JPS6461482A - Dehydrocamptothecin and production thereof - Google Patents
Dehydrocamptothecin and production thereofInfo
- Publication number
- JPS6461482A JPS6461482A JP21536987A JP21536987A JPS6461482A JP S6461482 A JPS6461482 A JP S6461482A JP 21536987 A JP21536987 A JP 21536987A JP 21536987 A JP21536987 A JP 21536987A JP S6461482 A JPS6461482 A JP S6461482A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- organic solvent
- dehydrocamptothecin
- production
- feetide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000060380 Nothapodytes Species 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21536987A JPS6461482A (en) | 1987-08-31 | 1987-08-31 | Dehydrocamptothecin and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21536987A JPS6461482A (en) | 1987-08-31 | 1987-08-31 | Dehydrocamptothecin and production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6461482A true JPS6461482A (en) | 1989-03-08 |
| JPH0533955B2 JPH0533955B2 (enrdf_load_stackoverflow) | 1993-05-20 |
Family
ID=16671153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21536987A Granted JPS6461482A (en) | 1987-08-31 | 1987-08-31 | Dehydrocamptothecin and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6461482A (enrdf_load_stackoverflow) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US5525609A (en) * | 1994-05-30 | 1996-06-11 | Indena S.P.A. | Alkaloids from Mappia foetida, the use thereof and formulations containing them |
| US5608066A (en) * | 1993-02-25 | 1997-03-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US6218399B1 (en) | 1996-01-30 | 2001-04-17 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6893668B2 (en) * | 2003-03-31 | 2005-05-17 | Council Of Scientific And Industrial Research | Process for isolation of anticancer agent camptothecin from Nothapodytes foetida |
| WO2007126046A1 (ja) | 2006-04-27 | 2007-11-08 | Kabushiki Kaisha Yakult Honsha | カンプトテシン誘導体の製造方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0576680U (ja) * | 1992-03-04 | 1993-10-19 | 千住金属工業株式会社 | 自動はんだ付け装置用プリヒータ |
| CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4832900A (enrdf_load_stackoverflow) * | 1971-08-26 | 1973-05-02 | ||
| JPS49117499A (enrdf_load_stackoverflow) * | 1973-03-26 | 1974-11-09 | ||
| JPS5198300A (en) * | 1975-02-20 | 1976-08-30 | Kanputoteshin oyobi sonoruijitaino seizoho | |
| JPS62195384A (ja) * | 1986-02-24 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
-
1987
- 1987-08-31 JP JP21536987A patent/JPS6461482A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4832900A (enrdf_load_stackoverflow) * | 1971-08-26 | 1973-05-02 | ||
| JPS49117499A (enrdf_load_stackoverflow) * | 1973-03-26 | 1974-11-09 | ||
| JPS5198300A (en) * | 1975-02-20 | 1976-08-30 | Kanputoteshin oyobi sonoruijitaino seizoho | |
| JPS62195384A (ja) * | 1986-02-24 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US5608066A (en) * | 1993-02-25 | 1997-03-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US6107486A (en) * | 1993-02-25 | 2000-08-22 | The Stehlin Foundation For Cancer Research | Method for purifying 20(S)-camptothecin |
| US5525609A (en) * | 1994-05-30 | 1996-06-11 | Indena S.P.A. | Alkaloids from Mappia foetida, the use thereof and formulations containing them |
| US6218399B1 (en) | 1996-01-30 | 2001-04-17 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6407239B1 (en) | 1999-08-03 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6893668B2 (en) * | 2003-03-31 | 2005-05-17 | Council Of Scientific And Industrial Research | Process for isolation of anticancer agent camptothecin from Nothapodytes foetida |
| WO2007126046A1 (ja) | 2006-04-27 | 2007-11-08 | Kabushiki Kaisha Yakult Honsha | カンプトテシン誘導体の製造方法 |
| US8476438B2 (en) | 2006-04-27 | 2013-07-02 | Kabushiki Kaisha Yakult Honsha | Process for production of camptothecin derivative |
| JP5238493B2 (ja) * | 2006-04-27 | 2013-07-17 | 株式会社ヤクルト本社 | カンプトテシン誘導体の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0533955B2 (enrdf_load_stackoverflow) | 1993-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |