JPWO2019170731A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2019170731A5
JPWO2019170731A5 JP2020546480A JP2020546480A JPWO2019170731A5 JP WO2019170731 A5 JPWO2019170731 A5 JP WO2019170731A5 JP 2020546480 A JP2020546480 A JP 2020546480A JP 2020546480 A JP2020546480 A JP 2020546480A JP WO2019170731 A5 JPWO2019170731 A5 JP WO2019170731A5
Authority
JP
Japan
Prior art keywords
formula
group
compound
alkyl
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020546480A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021517126A5 (https=
JP2021517126A (ja
JP7417529B2 (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2019/055546 external-priority patent/WO2019170731A1/en
Publication of JP2021517126A publication Critical patent/JP2021517126A/ja
Publication of JP2021517126A5 publication Critical patent/JP2021517126A5/ja
Publication of JPWO2019170731A5 publication Critical patent/JPWO2019170731A5/ja
Application granted granted Critical
Publication of JP7417529B2 publication Critical patent/JP7417529B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020546480A 2018-03-07 2019-03-06 ヌクレオチド前駆体、ヌクレオチド類似体およびこれを含むオリゴマー化合物 Active JP7417529B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18305239 2018-03-07
EP18305239.8 2018-03-07
EP18306497 2018-11-15
EP18306497.1 2018-11-15
PCT/EP2019/055546 WO2019170731A1 (en) 2018-03-07 2019-03-06 Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same

Publications (4)

Publication Number Publication Date
JP2021517126A JP2021517126A (ja) 2021-07-15
JP2021517126A5 JP2021517126A5 (https=) 2022-03-07
JPWO2019170731A5 true JPWO2019170731A5 (https=) 2022-03-07
JP7417529B2 JP7417529B2 (ja) 2024-01-18

Family

ID=65724384

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020546480A Active JP7417529B2 (ja) 2018-03-07 2019-03-06 ヌクレオチド前駆体、ヌクレオチド類似体およびこれを含むオリゴマー化合物

Country Status (5)

Country Link
US (3) US11897911B2 (https=)
EP (1) EP3762395A1 (https=)
JP (1) JP7417529B2 (https=)
CN (1) CN112105625B (https=)
WO (1) WO2019170731A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3762395A1 (en) 2018-03-07 2021-01-13 Sanofi Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
EP3884051A2 (en) 2018-11-23 2021-09-29 Sanofi Novel rna compositions and methods for inhibiting angptl8
US20220290156A1 (en) * 2019-08-27 2022-09-15 Sanofi Compositions and methods for inhibiting pcsk9
JP7667775B2 (ja) * 2019-09-05 2025-04-23 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド
JP2023546103A (ja) * 2020-10-16 2023-11-01 サノフイ Angptl3を阻害するための新規のrna組成物および方法
US20240035029A1 (en) * 2020-10-16 2024-02-01 Sanofi Rna compositions and methods for inhibiting lipoprotein(a)
EP4232455A2 (en) * 2020-10-20 2023-08-30 Sanofi Novel ligands for asialoglycoprotein receptor
CN119320418A (zh) * 2022-01-05 2025-01-17 大睿生物医药科技(上海)有限公司 具有核苷酸类似物的双链rna
WO2024002006A1 (zh) * 2022-06-27 2024-01-04 大睿生物医药科技(上海)有限公司 具有增强的稳定性的核苷酸替代物
EP4559925A1 (en) 2022-07-22 2025-05-28 Sumitomo Chemical Company, Limited Production method of oligonucleotide
JP2025532985A (ja) 2022-09-30 2025-10-03 アルナイラム ファーマシューティカルズ, インコーポレイテッド 修飾二本鎖rna剤
JP2026503499A (ja) * 2023-01-20 2026-01-29 石薬集団中奇制薬技術(石家庄)有限公司 修飾されたヌクレオシド単量体及び二本鎖リボ核酸
CN121358748A (zh) * 2023-06-12 2026-01-16 大睿生物医药科技(上海)有限公司 包含糖的寡核苷酸递送配体
WO2026002117A1 (zh) * 2024-06-26 2026-01-02 上海拓界生物医药科技有限公司 双环结构及包含其的寡核苷酸
WO2026064467A1 (en) * 2024-09-18 2026-03-26 Eli Lilly And Company Improved chemical methods for manufacturing a phosphoramidite used in rna synthesis

