JPWO2018200656A5 - - Google Patents
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- Publication number
- JPWO2018200656A5 JPWO2018200656A5 JP2019557833A JP2019557833A JPWO2018200656A5 JP WO2018200656 A5 JPWO2018200656 A5 JP WO2018200656A5 JP 2019557833 A JP2019557833 A JP 2019557833A JP 2019557833 A JP2019557833 A JP 2019557833A JP WO2018200656 A5 JPWO2018200656 A5 JP WO2018200656A5
- Authority
- JP
- Japan
- Prior art keywords
- adjuvant
- hemolytic
- activity
- resulting
- present application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002671 adjuvant Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000002949 hemolytic effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762489572P | 2017-04-25 | 2017-04-25 | |
| US62/489,572 | 2017-04-25 | ||
| US201762492608P | 2017-05-01 | 2017-05-01 | |
| US62/492,608 | 2017-05-01 | ||
| PCT/US2018/029333 WO2018200656A1 (en) | 2017-04-25 | 2018-04-25 | Triterpene saponin analogues |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020517686A JP2020517686A (ja) | 2020-06-18 |
| JP2020517686A5 JP2020517686A5 (enExample) | 2021-11-18 |
| JPWO2018200656A5 true JPWO2018200656A5 (enExample) | 2022-07-20 |
| JP7177082B2 JP7177082B2 (ja) | 2022-11-22 |
Family
ID=63918684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557833A Active JP7177082B2 (ja) | 2017-04-25 | 2018-04-25 | トリテルペンサポニン類似物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200164065A1 (enExample) |
| EP (1) | EP3615039A4 (enExample) |
| JP (1) | JP7177082B2 (enExample) |
| CN (1) | CN110730666A (enExample) |
| WO (1) | WO2018200656A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016349693B2 (en) | 2015-11-06 | 2022-08-11 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| CA3075822A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| CN114630671A (zh) * | 2019-11-05 | 2022-06-14 | 佐剂技术公司 | 水痘带状疱疹 |
| US20230128815A1 (en) * | 2020-03-23 | 2023-04-27 | Adjuvance Technologies, Inc. | Adjuvant compounds, salt forms, and formulations |
| AU2021276401A1 (en) | 2020-05-19 | 2022-12-15 | Othair Prothena Limited | Multi-epitope vaccine for the treatment of Alzheimer's disease |
| KR20230080397A (ko) | 2020-08-07 | 2023-06-07 | 오타이르 프로테나 리미티드 | 알츠하이머 질환을 치료하기 위한 멀티에피토프 백신 |
| WO2022221393A1 (en) * | 2021-04-14 | 2022-10-20 | Adjuvance Technologies, Inc. | Vaccines |
| EP4429674A4 (en) * | 2021-11-08 | 2025-10-08 | Adjuvance Tech Inc | ADJUVANT COMPOUNDS AND FORMULATIONS |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| US20250114448A1 (en) | 2022-01-19 | 2025-04-10 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
| CN117106004A (zh) * | 2022-05-17 | 2023-11-24 | 北京科兴中维生物技术有限公司 | 三萜皂苷化合物及其制备方法及应用 |
| WO2024218268A1 (en) | 2023-04-20 | 2024-10-24 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin derivatives as adjuvants and photoaffinity probes |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504436D0 (en) * | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| BRPI0822098A2 (pt) * | 2007-12-21 | 2015-06-30 | Glaxosmithkline Biolog Sa | Componente para uma vacina contra malária, vacina para malária, processo para a preparação do componente, uso do componente, e, método de tratar um paciente suscetível às infecções por plasmodium |
| KR102453184B1 (ko) * | 2008-04-08 | 2022-10-07 | 슬로안-케테링인스티튜트퍼캔서리서치 | 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 |
| WO2009127676A1 (en) * | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
| IL290897B2 (en) | 2014-05-30 | 2023-10-01 | Memorial Sloan Kettering Cancer Center | Minimal saponin analogues, their synthesis and use |
| AU2016349693B2 (en) | 2015-11-06 | 2022-08-11 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
-
2018
- 2018-04-25 CN CN201880027709.7A patent/CN110730666A/zh active Pending
- 2018-04-25 WO PCT/US2018/029333 patent/WO2018200656A1/en not_active Ceased
- 2018-04-25 US US16/608,352 patent/US20200164065A1/en not_active Abandoned
- 2018-04-25 EP EP18791346.2A patent/EP3615039A4/en not_active Withdrawn
- 2018-04-25 JP JP2019557833A patent/JP7177082B2/ja active Active
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