JPWO2017214726A5 - - Google Patents
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- Publication number
- JPWO2017214726A5 JPWO2017214726A5 JP2018566415A JP2018566415A JPWO2017214726A5 JP WO2017214726 A5 JPWO2017214726 A5 JP WO2017214726A5 JP 2018566415 A JP2018566415 A JP 2018566415A JP 2018566415 A JP2018566415 A JP 2018566415A JP WO2017214726 A5 JPWO2017214726 A5 JP WO2017214726A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- gene silencing
- expression
- sirna
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004055 small Interfering RNA Substances 0.000 description 6
- 108020004459 Small interfering RNA Proteins 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 230000030279 gene silencing Effects 0.000 description 5
- 238000012226 gene silencing method Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 3
- 239000000074 antisense oligonucleotide Substances 0.000 description 3
- 238000012230 antisense oligonucleotides Methods 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108700011259 MicroRNAs Proteins 0.000 description 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
- 108091027967 Small hairpin RNA Proteins 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- 241001635598 Enicostema Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 101710203526 Integrase Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000032361 posttranscriptional gene silencing Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107289A JP2023123748A (ja) | 2016-06-14 | 2023-06-29 | 転移性癌の診断及び治療の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2932910A CA2932910A1 (en) | 2016-06-14 | 2016-06-14 | Methods for diagnosing and treating metastatic cancer |
| CA2,932,910 | 2016-06-14 | ||
| PCT/CA2017/050729 WO2017214726A1 (en) | 2016-06-14 | 2017-06-14 | Methods for diagnosing and treating metastatic cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107289A Division JP2023123748A (ja) | 2016-06-14 | 2023-06-29 | 転移性癌の診断及び治療の方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019525903A JP2019525903A (ja) | 2019-09-12 |
| JPWO2017214726A5 true JPWO2017214726A5 (https=) | 2023-06-02 |
| JP2019525903A5 JP2019525903A5 (https=) | 2023-06-02 |
| JP7306829B2 JP7306829B2 (ja) | 2023-07-11 |
Family
ID=60655897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566415A Active JP7306829B2 (ja) | 2016-06-14 | 2017-06-14 | 転移性癌の診断及び治療の方法 |
| JP2023107289A Pending JP2023123748A (ja) | 2016-06-14 | 2023-06-29 | 転移性癌の診断及び治療の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107289A Pending JP2023123748A (ja) | 2016-06-14 | 2023-06-29 | 転移性癌の診断及び治療の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11236331B2 (https=) |
| EP (1) | EP3468564A4 (https=) |
| JP (2) | JP7306829B2 (https=) |
| CN (1) | CN109562121A (https=) |
| AU (2) | AU2017285726B2 (https=) |
| CA (2) | CA2932910A1 (https=) |
| MX (2) | MX2018015474A (https=) |
| WO (1) | WO2017214726A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11304988B2 (en) * | 2018-01-24 | 2022-04-19 | Northwestern University | Inhibiting tumor cell migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) |
| US20210251963A1 (en) * | 2018-09-06 | 2021-08-19 | Scandion Oncology A/S | Urea derivatives for use in the treatment of subjects with elevated expression and/or activity of srpk1 |
| CN117187375B (zh) * | 2023-09-12 | 2024-06-18 | 上海谱希和光基因科技有限公司 | Kdelr3生物标志物在诊断高度近视中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US6040166A (en) | 1985-03-28 | 2000-03-21 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences, including a probe |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DE3938907C2 (de) | 1989-11-24 | 1999-11-04 | Dade Behring Marburg Gmbh | Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten |
| FR2814349B1 (fr) | 2000-09-27 | 2002-12-06 | Salomon Sa | Sac a dos |
| KR101446626B1 (ko) | 2005-09-02 | 2014-10-06 | 도레이 카부시키가이샤 | 신장암 진단, 신장암 환자 예후 예측을 위한 조성물 및 방법 |
| CN101300348A (zh) | 2005-09-02 | 2008-11-05 | 东丽株式会社 | 肾癌诊断、肾癌患者预后预测用的组合物及方法 |
| WO2007056604A2 (en) | 2005-11-09 | 2007-05-18 | Irm Llc | Methods and compositions for modulating cell motility and inhibiting tumor metastasis |
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| WO2013098797A2 (en) * | 2011-12-31 | 2013-07-04 | Kuriakose Moni Abraham | Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer |
| US20160025728A1 (en) | 2013-03-15 | 2016-01-28 | Board Of Regents, The University Of Texas System | Brain-specific gene signature of tumor cells |
| JP6663149B2 (ja) | 2014-07-04 | 2020-03-11 | 国立大学法人高知大学 | 膵がん細胞浸潤転移阻害剤 |
-
2016
- 2016-06-14 CA CA2932910A patent/CA2932910A1/en not_active Abandoned
-
2017
- 2017-06-14 AU AU2017285726A patent/AU2017285726B2/en active Active
- 2017-06-14 US US16/309,800 patent/US11236331B2/en active Active
- 2017-06-14 JP JP2018566415A patent/JP7306829B2/ja active Active
- 2017-06-14 CA CA3027430A patent/CA3027430A1/en active Pending
- 2017-06-14 WO PCT/CA2017/050729 patent/WO2017214726A1/en not_active Ceased
- 2017-06-14 EP EP17812358.4A patent/EP3468564A4/en active Pending
- 2017-06-14 MX MX2018015474A patent/MX2018015474A/es unknown
- 2017-06-14 CN CN201780045853.9A patent/CN109562121A/zh active Pending
-
2018
- 2018-12-13 MX MX2022012073A patent/MX2022012073A/es unknown
-
2021
- 2021-12-22 US US17/558,705 patent/US12421514B2/en active Active
-
2023
- 2023-06-15 AU AU2023203737A patent/AU2023203737B2/en active Active
- 2023-06-29 JP JP2023107289A patent/JP2023123748A/ja active Pending
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