JPS649965B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to compositions for skin bleaching and treating skin diseases. Various drugs and compositions have been known for use in bleaching unwanted skin hair, preventing age spots, freckles, sunburn, and the like. For example, hydrogen peroxide is used to bleach unwanted hair, and skin bleaching agents such as hydroquinone are used to prevent age spots, freckles, and sunburn.
Compositions containing vitamin C, vitamin C derivatives, crude drug extracts, etc. are known. However, these drugs and compositions have drawbacks such as being highly irritating to the skin, and conversely, those that are less irritating may take a long time to develop their efficacy or are insufficiently effective. It is difficult to use these to remove spots, freckles, bruises, etc. without irritating the skin. Furthermore, in recent years, skin disorders caused by cosmetics, particularly dark brown skin discoloration due to melasma, have become a major problem, and it is considered to be extremely difficult to remove such skin discoloration. However, the present inventor surprisingly found that by using a three-dose or two-dose composition containing a sulfur-containing compound with a reducing action and certain ingredients, it was found that no harmful irritation was caused to the skin. He discovered that it was possible to remove not only stains and freckles, but also bruises and skin discoloration caused by melasma in a very short period of time without causing irritation or inflammation.
Patent No. 1051060) was obtained. The inventor continued to conduct intensive research, and found that
By adding new ingredients to the above-mentioned patented composition, an even more excellent skin bleaching effect can be obtained, and it can also be used to treat skin diseases such as acne, pimples, mold-like and other eczema, athlete's foot, and skin diseases. The present invention was completed based on the discovery that it is possible to obtain a composition that is also extremely effective. That is, the present invention provides a first composition containing animal liver oil, a basic fourth composition containing a sulfur-containing compound, a fifth composition containing hydrogen peroxide and salicylic acid, and an acidic composition containing bromate. A 4-dose type comprising a sixth composition, and a 5-dose type using a second composition containing raw egg white next to the first composition; Next, the present invention relates to a 6-dose composition for skin bleaching and skin disease treatment using a third composition containing egg yolk oil or a lecithin-oil mixture. In the present invention, it is also advantageous to use the third composition and the fourth composition after being mixed and aged in advance. Although the mechanism of action of the composition of the present invention is not clear, by using the composition of the present invention several times,
It can remove age spots, freckles, birthmarks (especially acquired ones), and skin discoloration caused by melasma without causing any harmful irritation or inflammation to the skin. In particular, the third and fourth aspects of the present invention
A composition prepared by aging the composition in advance causes almost no irritation to the skin, can completely suppress the specific odor of the sulfur-containing compound, and has an extremely good feeling of use. In addition, the composition of the present invention not only has the effect of bleaching the skin, but also has the effect of preventing acne and wrinkles. It is extremely effective against mold-like and other skin diseases that have been considered to be diseases, and is also useful as a therapeutic agent for skin diseases. Various animal liver oils can be used as the essential component of the first composition of the present invention, and fatty oils obtained from the livers of fish such as shark, cod, squid, and whales are particularly preferred. The raw egg white of the second composition is usually preferably raw chicken egg white. The egg yolk oil used as an essential component of the third composition is
Preferred are organic solvent extracts, such as ether extracts of chicken egg yolks, especially ether extracts. The lecithin-oil mixture may also be prepared by combining egg yolk lecithin or soybean lecithin with a vegetable oil such as soybean oil, olive oil, etc., preferably soybean oil, preferably in a lecithin:vegetable oil weight ratio of 30-40:70-60.
It is a mixture as follows. These components may be used alone as the third composition. Additionally, if desired, other ingredients such as olive oil and honey may be added to the third composition, up to a maximum of about 50%
% (weight %, the same applies hereinafter) may be added, thereby improving the feeling of use. Examples of the sulfur-containing compound used as an essential component of the fourth composition include basic salts of mercaptans such as thioglycolic acid, thiolactic acid, thiopropionic acid, thiosalicylic acid, and thiobutyric acid, preferably ammonium thioglycolic acid. Salts, ethylenediamine salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, etc., bisulfites such as sodium bisulfite, cysteine (including L, D, DL forms), etc.
Particular preference is given to ammonium thioglycolate. These sulfur-containing compounds are usually blended in a proportion of about 1 to 10%, preferably about 3 to 6%, in the fourth composition, and the fourth composition contains, for example, sodium hydroxide, potassium hydroxide, sodium carbonate. , basic using ammonia etc., preferably about 7.5-8.5
