JPWO2019200007A5 - - Google Patents
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- JPWO2019200007A5 JPWO2019200007A5 JP2020555033A JP2020555033A JPWO2019200007A5 JP WO2019200007 A5 JPWO2019200007 A5 JP WO2019200007A5 JP 2020555033 A JP2020555033 A JP 2020555033A JP 2020555033 A JP2020555033 A JP 2020555033A JP WO2019200007 A5 JPWO2019200007 A5 JP WO2019200007A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 12
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 7
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 6
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 210000002865 immune cell Anatomy 0.000 claims 6
- -1 OX-40 Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 3
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 3
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 3
- 102100025390 Integrin beta-2 Human genes 0.000 claims 3
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100024263 CD160 antigen Human genes 0.000 claims 2
- 102100038077 CD226 antigen Human genes 0.000 claims 2
- 101710185679 CD276 antigen Proteins 0.000 claims 2
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 2
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 2
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims 2
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 2
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 2
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims 2
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 2
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims 2
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 102100021317 Inducible T-cell costimulator Human genes 0.000 claims 2
- 101710205775 Inducible T-cell costimulator Proteins 0.000 claims 2
- 102100025323 Integrin alpha-1 Human genes 0.000 claims 2
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 2
- 102100022341 Integrin alpha-E Human genes 0.000 claims 2
- 102100022339 Integrin alpha-L Human genes 0.000 claims 2
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 2
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 2
- 102000014128 RANK Ligand Human genes 0.000 claims 2
- 108010025832 RANK Ligand Proteins 0.000 claims 2
- 102100029197 SLAM family member 6 Human genes 0.000 claims 2
- 102100027744 Semaphorin-4D Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- 201000000053 blastoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
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- 201000008184 embryoma Diseases 0.000 claims 2
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 101100350628 Arabidopsis thaliana PLL3 gene Proteins 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 108010056102 CD100 antigen Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100027217 CD82 antigen Human genes 0.000 claims 1
- 101710139831 CD82 antigen Proteins 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 101000585551 Equus caballus Pregnancy-associated glycoprotein Proteins 0.000 claims 1
- 102100022086 GRB2-related adapter protein 2 Human genes 0.000 claims 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims 1
- 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 claims 1
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims 1
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 1
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims 1
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 1
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 1
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 1
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims 1
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims 1
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims 1
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 1
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102100039904 Integrin alpha-D Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 108010041100 Integrin alpha6 Proteins 0.000 claims 1
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 102100033016 Integrin beta-7 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 108091008877 NK cell receptors Proteins 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 1
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 1
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 1
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 1
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 1
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 1
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims 1
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims 1
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims 1
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100029216 SLAM family member 5 Human genes 0.000 claims 1
- 102100029198 SLAM family member 7 Human genes 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102000008115 Signaling Lymphocytic Activation Molecule Family Member 1 Human genes 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 108010065158 Tumor Necrosis Factor Ligand Superfamily Member 14 Proteins 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102100024586 Tumor necrosis factor ligand superfamily member 14 Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 1
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 1
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000000955 neuroendocrine Effects 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862655725P | 2018-04-10 | 2018-04-10 | |
| US62/655,725 | 2018-04-10 | ||
| PCT/US2019/026840 WO2019200007A1 (en) | 2018-04-10 | 2019-04-10 | Chimeric receptors to dll3 and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520788A JP2021520788A (ja) | 2021-08-26 |
| JPWO2019200007A5 true JPWO2019200007A5 (zh) | 2022-04-18 |
| JP7479290B2 JP7479290B2 (ja) | 2024-05-08 |
Family
