.
[27] The helical thread defines a helical flow path between axially adjacent threads, and the sum of the cross-sectional area of the helical flow path and the cross-sectional area of the annular flow path is equal to The system according to [20] above, wherein the cross-sectional area is at least about 20%.
[28] The bearing surface decouples distal advancement of the stirrer tip beyond the tubular body in response to positioning of the tubular body within a tortuous vasculature. The system described.
[29] A method for removing embolic material from a blood vessel using mechanical and suction assistance, the method comprising:
providing an aspiration catheter having a central lumen and a distal end;
advancing the distal end to an occlusive material within a blood vessel;
rotating a tip within the lumen, the tip having an axial length of about 5 mm or less and an outer diameter of at least about 0.015 inch less than the inner diameter of the lumen; and providing a suction channel around the outside of the tip;
applying a vacuum to the lumen and rotating the tip to draw material into the lumen.
[30] The method of [29] above, wherein the rotating step includes manually rotating a core wire extending through the catheter to rotate the tip.
[31] [30] above, further comprising limiting distal advancement of the core wire by rotating a restriction device supported by the core wire relative to a restraint device positioned within the central lumen. The method described in.
[32] A method of suctioning a vascular occlusion from a remote site, the method comprising:
advancing an elongated tubular body through a vascular access site to a vascular occlusion, the tubular body having a proximal end, a distal end, a central lumen, and a stop extending from the tubular body into the lumen; a step comprising: an apparatus;
A rotatable core wire is advanced distally through the lumen until a restriction device supported by the core wire slidably engages the stop device, and the core wire is moved inside the lumen. providing a rotatable bearing to limit further distal advancement of the
applying a vacuum to the lumen and rotating the core wire to draw the thrombus into the lumen;
A method of aspirating a vascular occlusion from a remote site, including:
[33] The method for aspirating a vascular occlusion according to [32] above, wherein the step of applying a vacuum includes applying a pulsed vacuum.
[34] The method of aspirating a vascular occlusion according to [32] above, wherein the step of advancing the elongated tubular body is accomplished directly over a guidewire without any intervention of the tubular body.
[35] The method for aspirating a vascular occlusion according to [32] above, comprising advancing the tubular body distally to at least the cancellous segment of the internal carotid artery.
[36] The method for aspirating a vascular occlusion according to [32] above, comprising advancing the tubular body distally to at least the cerebral segment of the internal carotid artery.
[37] The method of aspirating a vascular occlusion according to [32] above, wherein the step of advancing the rotatable core wire is accomplished after the step of advancing the elongated tubular body through the vascular access site to the vascular occlusion. .
[38] Aspirating a vascular occlusion according to [32] above, wherein the step of advancing the rotatable core wire is accomplished simultaneously with the step of advancing the elongate tubular body through a vascular access site and to the vascular occlusion. how to.
[39] A neurovascular catheter having a tip for atraumatic navigation,
an elongated flexible tubular body having a proximal end, a distal end, and a sidewall defining a central lumen, the distal zone of the tubular body comprising:
a tubular inner liner;
a helical coil surrounding the inner liner and having a distal end;
a tubular jacket surrounding the helical coil and extending distally beyond the distal end of the helical coil and terminating at the distal face of the catheter;
a tubular radiopaque marker embedded within the tubular jacket between the distal end of the coil and the distal surface;
the distal surface lies in a plane transverse to the longitudinal axis of the tubular body at an angle within a range of about 35 degrees to about 55 degrees;
The marker has a proximal surface that is generally perpendicular to the longitudinal axis and a distal surface that lies in a plane that intersects the longitudinal axis at an angle within a range of about 35 degrees to about 55 degrees. , neurovascular catheter.
[40] The distal surface defines a forward end of the tubular body extending distally from a rearward end of the tubular body, the forward end and the aft end being spaced apart from each other about a longitudinal axis. The neurovascular catheter according to [39] above, which are spaced apart by about 180 degrees.
[41] The neurovascular catheter of [40] above, wherein the advancement section of the tubular body extends distally beyond the marker band.
[42] The neurovascular catheter of [41] above, wherein the advancement section has an axial length within the range of about 1 mm to about 3 mm on the forward end side of the tubular body.
[43] The neurovascular catheter according to [40], wherein the length of the advancing section on the front end side of the tubular body is greater than the length of the advancing section on the rear end side of the tubular body.