Adjust to PH. In the fifth composition, hydrogen peroxide is typically about 1 to 40%
%, especially about 3 to 10%, and commercially available oxidols can be used. The fifth composition is a hydrogen peroxide solution containing salicylic acid of about 0.1 to
It is prepared by dissolving 30%, preferably about 1 to 20%, and it is particularly desirable to prepare it immediately before use. Essential components of the sixth composition include bromates, for example alkali metal bromates such as sodium or potassium bromate, which may be used alone or in admixture, preferably potassium bromate. Use salt. This component is usually blended in the sixth composition at about 10%, preferably about 3 to 6%,
The sixth composition includes, for example, citric acid, oxalic acid,
The pH is adjusted to be acidic, preferably about 5.5 to 6.5, with succinic acid, acetic acid, benzoic acid, etc. Further, in the present invention, the third composition and the fourth composition are uniformly mixed at a weight ratio of 9 to 5:1 to 5, and the mixture is heated at 10 to 30°C, preferably at room temperature. By holding and aging for 1 to 3 days, preferably about 1 day, the characteristic odor of the sulfur-containing compound can be suppressed and the usability can be improved without affecting the effect at all. To give one preferred example of applying the composition of the present invention, first, the first composition is applied to a colored part of the skin or a part to be treated, rubbed in, and then treated with the second composition in the same manner. Thereafter, the third composition is applied and pine surge is performed, and then the fourth composition is taken on cotton gauze, etc., applied by dabbing, pine surge is performed, and after being left for several minutes, it is wiped off. Even when a mixture of the third composition and the fourth composition is used, pine surge is performed after application, and the mixture is left for several minutes and then wiped off. Next, the fifth composition is applied, and after being left for a while, the sixth composition is finally treated in the same manner as the fourth composition. Thus, any of the compositions of the invention may be mixed,
They can be formulated into dosage forms such as solutions, emulsions, gels, creams, aerosols, etc. by conventional methods such as dissolution. Next, the present invention will be explained in more detail with reference to Examples. Example 1 First composition Shark liver oil 100% Fourth composition Ammonium thioglycolate 5% Sodium hydroxide Adjusted to PH8.0 Water Adjusted to 100% Fifth composition Hydrogen peroxide (6%) 20c.c. Salicylic acid 2g Sixth composition Potassium bromate 5% Citric acid Adjusted to PH6.5 Water Adjusted to 100% A composition of the present invention was obtained using each of the above components. Example 2 First composition Shark liver oil 100% Second composition Raw egg white 100% Fourth composition Ammonium thioglycolate 3% Sodium hydroxide Adjusted to PH8.0 Water Adjusted to 100% Fifth composition Hydrogen peroxide (6%) 10c.c. Salicylic acid 1.5g Sixth composition Potassium bromate 3% Citric acid Adjusted to PH6.5 Water Adjusted to 100% A composition of the present invention was obtained using the above components. Example 3 First composition Shark liver oil 100% Second composition Raw egg white 100% Mixture A of third and fourth compositions Ingredients Soybean lecithin-soybean oil (1:1 mixture by weight)
85% Olive oil 10% Honey 5% B Ingredients Ammonium thioglycolate 5% Sodium hydroxide Adjusted to PH8.0 Water Adjusted to 100% Fifth composition Hydrogen peroxide (6%) 25cc. Salicylic acid 3g Sixth composition Potassium bromate 5% Citric acid Adjusted to PH6.5 Water Adjusted to 100% Component A and B were each added according to the usual method.
The two liquid compositions obtained by mixing separately are mixed uniformly at a weight ratio of 7:3 and kept at room temperature for one day to age. A composition of the present invention was obtained using each of the above components. Example 4 First composition Cod liver oil 100% Second composition Raw egg white 100% Mixture of third and fourth compositions A Component Egg yolk oil 100% B Component Ammonium thioglycolate 5% Sodium hydroxide pH 8.0 Adjustment Water Adjusted to 100% 5th composition Hydrogen peroxide (6%) 30cc. Salicylic acid 2g 6th composition Potassium bromate 5% Citric acid Adjusted to PH6.5 Water Adjusted to 100% Component B in the usual manner Therefore, they are mixed uniformly at a ratio of 8:2 of component A: component B, and kept at room temperature for one day to ripen. A composition of the present invention was obtained using each of the above components. Next, the results of testing the bleaching effect and skin irritation of the composition of the present invention are shown. (1) Depigmentation effect One dose of the composition of Example 1 was given to 10 melasma patients.
The product was used at weekly intervals, and the increase in the bleached area relative to the skin colored area before use was visually observed, and the bleaching effect was determined according to the following evaluation. Very good bleaching effect: 80-100% bleached area Good bleaching effect: 50-80% bleached area Good bleaching effect: 20-50% bleached area Poor bleaching effect: 20% or less bleached area Judgment as shown in Table 1-A below Show the results. The numbers in the table mean the number of people who showed the corresponding bleaching effect.

