JPWO2019118788A5 - - Google Patents
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- Publication number
- JPWO2019118788A5 JPWO2019118788A5 JP2020551783A JP2020551783A JPWO2019118788A5 JP WO2019118788 A5 JPWO2019118788 A5 JP WO2019118788A5 JP 2020551783 A JP2020551783 A JP 2020551783A JP 2020551783 A JP2020551783 A JP 2020551783A JP WO2019118788 A5 JPWO2019118788 A5 JP WO2019118788A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- juice
- magnesium
- polysaccharide
- treatment composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000284 extract Substances 0.000 claims 33
- 229920001282 polysaccharide Polymers 0.000 claims 29
- 239000005017 polysaccharide Substances 0.000 claims 29
- -1 Sulfate polysaccharides Chemical class 0.000 claims 18
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 14
- 239000003963 antioxidant agent Substances 0.000 claims 13
- 239000006186 oral dosage form Substances 0.000 claims 12
- 150000004676 glycans Chemical class 0.000 claims 11
- 230000003078 antioxidant effect Effects 0.000 claims 10
- 239000011777 magnesium Substances 0.000 claims 10
- 229910052749 magnesium Inorganic materials 0.000 claims 10
- 229940091250 magnesium supplement Drugs 0.000 claims 10
- 241000195493 Cryptophyta Species 0.000 claims 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 9
- 241000196324 Embryophyta Species 0.000 claims 8
- 239000000843 powder Substances 0.000 claims 8
- 229910021653 sulphate ion Inorganic materials 0.000 claims 7
- 241000989762 Monostroma nitidum Species 0.000 claims 5
- 241001593968 Vitis palmata Species 0.000 claims 5
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- 244000196998 Pilea microphylla Species 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- 229940087603 grape seed extract Drugs 0.000 claims 4
- 235000002532 grape seed extract Nutrition 0.000 claims 4
- 235000013761 grape skin extract Nutrition 0.000 claims 4
- 239000001717 vitis vinifera seed extract Substances 0.000 claims 4
- 241001474374 Blennius Species 0.000 claims 3
- 241000206575 Chondrus crispus Species 0.000 claims 3
- 241001512722 Ecklonia cava Species 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 241001428138 Grateloupia Species 0.000 claims 3
- 241000196251 Ulva arasakii Species 0.000 claims 3
- 241000219095 Vitis Species 0.000 claims 3
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 3
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000234282 Allium Species 0.000 claims 2
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims 2
- 240000002234 Allium sativum Species 0.000 claims 2
- 244000003416 Asparagus officinalis Species 0.000 claims 2
- 235000005340 Asparagus officinalis Nutrition 0.000 claims 2
- 240000007124 Brassica oleracea Species 0.000 claims 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 2
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims 2
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 2
- 229910002651 NO3 Inorganic materials 0.000 claims 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 2
- 240000007817 Olea europaea Species 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 235000015190 carrot juice Nutrition 0.000 claims 2
- 235000020379 cucumber juice Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 235000004611 garlic Nutrition 0.000 claims 2
- 235000001055 magnesium Nutrition 0.000 claims 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 2
- 239000001095 magnesium carbonate Substances 0.000 claims 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 2
- 229960001708 magnesium carbonate Drugs 0.000 claims 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 229960002337 magnesium chloride Drugs 0.000 claims 2
- 235000011147 magnesium chloride Nutrition 0.000 claims 2