ID=66248863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555033A Active JP7479290B2 (ja) | 2018-04-10 | 2019-04-10 | Ｄｌｌ３に対するキメラ受容体及びその使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20210163621A1 (zh) |
| EP (1) | EP3773912A1 (zh) |
| JP (1) | JP7479290B2 (zh) |
| KR (1) | KR20210018797A (zh) |
| CN (1) | CN112334193A (zh) |
| AR (1) | AR114283A1 (zh) |
| AU (1) | AU2019251473A1 (zh) |
| BR (1) | BR112020020857A2 (zh) |
| CA (1) | CA3095920A1 (zh) |
| CL (3) | CL2020002613A1 (zh) |
| CO (1) | CO2020013392A2 (zh) |
| CR (1) | CR20200539A (zh) |
| EA (1) | EA202092417A1 (zh) |
| IL (1) | IL277735A (zh) |
| JO (1) | JOP20200259A1 (zh) |
| MA (1) | MA52203A (zh) |
| MX (1) | MX2020010753A (zh) |
| PE (1) | PE20211396A1 (zh) |
| PH (1) | PH12020551671A1 (zh) |
| SG (1) | SG11202009923TA (zh) |
| UY (1) | UY38182A (zh) |
| WO (1) | WO2019200007A1 (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019028316A1 (en) | 2017-08-03 | 2019-02-07 | Amgen Inc. | INTERLEUKIN-21 MUTÉINS AND METHODS OF TREATMENT |
| MX2020007291A (es) | 2018-01-12 | 2020-09-10 | Amgen Inc | Anticuerpos anti-pd-1 y metodos de tratamiento. |
| CA3146019A1 (en) * | 2019-07-17 | 2021-01-21 | Nanjing Legend Biotech Co., Ltd. | Anti-dll3 chimeric antigen receptors and uses thereof |
| US20230272035A1 (en) * | 2019-12-05 | 2023-08-31 | Vycellix, Inc. | Modulators of the immune escape mechanism for universal cell therapy |
| EP4118113A1 (en) | 2020-03-12 | 2023-01-18 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor |
| WO2022206994A1 (en) * | 2021-04-02 | 2022-10-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells and uses thereof |
| CA3214909A1 (en) * | 2021-05-08 | 2022-11-17 | Liuqing Yang | Binding molecule against dll3 and use thereof |
| CA3217141A1 (en) * | 2021-05-10 | 2022-11-17 | Nooshin Hashemi SADRAEI | Dosing regimen for combination therapy targeting dll3 and pd-1 |
| CN117980326A (zh) | 2021-07-14 | 2024-05-03 | 2赛文缇生物公司 | 与来自抗体的结合结构域融合的经工程化的t细胞受体 |
| WO2023166318A2 (en) | 2022-03-03 | 2023-09-07 | Cambridge Enterprise Limited | Therapeutic antibodies |
| WO2023196996A2 (en) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Multipartite receptor and signaling complexes |
| WO2023199069A1 (en) | 2022-04-14 | 2023-10-19 | Crescendo Biologics Limited | Chimeric antigen receptor that binds mesothelin |
| US20240059744A1 (en) * | 2022-07-25 | 2024-02-22 | Interius Biotherapeutics, Inc. | Mutated polypeptides, compositions comprising the same, and uses thereof |
| CN116003628A (zh) * | 2022-08-15 | 2023-04-25 | 南京博安生物技术有限公司 | 靶向人dll3抗原的全人源特异性嵌合抗原受体及其应用 |
| CN116813784B (zh) * | 2023-05-17 | 2024-03-01 | 星奕昂(上海)生物科技有限公司 | 靶向dll3的抗体及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| JP2004500095A (ja) | 2000-02-24 | 2004-01-08 | エクサイト セラピーズ， インコーポレイテッド | 細胞の同時の刺激および濃縮 |
| WO2002036142A2 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| EP3305798A1 (en) | 2010-12-09 | 2018-04-11 | The Trustees of The University of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012103279A2 (en) | 2011-01-26 | 2012-08-02 | Ariad Pharmaceuticals, Incorporated | Methods and compositions for the synthesis of multimerizing agents |
| CN106074601A (zh) | 2011-03-23 | 2016-11-09 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| EP3093294A1 (en) | 2012-02-24 | 2016-11-16 | Stemcentrx, Inc. | Dll3 modulators and methods of use |
| CN105142677B (zh) | 2013-02-15 | 2019-08-30 | 加利福尼亚大学董事会 | 嵌合抗原受体及其使用方法 |
| US9944690B2 (en) | 2013-03-14 | 2018-04-17 | Bellicum Pharmaceuticals, Inc. | Methods for controlling T cell proliferation |
| JP6543626B2 (ja) | 2013-07-29 | 2019-07-10 | ブルーバード バイオ， インコーポレイテッド | 多部分シグナル伝達タンパク質およびその使用 |
| WO2015090229A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Regulatable chimeric antigen receptor |
| JP6772063B2 (ja) | 2014-02-14 | 2020-10-21 | ベリカム ファーマシューティカルズ， インコーポレイテッド | 誘導可能なキメラポリペプチドを使用して細胞を活性化するための方法 |
| MA41613A (fr) * | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究（慕尼黑）公司 | Dll3及cd3抗體構築體 |
| WO2017173410A1 (en) * | 2016-04-01 | 2017-10-05 | Amgen Inc. | Chimeric receptors to flt3 and methods of use thereof |
| CN107400168B (zh) * | 2017-07-18 | 2020-02-07 | 深圳市免疫基因治疗研究院 | 一种基于cd117的嵌合抗原受体及其应用 |
-
2019
- 2019-04-10 UY UY38182A patent/UY38182A/es unknown
- 2019-04-10 MX MX2020010753A patent/MX2020010753A/es unknown
- 2019-04-10 US US17/046,731 patent/US20210163621A1/en active Pending
- 2019-04-10 SG SG11202009923TA patent/SG11202009923TA/en unknown
- 2019-04-10 EA EA202092417A patent/EA202092417A1/ru unknown
- 2019-04-10 CR CR20200539A patent/CR20200539A/es unknown
- 2019-04-10 AU AU2019251473A patent/AU2019251473A1/en active Pending
- 2019-04-10 MA MA052203A patent/MA52203A/fr unknown
- 2019-04-10 BR BR112020020857-4A patent/BR112020020857A2/pt unknown
- 2019-04-10 PE PE2020001573A patent/PE20211396A1/es unknown
- 2019-04-10 CN CN201980025035.1A patent/CN112334193A/zh active Pending
- 2019-04-10 KR KR1020207032081A patent/KR20210018797A/ko unknown
- 2019-04-10 AR ARP190100947A patent/AR114283A1/es unknown
- 2019-04-10 WO PCT/US2019/026840 patent/WO2019200007A1/en unknown
- 2019-04-10 JP JP2020555033A patent/JP7479290B2/ja active Active
- 2019-04-10 CA CA3095920A patent/CA3095920A1/en active Pending
- 2019-04-10 EP EP19719132.3A patent/EP3773912A1/en active Pending
- 2019-04-10 JO JOP/2020/0259A patent/JOP20200259A1/ar unknown
-
2020
- 2020-10-01 IL IL277735A patent/IL277735A/en unknown
- 2020-10-09 CL CL2020002613A patent/CL2020002613A1/es unknown
- 2020-10-09 PH PH12020551671A patent/PH12020551671A1/en unknown
- 2020-10-23 CO CONC2020/0013392A patent/CO2020013392A2/es unknown
-
2023
- 2023-03-28 CL CL2023000896A patent/CL2023000896A1/es unknown
- 2023-03-28 CL CL2023000895A patent/CL2023000895A1/es unknown
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