JPS6460399A - Production of optically active phenethyl alcohol derivative - Google Patents
Production of optically active phenethyl alcohol derivativeInfo
- Publication number
- JPS6460399A JPS6460399A JP11447088A JP11447088A JPS6460399A JP S6460399 A JPS6460399 A JP S6460399A JP 11447088 A JP11447088 A JP 11447088A JP 11447088 A JP11447088 A JP 11447088A JP S6460399 A JPS6460399 A JP S6460399A
- Authority
- JP
- Japan
- Prior art keywords
- phenethyl alcohol
- alcohol derivative
- esterase
- formula
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To efficiently produce a phenethyl alcohol derivative useful as an intermediate of medicines, liquid crystal materials, etc., by asymmetrically hydrolyzing specific dl-esters by the use of a special esterase. CONSTITUTION:dl-Esters of formula I (R' and R'' are lower alkyl) are asymmetrically hydrolyzed with an esterase having an ability of hydrolyzing either of the ester enantiomers to give an optically active phenethyl alcohol derivative of formula II (R is -H or -COR''; * is asymmetrical carbon). The esterase is preferably a lipase produced by microorganisms belonging to genus Pseudomonas or Arthrobacter because the lipase provides a relatively high optical purity for the derivative of formula II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11622087 | 1987-05-12 | ||
JP62-116220 | 1987-05-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6460399A true JPS6460399A (en) | 1989-03-07 |
JP2689478B2 JP2689478B2 (en) | 1997-12-10 |
Family
ID=14681801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11447088A Expired - Lifetime JP2689478B2 (en) | 1987-05-12 | 1988-05-10 | Process for producing optically active phenethyl alcohol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2689478B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007523447A (en) * | 2004-01-13 | 2007-08-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Fluid flow sensor for X-ray tube |
-
1988
- 1988-05-10 JP JP11447088A patent/JP2689478B2/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007523447A (en) * | 2004-01-13 | 2007-08-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Fluid flow sensor for X-ray tube |
Also Published As
Publication number | Publication date |
---|---|
JP2689478B2 (en) | 1997-12-10 |
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