- 229960005336 magnesium citrate Drugs 0.000 claims 2
- 235000002538 magnesium citrate Nutrition 0.000 claims 2
- 239000004337 magnesium citrate Substances 0.000 claims 2
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims 2
- 239000000626 magnesium lactate Substances 0.000 claims 2
- 229960004658 magnesium lactate Drugs 0.000 claims 2
- 235000015229 magnesium lactate Nutrition 0.000 claims 2
- JFQQIWNDAXACSR-UHFFFAOYSA-L magnesium malate Chemical compound [Mg+2].[O-]C(=O)C(O)CC([O-])=O JFQQIWNDAXACSR-UHFFFAOYSA-L 0.000 claims 2
- 229940096424 magnesium malate Drugs 0.000 claims 2
- QWLHYYKDLOVBNV-UHFFFAOYSA-L magnesium orotate Chemical compound [Mg+2].[O-]C(=O)C1=CC(=O)NC(=O)N1.[O-]C(=O)C1=CC(=O)NC(=O)N1 QWLHYYKDLOVBNV-UHFFFAOYSA-L 0.000 claims 2
- 229960000407 magnesium orotate Drugs 0.000 claims 2
- 239000000395 magnesium oxide Substances 0.000 claims 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 2
- 229960000869 magnesium oxide Drugs 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 229960003390 magnesium sulfate Drugs 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- YZURQOBSFRVSEB-UHFFFAOYSA-L magnesium;2-aminoethanesulfonate Chemical compound [Mg+2].NCCS([O-])(=O)=O.NCCS([O-])(=O)=O YZURQOBSFRVSEB-UHFFFAOYSA-L 0.000 claims 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical group [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims 2
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 claims 2
- 239000002893 slag Substances 0.000 claims 2
- 235000015193 tomato juice Nutrition 0.000 claims 2
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 235000019143 vitamin K2 Nutrition 0.000 claims 2
- 239000011728 vitamin K2 Substances 0.000 claims 2
- 240000006432 Carica papaya Species 0.000 claims 1
- 235000009467 Carica papaya Nutrition 0.000 claims 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 244000018633 Prunus armeniaca Species 0.000 claims 1
- 235000009827 Prunus armeniaca Nutrition 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 claims 1
- 244000078534 Vaccinium myrtillus Species 0.000 claims 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000002583 angiography Methods 0.000 claims 1
- 235000015197 apple juice Nutrition 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 235000015120 cherry juice Nutrition 0.000 claims 1
- 238000002591 computed tomography Methods 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 235000015201 grapefruit juice Nutrition 0.000 claims 1
- 235000009569 green tea Nutrition 0.000 claims 1
- 229940094952 green tea extract Drugs 0.000 claims 1
- 235000020688 green tea extract Nutrition 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002608 intravascular ultrasound Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 235000013997 pineapple juice Nutrition 0.000 claims 1
- 235000019675 red grape juice Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 208000037804 stenosis Diseases 0.000 claims 1
- 235000013948 strawberry juice Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- 238000012285 ultrasound imaging Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762598839P | 2017-12-14 | 2017-12-14 | |
| US62/598,839 | 2017-12-14 | ||
| US201862676185P | 2018-05-24 | 2018-05-24 | |
| US62/676,185 | 2018-05-24 | ||
| PCT/US2018/065562 WO2019118788A1 (en) | 2017-12-14 | 2018-12-13 | Methods to stabilize and reverse atherosclerotic lesions by sulfated polysaccharides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021510170A JP2021510170A (ja) | 2021-04-15 |
| JPWO2019118788A5 true JPWO2019118788A5 (zh) | 2022-05-12 |
| JP7384817B2 JP7384817B2 (ja) | 2023-11-21 |
Family
ID=66820710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551783A Active JP7384817B2 (ja) | 2017-12-14 | 2018-12-13 | アテローム性動脈硬化病変を硫酸多糖で安定化及び改善する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11135238B2 (zh) |
