JPS647043B2 - - Google Patents

Description

[Detailed description of the invention]

INDUSTRIAL APPLICABILITY The present invention provides a skin cosmetic that has excellent effects in protecting the skin and imparting moisture to the skin. More specifically, the present invention relates to a useful skin cosmetic with good viscosity stability, which is made by mixing hyaluronic acid and/or its salt and a water-soluble thickener with another cosmetic base. Generally, skin is said to be healthy when the stratum corneum contains 10 to 15% water. If the skin contains too much water, it will become flaky, and if it contains too little water, it will become dry. To solve this problem, cosmetics such as lotions, creams, and milky lotions are used. In these cosmetics, moisturizing agents such as sodium lactate, glycerin, sodium pyrrolidone carboxylate, propylene glycol, etc. are used in relatively large amounts (3-10%) from the viewpoint of affinity for the skin and feeling of use. Cosmetics that appeal to the senses contain a very large amount of ingredients, which tends to cause a sticky feeling on the skin.Furthermore, when used in low humidity conditions, the absence of outside air humidity causes the skin to absorb into the moisturizing agent-containing cosmetics. On the other hand, it can absorb moisture and dry out your skin. Moreover, the viscosity of an aqueous solution of hyaluronic acid is extremely susceptible to change, making it difficult to use cosmetics containing the hyaluronic acid. In other words, these days, general skin cosmetics are not manufactured immediately before use, but rather are displayed in stores after they are manufactured.
It is used after a storage period at home.
For this reason, the period from manufacture to actual use varies, and skin cosmetics that do not change over time are required. In this regard, cosmetics containing hyaluronic acid have a large viscosity change, which causes the system to become unstable, resulting in changes in the dispersion state or usability of the cosmetic, resulting in loss of product characteristics and the occurrence of defective products. It had this problem. The present inventors have conducted intensive research into a highly stable system in order to solve the drawbacks of cosmetics obtained by simply blending the above-mentioned moisturizing agents as cosmetic ingredients, and to obtain cosmetics that are better than ever before. As a result, we have completed the present invention. The present invention comprises hyaluronic acid and/or a salt thereof, and one or more water-soluble thickeners selected from polyamino acids or salts thereof, polyacrylic acid or salts thereof, pullulan, carboxymethylcellulose, and xanthan gum. This product is related to skin cosmetics that contain hyaluronic acid, which prevents the viscosity of hyaluronic acid from decreasing over time and forms a protective film on the skin, making the skin smooth and providing appropriate ``moisture'' and ``firmness.'' A cosmetic with good compatibility with the skin was obtained. The amount of hyaluronic acid and its salt used in the present invention is 0.01 to 3.0%, preferably 0.05 to 1.0%. If the content is higher than this, a thick film will be formed on the skin, resulting in a lack of affinity with the skin. In addition, since it becomes mushy, the stability of the cosmetic containing a water-soluble thickener is impaired. On the other hand, if the amount is small, sufficient effects of hyaluronic acid and/or its salts cannot be expected as cosmetics. In addition, hyaluronic acid is a polysaccharide whose unit is equal moles of glucuronic acid and N-acetylglucosamine, regardless of the extraction method, purification method, etc., whether it is a natural product, extracted by microbial culture, or synthetic. Any acid is fine. Furthermore, hyaluronic acid salts include sodium,
Potassium, basic amino acid salts, etc. are used. Further, the amount of the water-soluble thickener added is 0.01 to 5.0%, preferably 0.05 to 4.0%. As water-soluble thickeners, polyamino acids or their salts, polyacrylic acids or their salts, pullulan, carboxymethyl cellulose and xanthan gum are used in the present invention. In addition, synthetic polymers such as polyethylene glycol, polyvinyl alcohol, polyacrylonitrile, and polyvinylpyrrolidone, semi-synthetic polymers such as hydroxyethyl cellulose, methyl cellulose, cellulose sulfate, glyceryl starch, and sodium carboxymethyl dextran, starch, carrageenan, and quince. Natural polymers such as mucilage, agar, gum arabic, alginate, gum tragacanth, and pectin, and clay minerals such as bentone and vegum, have been used, but they have not been very effective. Next, the effects of the present invention will be explained. Sodium hyaluronate (average molecular weight 1 million)
The viscosity of an aqueous solution with a concentration of 0.1% was measured by adding 0.025%, 0.075%, 0.1%, and 0.2% of this sodium hyaluronate and sodium polyglutamate (average molecular weight 70,000), respectively, and the viscosity change was measured by leaving the solution at 50°C.

