CN109562121A - 转移性癌症的诊断和治疗方法 - Google Patents

转移性癌症的诊断和治疗方法 Download PDF

Info

Publication number
CN109562121A
CN109562121A CN201780045853.9A CN201780045853A CN109562121A CN 109562121 A CN109562121 A CN 109562121A CN 201780045853 A CN201780045853 A CN 201780045853A CN 109562121 A CN109562121 A CN 109562121A
Authority
CN
China
Prior art keywords
mirna
inhibitor
kif3b
nr2f1
srpk1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780045853.9A
Other languages
English (en)
Chinese (zh)
Inventor
J·路易斯
K·斯多列托夫
L·威利茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Entos Pharmaceuticals Inc
Original Assignee
Entos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entos Pharmaceuticals Inc filed Critical Entos Pharmaceuticals Inc
Publication of CN109562121A publication Critical patent/CN109562121A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780045853.9A 2016-06-14 2017-06-14 转移性癌症的诊断和治疗方法 Pending CN109562121A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2932910A CA2932910A1 (en) 2016-06-14 2016-06-14 Methods for diagnosing and treating metastatic cancer
CA2,932,910 2016-06-14
PCT/CA2017/050729 WO2017214726A1 (en) 2016-06-14 2017-06-14 Methods for diagnosing and treating metastatic cancer

Publications (1)

Publication Number Publication Date
CN109562121A true CN109562121A (zh) 2019-04-02

Family

ID=60655897

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780045853.9A Pending CN109562121A (zh) 2016-06-14 2017-06-14 转移性癌症的诊断和治疗方法

Country Status (8)

Country Link
US (2) US11236331B2 (https=)
EP (1) EP3468564A4 (https=)
JP (2) JP7306829B2 (https=)
CN (1) CN109562121A (https=)
AU (2) AU2017285726B2 (https=)
CA (2) CA2932910A1 (https=)
MX (2) MX2018015474A (https=)
WO (1) WO2017214726A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11304988B2 (en) * 2018-01-24 2022-04-19 Northwestern University Inhibiting tumor cell migration by inhibition of kinesin light chain 1, variant 1 (KLC1C)
US20210251963A1 (en) * 2018-09-06 2021-08-19 Scandion Oncology A/S Urea derivatives for use in the treatment of subjects with elevated expression and/or activity of srpk1
CN117187375B (zh) * 2023-09-12 2024-06-18 上海谱希和光基因科技有限公司 Kdelr3生物标志物在诊断高度近视中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101300348A (zh) * 2005-09-02 2008-11-05 东丽株式会社 肾癌诊断、肾癌患者预后预测用的组合物及方法
CN102388062A (zh) * 2007-12-17 2012-03-21 私人基金基因组调控中心(Crg) 用于治疗癌症的trail变体
WO2013098797A2 (en) * 2011-12-31 2013-07-04 Kuriakose Moni Abraham Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
DE3938907C2 (de) 1989-11-24 1999-11-04 Dade Behring Marburg Gmbh Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten
FR2814349B1 (fr) 2000-09-27 2002-12-06 Salomon Sa Sac a dos
KR101446626B1 (ko) 2005-09-02 2014-10-06 도레이 카부시키가이샤 신장암 진단, 신장암 환자 예후 예측을 위한 조성물 및 방법
WO2007056604A2 (en) 2005-11-09 2007-05-18 Irm Llc Methods and compositions for modulating cell motility and inhibiting tumor metastasis
US20160025728A1 (en) 2013-03-15 2016-01-28 Board Of Regents, The University Of Texas System Brain-specific gene signature of tumor cells
JP6663149B2 (ja) 2014-07-04 2020-03-11 国立大学法人高知大学 膵がん細胞浸潤転移阻害剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101300348A (zh) * 2005-09-02 2008-11-05 东丽株式会社 肾癌诊断、肾癌患者预后预测用的组合物及方法
CN102388062A (zh) * 2007-12-17 2012-03-21 私人基金基因组调控中心(Crg) 用于治疗癌症的trail变体
WO2013098797A2 (en) * 2011-12-31 2013-07-04 Kuriakose Moni Abraham Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIAODONG HUANG ET AL: "Suppression of KIF3B Expression Inhibits Human Hepatocellular Carcinoma Proliferation", 《DIG DIS SCI》 *

Also Published As

Publication number Publication date
WO2017214726A1 (en) 2017-12-21
JP7306829B2 (ja) 2023-07-11
JP2023123748A (ja) 2023-09-05
AU2017285726A1 (en) 2019-01-24
US11236331B2 (en) 2022-02-01
US12421514B2 (en) 2025-09-23
EP3468564A4 (en) 2020-07-29
AU2023203737B2 (en) 2024-08-29
CA2932910A1 (en) 2017-12-14
MX2018015474A (es) 2019-06-06
US20190177727A1 (en) 2019-06-13
EP3468564A1 (en) 2019-04-17
JP2019525903A (ja) 2019-09-12
AU2017285726B2 (en) 2023-03-16
CA3027430A1 (en) 2017-12-21
US20220112498A1 (en) 2022-04-14
AU2023203737A1 (en) 2023-07-06
MX2022012073A (es) 2022-10-18

Similar Documents

Publication Publication Date Title
Liu et al. Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation
WO2014017491A1 (ja) Ｃｅｐ５５遺伝子とｒｅｔ遺伝子との融合遺伝子
Ramirez et al. Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
AU2023203737B2 (en) Methods for diagnosing and treating metastatic cancer
Okita et al. Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene
Liao et al. USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4.
JP2022060484A (ja) 悪性リンパ腫又は白血病の罹患の有無の判別方法並びに白血病の治療及び／又は予防のための薬剤
CN112867495A (zh) 包含syt11抑制剂作为活性成分的胃癌治疗组合物
CN115837079A (zh) Igf2bp1高表达在食管癌检测和治疗中的应用
Jin et al. Assessment of a novel VEGF targeted agent using patient-derived tumor tissue xenograft models of colon carcinoma with lymphatic and hepatic metastases
CN111187835A (zh) 胰腺癌的靶点erbb2及其在诊断和治疗中的应用
WO2008038832A1 (en) Therapeutic agent, detection method and detection kit for breast cancer and ovarian cancer
TW201204393A (en) Diagnostic agent and therapeutic agent of cancer
CN114908162B (zh) Rrm2在晚期胃肠间质瘤的诊断和治疗中的应用
CN111424092B (zh) 一种检测基因及其应用
JP7510144B2 (ja) 抗癌剤及びその使用
Zhu et al. circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein
Batra et al. Reviewing oncogenes and proto-oncogenes
Chen et al. Tumor suppressor miR-449a inhibits the development of gastric cancer via down-regulation of SGPL1
CN116829953A (zh) 确定对检查点抑制剂疗法的抗性的方法
Shao et al. Upregulation of has_circ_0008389 promotes esophageal squamous cell carcinoma progression via miR-761 sponging and P2RY2 mRNA stabilization
JP2018164442A (ja) 皮膚有棘細胞癌の判定、予防又は治療方法
Ramnarayanan Dissecting the Heterogeneity of Gastric Cancer at the Single Cell Level
CN119061144A (zh) 肿瘤标志物在肝癌预后、严重程度评估及肝癌治疗中的应用
CN115068614A (zh) 用于诊断、治疗和预防癌症的方法和组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20190402