| EP (1) | EP3724236A4 (zh) |
| JP (1) | JP7384817B2 (zh) |
| KR (1) | KR20200110328A (zh) |
| CN (2) | CN115778980A (zh) |
| AU (1) | AU2018383677B2 (zh) |
| BR (1) | BR112020012025A2 (zh) |
| CA (1) | CA3085749A1 (zh) |
| WO (1) | WO2019118788A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110467686B (zh) * | 2019-09-17 | 2021-03-30 | 齐鲁工业大学 | 一种芦笋根多糖的高效提取方法 |
| CN113069129B (zh) * | 2021-02-26 | 2023-04-11 | 四川省肿瘤医院 | 一种18f-fdg pet/ct检查去除胃内伪影的方法 |
| CN113559114B (zh) * | 2021-09-26 | 2022-01-18 | 汇泰渤海水产有限责任公司 | 浒苔多糖在降低泡沫细胞脂质堆积中的应用 |
| CN115651087A (zh) * | 2022-08-11 | 2023-01-31 | 广东海洋大学 | 纳米硒浒苔多糖的制备方法及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998046588A2 (en) * | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| ITMI20010779A1 (it) * | 2001-04-12 | 2002-10-12 | Giorgio Zoppetti | Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi |
| US20040097466A1 (en) | 2002-11-19 | 2004-05-20 | Bruce Daniels | Treatment of a patient suffering from cell surface thrombosis disorders using enhanced absorption of arginine |
| US20040208893A1 (en) | 2002-12-16 | 2004-10-21 | Daniels Bruce Alan | Seaweed extract composition for treatment of diabetes and diabetic complications |
| US6797705B2 (en) | 2002-12-16 | 2004-09-28 | Endomatrix, Inc. | Rhamnan sulphate composition for treatment of endothelial dysfunction |
| JP2007516225A (ja) * | 2003-05-14 | 2007-06-21 | エンドゥマトリクス，インコーポレイテッド | 糖尿病および糖尿病合併症の治療のための海藻組成物 |
| US7214383B2 (en) | 2003-06-16 | 2007-05-08 | Bruce Alan Daniels | Stent for delivery of drugs to the endothelium |
| US20050196410A1 (en) | 2004-03-05 | 2005-09-08 | Daniels Bruce A. | Seaweed extract composition for treatment of inflammation |
| US20070036821A1 (en) | 2004-03-05 | 2007-02-15 | Daniels Bruce A | Seaweed extract composition for retardation of cardiovascular disorders and preservation of healthy cardiovascular function |
| DK1728507T4 (en) | 2005-06-03 | 2015-01-12 | Nattopharma Asa | The use of vitamin K to reverse calcification of the blood vessel |
| WO2007088554A1 (en) * | 2006-01-31 | 2007-08-09 | Baskaran Chandrasekar | A pharmaceutical composition for treatment of vulnerable atherosclerotic plaque and inhibition of thrombosis, adhesion molecules and inflammation |
| US20140046052A1 (en) | 2011-09-21 | 2014-02-13 | Bruce A. Daniels | Therapeutic Sulfated Polysaccharides, Compositions Thereof, and Methods for Treating Patients |
| US20130273096A1 (en) * | 2011-10-05 | 2013-10-17 | Bruce A. Daniels | Therapeutic Sulfated Polysaccharides, Compositions Thereof, and Methods for Treating Patients |
| US9554727B2 (en) | 2013-08-19 | 2017-01-31 | Cedars-Sinai Medical Center | Atherosclerosis characterization using a multi-contrast MRI sequence |
| KR101972691B1 (ko) * | 2015-04-08 | 2019-04-25 | 마이크로바스쿨라 헬스 솔루션즈, 엘엘씨 | 상승적인 글리코칼릭스 치료 조성물 및 방법 |
-
2018
- 2018-12-13 JP JP2020551783A patent/JP7384817B2/ja active Active
- 2018-12-13 US US16/219,854 patent/US11135238B2/en active Active
- 2018-12-13 CA CA3085749A patent/CA3085749A1/en active Pending
- 2018-12-13 KR KR1020207020253A patent/KR20200110328A/ko not_active Application Discontinuation
- 2018-12-13 EP EP18889047.9A patent/EP3724236A4/en active Pending
- 2018-12-13 CN CN202310026869.2A patent/CN115778980A/zh active Pending
- 2018-12-13 WO PCT/US2018/065562 patent/WO2019118788A1/en unknown
- 2018-12-13 CN CN201880088822.6A patent/CN111836833B/zh active Active
- 2018-12-13 BR BR112020012025-1A patent/BR112020012025A2/pt unknown
- 2018-12-13 AU AU2018383677A patent/AU2018383677B2/en active Active
-
2021
- 2021-10-05 US US17/494,281 patent/US20220249537A1/en active Pending
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