[Table] As shown in the table above, it was found that the viscosity of all combinations of sodium hyaluronate and sodium polyglutamate was stabilized. The table also shows the results of measuring changes in viscosity between a 0.1% sodium hyaluronate aqueous solution and other water-soluble thickeners. As comparative examples, we measured 0.1% sodium hyaluronate aqueous solution and 0.1% polyethylene glycol (average molecular weight 20,000) added, and 0.1% sodium hyaluronate aqueous solution and 0.1% clay mineral (Laponite CP. trade name) aqueous solution added. .

[Table] As shown in the table above, it was found that the viscosity was stabilized in all cases of combinations of sodium hyaluronate, sodium polyacrylate, and pullulan. By blending the system thus obtained with other cosmetic bases, stable and excellent cosmetics were obtained. The cosmetics of the present invention include ordinary skin conditioning and nutritional lotions, as well as cosmetic lotions such as astringent lotions, shave lotions, body lotions, water-based cosmetics such as liquid packs, nutritional creams, and eye care lotions. The main products include creams such as creams, body creams, hand creams, pine surge creams, and cold creams, emulsions such as nutritional emulsions, body emulsions, net emulsions, and hand emulsions, and packs. Moreover, the PH range of the cosmetic is 4 to 10, and it is not necessary to use a PH adjuster. Other cosmetic bases include surfactants, oils,
Those commonly used as ingredients for cosmetics are selected, such as humectants, ultraviolet absorbers, alcohols, chelating agents, preservatives, thickeners, pigments, and fragrances. Next, the cosmetics of the present invention will be shown. The blending amount indicates weight %. Example 1 Lotion % Ethanol 8.0 1.3 Butylene glycol 5.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.2 Hyaluronic acid 0.3 Pullulan 0.05 Methyl paraben 0.1 Caustic potash 0.015 ETDA-3Na 0.01 Fragrance 0.1 Ion exchange water Remaining amount Example 2 Cream % 1.3 Butylene Glycol 7.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 moles) oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Sodium hyaluronate 0.1 Xanthan gum (Keltrol brand name)
0.05 Methylparaben 0.1 Ethylparaben 0.2 Caustic potash 0.01 EDTA−3Na 0.01 Fragrance 0.2 Ion exchange water Remaining amount Example 3 Emulsion % 1.3 Butylene glycol 8.0 Glycerin 2.0 Squalane 5.0 Vaseline 1.0 Cetostearyl alcohol 0.3 Polyoxyethylene (20 mol) Oleyl alcohol Tel 1.5 Grise Reel monooleate 1.5 Sodium hyaluronate 0.1 Sodium polyglutamate (average molecular weight 70,000) 0.03 Sodium polyacrylate 0.03 Ethylparaben 0.2 Caustic potash 0.1 EDTA-3Na 0.03 Fragrance 0.2 Ion exchange water Remaining amount Example 4 Pack % Polyethylene glycol 4000 3.0 Glycerin 2.0 Ethanol 10.0 Hyaluronic Acid 0.2 Carboxymethylcellulose 0.07 Methylparaben 0.1 Ethylparaben 0.1 Caustic Potassium 0.02 EDTA−3Na 0.01 Fragrance 0.1 Ion-exchanged water Remaining amount

Claims (1)

[Claims] 1 Contains hyaluronic acid and/or a salt thereof, and one or more water-soluble thickeners selected from polyamino acids or salts thereof, polyacrylic acid or salts thereof, pullulan, carboxymethylcellulose, and xanthan gum. A skin cosmetic product featuring: