JPWO2019147718A5 - - Google Patents

Info

Publication number

JPWO2019147718A5

JPWO2019147718A5 JP2020561591A JP2020561591A JPWO2019147718A5 JP WO2019147718 A5 JPWO2019147718 A5 JP WO2019147718A5 JP 2020561591 A JP2020561591 A JP 2020561591A JP 2020561591 A JP2020561591 A JP 2020561591A JP WO2019147718 A5 JPWO2019147718 A5 JP WO2019147718A5

Authority

JP

Japan

Prior art keywords

glucagon

minutes

therapeutic agent

less

agent according

Prior art date

2022-01-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 101
• 108060003199 Glucagon Proteins 0.000 claims description 55
• 102000051325 Glucagon Human genes 0.000 claims description 53
• 229960004666 glucagon Drugs 0.000 claims description 52
• 239000003814 drug Substances 0.000 claims description 40
• 229940124597 therapeutic agent Drugs 0.000 claims description 40
• 238000000034 method Methods 0.000 claims description 39
• 239000000203 mixture Substances 0.000 claims description 23
• 150000003839 salts Chemical class 0.000 claims description 19
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
• 239000000010 aprotic solvent Substances 0.000 claims description 10
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
• 239000008280 blood Substances 0.000 claims description 8
• 210000004369 blood Anatomy 0.000 claims description 8
• 239000008103 glucose Substances 0.000 claims description 8
• 239000002798 polar solvent Substances 0.000 claims description 8
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
• 239000002253 acid Substances 0.000 claims description 6
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
• 208000013016 Hypoglycemia Diseases 0.000 claims description 4
• 229930195725 Mannitol Natural products 0.000 claims description 4
• 208000008589 Obesity Diseases 0.000 claims description 4
• 239000003125 aqueous solvent Substances 0.000 claims description 4
• 150000001720 carbohydrates Chemical class 0.000 claims description 4
• 235000014633 carbohydrates Nutrition 0.000 claims description 4
• 230000002218 hypoglycaemic effect Effects 0.000 claims description 4
• 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
• 239000000594 mannitol Substances 0.000 claims description 4
• 235000010355 mannitol Nutrition 0.000 claims description 4
• 239000011707 mineral Substances 0.000 claims description 4
• 235000020824 obesity Nutrition 0.000 claims description 4
• 230000000291 postprandial effect Effects 0.000 claims description 4
• 239000003755 preservative agent Substances 0.000 claims description 4
• 230000002335 preservative effect Effects 0.000 claims description 4
• 150000005846 sugar alcohols Chemical class 0.000 claims description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
• 235000019445 benzyl alcohol Nutrition 0.000 claims description 2
• 238000004090 dissolution Methods 0.000 claims description 2
• 238000001802 infusion Methods 0.000 claims description 2
• 235000012054 meals Nutrition 0.000 claims description 2
• 238000012544 monitoring process Methods 0.000 claims description 2
• 239000002904 solvent Substances 0.000 claims description 2
• 208000011580 syndromic disease Diseases 0.000 claims description 2
• 230000002980 postoperative effect Effects 0.000 claims 1
• 125000000647 trehalose group Chemical group 0.000 claims 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1