[44] [40] above, wherein the axial length of the marker band on the front end side of the tubular body is at least about 20% longer than the axial length of the marker band on the rear end side of the tubular body. The neurovascular catheter described in .
[45] The neurovascular catheter according to [44] above, wherein the axial length of the marker band on the front end side of the tubular body is within a range of about 1 mm to about 5 mm.
[46] The neurovascular catheter according to [40] above, wherein the marker band includes at least one axial slit.
[47] The neurovascular catheter of [40] above, wherein the tubular liner is formed by dip coating a removable mandrel.
[48] The neurovascular catheter according to [47] above, wherein the tubular liner contains PTFE.
[49] The neurovascular catheter according to [40], further comprising a binding layer between the inner liner and the helical coil.
[50] The neurovascular catheter of [49] above, wherein the tie layer has a wall thickness of about 0.005 inches or less.
[51] The neurovascular catheter according to [50] above, wherein the binding layer extends along at least the most distal 20 cm of the flexible body.
[52] The neurovascular catheter according to [40] above, wherein the coil contains Nitinol.
[53] The neurovascular catheter according to [52] above, wherein the nitinol is in an austenite state at body temperature.
[54] The neurovascular catheter of [39] above, wherein the outer jacket is formed from at least five axially adjacent discrete tubular sections.
[55] The neurovascular catheter of [54] above, wherein the outer jacket is formed from at least nine axially adjacent discrete tubular sections.
[56] The neurovascular catheter of [54] above, wherein the durometer difference between the proximal one of the tubular section and the distal one of the tubular section is at least about 20D.
[57] The neurovascular catheter of [56] above, wherein the durometer difference between the proximal one of the tubular section and the distal one of the tubular section is at least about 30D.
[58] The neurovascular catheter according to [40] above, further comprising a tension support that increases tension resistance in the distal zone.
[59] The neurovascular catheter with enhanced flexibility according to [58] above, wherein the tension support includes an axially extending filament.
[60] The neurovascular catheter of [59] above, wherein the axially extending filament is supported between the inner liner and the helical coil.
[61] The neurovascular catheter of [59] above, wherein the axially extending filament increases the tensile strength of the tubular body by at least about 2 pounds.
Claims (12)
長手方向軸および遠位ゾーンを含む管状体を含み、前記遠位ゾーンが、
前記管状体の前記長手方向軸に対して約５５度から約６５度までの範囲内の第１角度を形成するカテーテル遠位面と、
内側ライナと、
前記内側ライナを取り囲み、遠位端を含む支持体と；
前記支持体を取り囲み、前記支持体の前記遠位端を越えて遠位に延びて、前記カテーテル遠位面で終端するジャケットと、
前記支持体の前記遠位端と前記カテーテル遠位面との間で前記ジャケット内に埋め込まれた放射線不透過性マーカであって、
前記管状体の前記長手方向軸に対してほぼ垂直な近位面と、
前記管状体の前記長手方向軸に対して約５５度から約６５度までの範囲内の第２角度を形成し、前記カテーテル遠位面にほぼ平行である遠位面と、を含む、放射線不透過性マーカと、
軸方向に延びるフィラメントを含む張力支持体であって、前記軸方向に延びるフィラメントが前記内側ライナと前記支持体との間に支持され、かつ前記内側ライナの周りにらせんを形成する張力支持体と、を含む、神経血管カテーテル。 A neurovascular catheter having an atraumatic navigation tip, the catheter comprising:
a tubular body including a longitudinal axis and a distal zone, the distal zone comprising:
a catheter distal surface forming a first angle within a range of about 55 degrees to about 65 degrees with respect to the longitudinal axis of the tubular body;
an inner liner;
a support surrounding the inner liner and including a distal end;
a jacket surrounding the support and extending distally beyond the distal end of the support and terminating at the distal surface of the catheter;
a radiopaque marker embedded within the jacket between the distal end of the support and the catheter distal surface ;
a proximal surface substantially perpendicular to the longitudinal axis of the tubular body;
a distal surface forming a second angle within a range of about 55 degrees to about 65 degrees with respect to the longitudinal axis of the tubular body and substantially parallel to the catheter distal surface. a transparent marker;
a tension support comprising an axially extending filament, the axially extending filament being supported between the inner liner and the support and forming a helix around the inner liner; , including neurovascular catheters.
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- 2019-04-29 AU AU2019262972A patent/AU2019262972A1/en active Pending
- 2019-04-29 WO PCT/US2019/029709 patent/WO2019212984A1/en unknown
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