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US186174A (en) 1877-01-09 Improvement in rotary churns
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4476301A (en) 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
US5550111A (en) 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US5405938A (en) 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5264423A (en) 1987-03-25 1993-11-23 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5276019A (en) 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US4924624A (en) 1987-10-22 1990-05-15 Temple University-Of The Commonwealth System Of Higher Education 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
US5188897A (en) 1987-10-22 1993-02-23 Temple University Of The Commonwealth System Of Higher Education Encapsulated 2',5'-phosphorothioate oligoadenylates
WO1989009221A1 (en) 1988-03-25 1989-10-05 University Of Virginia Alumni Patents Foundation Oligonucleotide n-alkylphosphoramidates
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5194599A (en) 1988-09-23 1993-03-16 Gilead Sciences, Inc. Hydrogen phosphonodithioate compositions
US5399676A (en) 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US5721218A (en) 1989-10-23 1998-02-24 Gilead Sciences, Inc. Oligonucleotides with inverted polarity
US5264562A (en) 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5177198A (en) 1989-11-30 1993-01-05 University Of N.C. At Chapel Hill Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
US5587361A (en) 1991-10-15 1996-12-24 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5321131A (en) 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
US5665710A (en) 1990-04-30 1997-09-09 Georgetown University Method of making liposomal oligodeoxynucleotide compositions
US5192749A (en) 1990-05-21 1993-03-09 Syntex (U.S.A.) Inc. 4'-substituted nucleosides
US5608046A (en) 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
US5489677A (en) 1990-07-27 1996-02-06 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5618704A (en) 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5541307A (en) 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof
US5677437A (en) 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
ES2083593T3 (es) 1990-08-03 1996-04-16 Sterling Winthrop Inc Compuestos y metodos para inhibir la expresion de genes.
US5177196A (en) 1990-08-16 1993-01-05 Microprobe Corporation Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
US5214134A (en) 1990-09-12 1993-05-25 Sterling Winthrop Inc. Process of linking nucleosides with a siloxane bridge
US5561225A (en) 1990-09-19 1996-10-01 Southern Research Institute Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
CA2092002A1 (en) 1990-09-20 1992-03-21 Mark Matteucci Modified internucleoside linkages
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5672697A (en) 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5571799A (en) 1991-08-12 1996-11-05 Basco, Ltd. (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
EP0642589A4 (en) 1992-05-11 1997-05-21 Ribozyme Pharm Inc METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
US5977343A (en) 1992-05-14 1999-11-02 Ribozyme Pharmaceuticals, Inc. Synthesis, deprotection, analysis and purification of RNA and ribozymes
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
WO1994002595A1 (en) 1992-07-17 1994-02-03 Ribozyme Pharmaceuticals, Inc. Method and reagent for treatment of animal diseases
US5476925A (en) 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
GB9304618D0 (en) 1993-03-06 1993-04-21 Ciba Geigy Ag Chemical compounds
CA2159629A1 (en) 1993-03-31 1994-10-13 Sanofi Oligonucleotides with amide linkages replacing phosphodiester linkages
US5625050A (en) 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5646269A (en) 1994-04-28 1997-07-08 Gilead Sciences, Inc. Method for oligonucleotide analog synthesis
ATE285477T1 (de) 1995-06-07 2005-01-15 Inex Pharmaceutical Corp Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US5981501A (en) 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5889136A (en) 1995-06-09 1999-03-30 The Regents Of The University Of Colorado Orthoester protecting groups in RNA synthesis
US20050032069A1 (en) * 2002-11-05 2005-02-10 Muthiah Manoharan Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US6054576A (en) 1997-10-02 2000-04-25 Ribozyme Pharmaceuticals, Inc. Deprotection of RNA
US6111086A (en) 1998-02-27 2000-08-29 Scaringe; Stephen A. Orthoester protecting groups
AU3751299A (en) 1998-04-20 1999-11-08 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2000003683A2 (en) 1998-07-20 2000-01-27 Inex Pharmaceuticals Corporation Liposomal encapsulated nucleic acid-complexes
US6995259B1 (en) 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
DE60144479D1 (https=) 2000-09-01 2011-06-01 Ribozyme Pharm Inc
WO2002057425A2 (en) 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US6989442B2 (en) 2002-07-12 2006-01-24 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
JP5342881B2 (ja) * 2006-01-27 2013-11-13 アイシス ファーマシューティカルズ, インコーポレーテッド 6−修飾された二環式核酸類似体
US8927513B2 (en) 2009-07-07 2015-01-06 Alnylam Pharmaceuticals, Inc. 5′ phosphate mimics
KR101869570B1 (ko) * 2010-04-28 2018-06-20 아이오니스 파마수티컬즈, 인코포레이티드 변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
BR112016027236A2 (pt) 2014-05-23 2017-10-17 Genzyme Corp porções de múltiplos oligonucleotídeos em veículo de peptídeo
US20160186174A1 (en) 2014-12-29 2016-06-30 Ionis Pharmaceuticals, Inc. Substituted morpholino compounds analogs thereof and oligomeric compounds prepared therefrom
JP2018530587A (ja) * 2015-10-16 2018-10-18 モデルナティエックス インコーポレイテッドModernaTX,Inc. mRNAキャップ類似体およびmRNAキャッピングの方法
IL291323B2 (en) * 2016-07-15 2023-09-01 Am Chemicals Llc Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
EP3762395A1 (en) 2018-03-07 2021-01-13 Sanofi Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
JP7667775B2 (ja) 2019-09-05 2025-04-23 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド

Similar Documents

Publication Publication Date Title
JP2021517126A5 (https=)
JPWO2019170731A5 (https=)
EP2331558B1 (en) Protected monomers and methods of deprotection for rna synthesis
USRE34069E (en) Process for the preparation of oligonucleotides
US6693187B1 (en) Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
US4725677A (en) Process for the preparation of oligonucleotides
CN106795197B (zh) 改性寡核苷酸及其制备方法
EP0751948B1 (en) Novel phosphoramidate and phophorothioamidate oligomeric compounds
JP2761439B2 (ja) リン含有共有結合をつくる方法およびその中間体
JP2013048635A5 (https=)
JPWO2021195533A5 (https=)
US20210179658A1 (en) Orthogonal protecting groups for the preparation of stereodefined phosphorothioate oligonucleotides
JPWO2021070494A5 (https=)
US7022833B2 (en) Process for the preparation of phosphorothioate triesters
US6211350B1 (en) Synthesis of oligonucleotides
JPWO2020235658A5 (https=)
US20070004911A1 (en) Silylated oligonucleotide compounds
US11542294B2 (en) Rapid unylinker cleavage
US20210371450A1 (en) Production method for oligonucleotides
JPWO2020158687A5 (https=)
Hayakawa et al. Nucleotide synthesis via methods without nucleoside-base protection
Sekine et al. Chemical synthesis of oligonucleotides by use of phenylthio group
JPWO2023164464A5 (https=)
JP2022177332A (ja) オリゴヌクレオチドを製造する方法
JP7433684B1 (ja) 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法