JPS646263A - Novel thiazolidine derivative, its production and antiamnestic agent containing same - Google Patents

Novel thiazolidine derivative, its production and antiamnestic agent containing same

Info

Publication number
JPS646263A
JPS646263A JP63038675A JP3867588A JPS646263A JP S646263 A JPS646263 A JP S646263A JP 63038675 A JP63038675 A JP 63038675A JP 3867588 A JP3867588 A JP 3867588A JP S646263 A JPS646263 A JP S646263A
Authority
JP
Japan
Prior art keywords
formula
antiamnestic
single bond
production
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63038675A
Other languages
Japanese (ja)
Other versions
JP2526084B2 (en
Inventor
Masaaki Toda
Shuichi Ouchida
Hiroyuki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP63038675A priority Critical patent/JP2526084B2/en
Publication of JPS646263A publication Critical patent/JPS646263A/en
Application granted granted Critical
Publication of JP2526084B2 publication Critical patent/JP2526084B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:The thiazolidine derivative of formula I [R is G-E-D-B-A-; A and B are single bond or 1-6C alkylene, A may be 2-6C alkenylene or group of formula II-III; Y is 1-4C alkylene or 2-4C alkenylene; D is single bond, O, CO or group of formula IV-V; R<1> is H, 1-4C alkyl, phenyl or benzyl; E is single bond or 1-8C alkylene which may have substituent (phenyl or ben zyl); G is carbon ring or heterocyclic group which may have 1-3 substituents (1-6C alkyl, halogen, CF3 or NO2); A and B are not single bond at the same time]. EXAMPLE:4(R)-3-[3-[N-(4-methylbenzyl)carbamoyl]propionyl]thiazolidin-4 -al. USE:A prolylendopeptitase inhibitor useful as an antiamnestic agent. PREPARATION:The compound of formula I can be produced by oxidizing a compound of formula VI [R<h> is G-E-D<h>-B-A-; D<h> is D or CH(OH)] under mild condition.
JP63038675A 1987-02-23 1988-02-23 Novel thiazolidine derivative Expired - Lifetime JP2526084B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63038675A JP2526084B2 (en) 1987-02-23 1988-02-23 Novel thiazolidine derivative

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-37844 1987-02-23
JP3784487 1987-02-23
JP63038675A JP2526084B2 (en) 1987-02-23 1988-02-23 Novel thiazolidine derivative

Publications (2)

Publication Number Publication Date
JPS646263A true JPS646263A (en) 1989-01-10
JP2526084B2 JP2526084B2 (en) 1996-08-21

Family

ID=26376995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63038675A Expired - Lifetime JP2526084B2 (en) 1987-02-23 1988-02-23 Novel thiazolidine derivative

Country Status (1)

Country Link
JP (1) JP2526084B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01226880A (en) * 1988-03-07 1989-09-11 Kissei Pharmaceut Co Ltd Thiazolidine derivative
WO1990006919A1 (en) * 1988-12-14 1990-06-28 Kabushiki Kaisha Yakult Honsha New thioproline derivative
WO1990012005A1 (en) * 1989-04-13 1990-10-18 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
WO1991018877A1 (en) * 1990-06-07 1991-12-12 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
JPH05506442A (en) * 1990-06-04 1993-09-22 ファイザー・インコーポレーテッド Aromatic pyrrolidine and thiazolidine amides
WO1994012474A1 (en) 1992-11-20 1994-06-09 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
WO1995019356A1 (en) * 1994-01-18 1995-07-20 Santen Pharmaceutical Co., Ltd. Endopeptidase 24.15 inhibitor

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01226880A (en) * 1988-03-07 1989-09-11 Kissei Pharmaceut Co Ltd Thiazolidine derivative
WO1990006919A1 (en) * 1988-12-14 1990-06-28 Kabushiki Kaisha Yakult Honsha New thioproline derivative
WO1990012005A1 (en) * 1989-04-13 1990-10-18 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
JPH05506442A (en) * 1990-06-04 1993-09-22 ファイザー・インコーポレーテッド Aromatic pyrrolidine and thiazolidine amides
WO1991018877A1 (en) * 1990-06-07 1991-12-12 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
EP0536399A1 (en) * 1990-06-07 1993-04-14 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
US5407950A (en) * 1990-06-07 1995-04-18 Zeria Pharmaceutical Co., Ltd. Arylalkanoylamine derivative and drug containing the same
EP0536399B1 (en) * 1990-06-07 1996-01-24 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
WO1994012474A1 (en) 1992-11-20 1994-06-09 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
WO1995019356A1 (en) * 1994-01-18 1995-07-20 Santen Pharmaceutical Co., Ltd. Endopeptidase 24.15 inhibitor

Also Published As

Publication number Publication date
JP2526084B2 (en) 1996-08-21

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