JPWO2003106429A1 - プロドラッグおよびその製造法 - Google Patents
プロドラッグおよびその製造法 Download PDFInfo
- Publication number
- JPWO2003106429A1 JPWO2003106429A1 JP2004513262A JP2004513262A JPWO2003106429A1 JP WO2003106429 A1 JPWO2003106429 A1 JP WO2003106429A1 JP 2004513262 A JP2004513262 A JP 2004513262A JP 2004513262 A JP2004513262 A JP 2004513262A JP WO2003106429 A1 JPWO2003106429 A1 JP WO2003106429A1
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituent
- compound
- atom
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*OC(OC)=N Chemical compound C*OC(OC)=N 0.000 description 1
- YUZJGVMVVMOXOS-UHFFFAOYSA-N CCOC(OCCNC)=O Chemical compound CCOC(OCCNC)=O YUZJGVMVVMOXOS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002175086 | 2002-06-14 | ||
| JP2002175086 | 2002-06-14 | ||
| JP2003041085 | 2003-02-19 | ||
| JP2003041085 | 2003-02-19 | ||
| PCT/JP2003/007545 WO2003106429A1 (fr) | 2002-06-14 | 2003-06-13 | Promedicament et procede de production de celui-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2003106429A1 true JPWO2003106429A1 (ja) | 2005-10-13 |
Family
ID=29738411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513262A Pending JPWO2003106429A1 (ja) | 2002-06-14 | 2003-06-13 | プロドラッグおよびその製造法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7410981B2 (fr) |
| EP (2) | EP1513527B1 (fr) |
| JP (1) | JPWO2003106429A1 (fr) |
| KR (1) | KR20050009751A (fr) |
| CN (1) | CN1678315A (fr) |
| AR (1) | AR040221A1 (fr) |
| AT (1) | ATE437642T1 (fr) |
| AU (2) | AU2003242388A1 (fr) |
| BR (1) | BR0311801A (fr) |
| CA (2) | CA2489470A1 (fr) |
| DE (1) | DE60328603D1 (fr) |
| IL (1) | IL165562A0 (fr) |
| MX (1) | MXPA04012396A (fr) |
| NO (1) | NO20050141L (fr) |
| OA (1) | OA12867A (fr) |
| PE (1) | PE20040563A1 (fr) |
| PL (1) | PL373085A1 (fr) |
| TW (1) | TW200307544A (fr) |
| WO (2) | WO2003106429A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176319B2 (en) | 2004-04-28 | 2007-02-13 | Hetero Drugs Limited | Process for substituted sulfoxides |
| EP2275088B2 (fr) | 2005-02-25 | 2018-09-26 | Takeda Pharmaceutical Company Limited | Procédé de fabrication de granulés |
| KR101148399B1 (ko) * | 2005-06-22 | 2012-05-23 | 일양약품주식회사 | 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물 |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| US20080103169A1 (en) | 2006-10-27 | 2008-05-01 | The Curators Of The University Of Missouri | Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same |
| WO2009105568A1 (fr) | 2008-02-20 | 2009-08-27 | The Curators Of The University Of Missouri | Composition comprenant une combinaison d'oméprazole et de lansoprazole, et un agent tampon, et ses méthodes d'utilisation |
| CA2778115C (fr) | 2009-10-28 | 2016-04-05 | Newlink Genetics Corporation | Derives imidazole comme inhibiteurs de l'ido |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| WO2016172436A1 (fr) * | 2015-04-23 | 2016-10-27 | Temple University-Of The Commonwealth System Of Higher Education | Composés amphiphiles polycationiques et leurs polymères utilisables en tant qu'agents antimicrobiens et leurs procédés d'utilisation |
| ES2836500T3 (es) * | 2016-06-21 | 2021-06-25 | Univ Columbia | Inhibidores de aldosa reductasa y métodos de uso de los mismos |
| WO2018081347A1 (fr) | 2016-10-26 | 2018-05-03 | Temple University-Of The Commonwealth System Of Higher Education | Composés amphiphiles polycationiques utiles en tant qu'agents antimicrobiens et leurs méthodes d'utilisation |
| MX2020001057A (es) | 2017-07-28 | 2020-11-24 | Applied Therapeutics Inc | Composiciones y metodos para tratar la galactosemia. |
| US11767311B2 (en) * | 2020-06-17 | 2023-09-26 | Ildong Pharmaceutical Co., Ltd. | Acid secretion inhibitor and use thereof |
| IT202200001022A1 (it) * | 2022-01-21 | 2023-07-21 | Exo Lab Italia | Composti farmaceutici ibridi ottenuti mediante coniugazione di un inibitore delle pompe protoniche e un inibitore delle anidrasi carboniche |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| KR890000387B1 (ko) | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| US4965269A (en) | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| DE19832060C2 (de) * | 1998-07-16 | 2000-07-06 | Siemens Ag | Doppelbare Prozessoreinrichtung |
| US6542966B1 (en) * | 1998-07-16 | 2003-04-01 | Intel Corporation | Method and apparatus for managing temporal and non-temporal data in a single cache structure |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| HUP0202431A3 (en) * | 1999-04-09 | 2003-03-28 | Basf Ag | Prodrugs of thrombin inhibitors |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| EP1334104A2 (fr) * | 2000-07-07 | 2003-08-13 | Neotherapeutics, Inc. | Procedes de traitement de neuropathie peripherique induite par des medicaments et etats associes |
| EP1334971A4 (fr) | 2000-10-12 | 2004-05-12 | Takeda Chemical Industries Ltd | Composes derives de benzimidazole, leur procede de production et leur utilisation |
| US7129261B2 (en) * | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
| US20040248941A1 (en) | 2001-09-25 | 2004-12-09 | Keiji Kamiyama | Benzimidazone compound, process for producing the same, and use thereof |
-
2003
- 2003-06-13 DE DE60328603T patent/DE60328603D1/de not_active Expired - Lifetime
- 2003-06-13 AU AU2003242388A patent/AU2003242388A1/en not_active Abandoned
- 2003-06-13 AU AU2003242390A patent/AU2003242390A1/en not_active Abandoned
- 2003-06-13 CN CNA038188953A patent/CN1678315A/zh active Pending
- 2003-06-13 PE PE2003000593A patent/PE20040563A1/es not_active Application Discontinuation
- 2003-06-13 EP EP03733426A patent/EP1513527B1/fr not_active Expired - Lifetime
- 2003-06-13 CA CA002489470A patent/CA2489470A1/fr not_active Abandoned
- 2003-06-13 MX MXPA04012396A patent/MXPA04012396A/es not_active Application Discontinuation
- 2003-06-13 AR ARP030102114A patent/AR040221A1/es not_active Application Discontinuation
- 2003-06-13 EP EP03733425A patent/EP1514870A4/fr not_active Withdrawn
- 2003-06-13 WO PCT/JP2003/007545 patent/WO2003106429A1/fr active Application Filing
- 2003-06-13 PL PL03373085A patent/PL373085A1/xx not_active Application Discontinuation
- 2003-06-13 TW TW092116056A patent/TW200307544A/zh unknown
- 2003-06-13 OA OA1200400327A patent/OA12867A/en unknown
- 2003-06-13 JP JP2004513262A patent/JPWO2003106429A1/ja active Pending
- 2003-06-13 BR BR0311801-0A patent/BR0311801A/pt not_active IP Right Cessation
- 2003-06-13 KR KR10-2004-7020371A patent/KR20050009751A/ko not_active Application Discontinuation
- 2003-06-13 WO PCT/JP2003/007546 patent/WO2003105845A1/fr active Application Filing
- 2003-06-13 US US10/517,633 patent/US7410981B2/en not_active Expired - Fee Related
- 2003-06-13 AT AT03733426T patent/ATE437642T1/de not_active IP Right Cessation
- 2003-06-13 US US10/517,847 patent/US20060293371A1/en not_active Abandoned
- 2003-06-13 CA CA002489361A patent/CA2489361A1/fr not_active Abandoned
-
2004
- 2004-12-05 IL IL16556204A patent/IL165562A0/xx unknown
-
2005
- 2005-01-11 NO NO20050141A patent/NO20050141L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL165562A0 (en) | 2006-01-15 |
| CN1678315A (zh) | 2005-10-05 |
| BR0311801A (pt) | 2005-04-12 |
| US20050222210A1 (en) | 2005-10-06 |
| PL373085A1 (en) | 2005-08-08 |
| MXPA04012396A (es) | 2005-06-17 |
| US7410981B2 (en) | 2008-08-12 |
| WO2003106429A1 (fr) | 2003-12-24 |
| EP1513527B1 (fr) | 2009-07-29 |
| DE60328603D1 (de) | 2009-09-10 |
| EP1514870A1 (fr) | 2005-03-16 |
| PE20040563A1 (es) | 2004-10-21 |
| OA12867A (en) | 2006-09-15 |
| CA2489470A1 (fr) | 2003-12-24 |
| AR040221A1 (es) | 2005-03-16 |
| KR20050009751A (ko) | 2005-01-25 |
| NO20050141L (no) | 2005-01-27 |
| TW200307544A (en) | 2003-12-16 |
| NO20050141D0 (no) | 2005-01-11 |
| AU2003242390A1 (en) | 2003-12-31 |
| CA2489361A1 (fr) | 2003-12-24 |
| ATE437642T1 (de) | 2009-08-15 |
| AU2003242388A1 (en) | 2003-12-31 |
| US20060293371A1 (en) | 2006-12-28 |
| EP1513527A1 (fr) | 2005-03-16 |
| WO2003105845A1 (fr) | 2003-12-24 |
| EP1514870A4 (fr) | 2006-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080715 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080912 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090602 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091013 |