[Table] Next, the decolorizing effect was determined in the same manner using the composition of Example 3, and the results are shown in Table 1-B.

[Table] (2) Skin irritation The composition of Example 1,
The composition of Example 4 and the composition of Example 1 except for the first composition as a control were used to conduct sensitivity tests for irritation and odor when applied to the skin. The results are shown in Table 2 below. The numbers in the table mean the number of people.

[Table] As is clear from the results, the composition of the present invention does not cause harmful irritation to the skin;
The sulfur odor of sulfur-containing compounds is suppressed and the usability is excellent. Example 5 Vanishing cream type composition base formulation Beeswax 2.5% Stearic acid 8.0% Setanol 3.0% Lanolin 1.0% IPM 5.0% Liquid paraffin 10.5% Polyoxyethylene sorbitan monostearate 4.0% Sorbitan monolaurate 1.0% Triethanolamine 0.5% Glycerin 4.0% Water Adjust to 100% A cream base is prepared using this recipe according to a conventional method. Mixture A of third and fourth compositions Ingredients Soybean lecithin-soybean oil (weight ratio 1:1)
85% Olive oil 10% Honey 5% B Component Ammonium thioglycolate 5% Sodium hydroxide Adjusted to PH8.0 Water Adjusted to 100% As in Example 3, component A and component B were mixed separately, and these components were mixed separately. were sequentially added to the base obtained above (A:B=7:3), mixed uniformly, and then aged at room temperature for one day to obtain a mixed composition. A vanishing cream type composition was obtained in the same manner as in Example 3 except that the above mixed composition was used. Next, the results of testing the therapeutic effect of the composition of the present invention on skin diseases will be shown. (1) Treatment effect for acne breakouts When the composition of Example 1 was used to treat acne that appeared on the face of a 25-year-old woman, the surface suppuration disappeared, and a second treatment was performed. The lump inside disappeared. During this time, the acne that appeared during the first and second treatments also disappeared. After the third treatment, the acne was almost completely cured, and from the fourth treatment, the acne scars were removed. (2) Treatment effect for athlete's foot The athlete's foot was completely cured in 3 to 4 treatments in the same way as for acne. (3) Effect on the treatment of mold-like skin disease The mold-like skin disease that occurred all over the body of a 50-year-old man had been tried for many years by various methods, but it was not cured, but the composition of Example 3 of the present invention When the patient received medical treatment, he was almost completely cured after about 6 treatments.

Claims (1)

[Claims] 1. A first composition containing animal liver oil, a basic fourth composition containing a sulfur-containing compound, a fifth composition containing hydrogen peroxide and salicylic acid, and a bromate salt. A 4-dose composition for skin bleaching and skin disease treatment, characterized by comprising an acidic sixth composition. 2. A first composition containing animal liver oil, a second composition containing raw egg white, a basic fourth composition containing a sulfur-containing compound, a fifth composition containing hydrogen peroxide and salicylic acid, and bromine. A 5-dose composition for skin bleaching and skin disease treatment, characterized by comprising an acidic sixth composition containing an acid salt. 3. A first composition containing animal liver oil, a second composition containing raw egg white, a third composition containing egg yolk oil or a lecithin-oil mixture, and a basic fourth composition containing a sulfur-containing compound. Alternatively, a six-dose form comprising a mixture of these third and fourth two compositions, a fifth composition containing hydrogen peroxide and salicylic acid, and an acidic sixth composition containing bromate. Or a 5-dose composition for skin bleaching and skin disease treatment. 4. The composition of claim 3, wherein the lecithin-oil mixture of the third composition is a mixture of lecithin:vegetable oil in a weight ratio of 30-40:70-60. 5 The sulfur-containing compound of the fourth composition is a basic salt of thioglycolic acid, a basic salt of thiolactic acid, a basic salt of thiopropionic acid, a basic salt of thiosalicylic acid,
The composition according to any one of claims 1 to 3, which is a basic salt, bisulfite, or cysteine of thiobutyric acid. 6. The composition according to any one of claims 1 to 3, wherein the fourth composition has a pH of about 7.5 to 8.5. 7. The composition according to any one of claims 1 to 3, wherein the bromate of the sixth composition is an alkali metal salt of bromate. 8. The composition according to any one of claims 1 to 3, wherein the sixth composition has a pH of about 5.5 to 6.5.