JPS6460391A - Production of gamma-halo-beta(r)-hydroxybutyric acid ester - Google Patents

Production of gamma-halo-beta(r)-hydroxybutyric acid ester

Info

Publication number
JPS6460391A
JPS6460391A JP62218975A JP21897587A JPS6460391A JP S6460391 A JPS6460391 A JP S6460391A JP 62218975 A JP62218975 A JP 62218975A JP 21897587 A JP21897587 A JP 21897587A JP S6460391 A JPS6460391 A JP S6460391A
Authority
JP
Japan
Prior art keywords
gamma
acid ester
halo
beta
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62218975A
Other languages
Japanese (ja)
Inventor
Masayasu Hasegawa
Hiroshi Honda
Yasuto Watanabe
Shigetaka Okada
Nobutake Hamada
Kiyobumi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Synthetic Chemical Industry Co Ltd
Osaka City
Original Assignee
Nippon Synthetic Chemical Industry Co Ltd
Osaka City
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Synthetic Chemical Industry Co Ltd, Osaka City filed Critical Nippon Synthetic Chemical Industry Co Ltd
Priority to JP62218975A priority Critical patent/JPS6460391A/en
Publication of JPS6460391A publication Critical patent/JPS6460391A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals such as carnitine or GABOB, in high efficiency, by reducing a gamma-haloacetoacetic acid ester with an enzyme extracted from bakers' yeast and having a specific molecular weight. CONSTITUTION:The enzyme used in the present process has the following properties: mol.wt., 55,000-68,000; optimum pH, 5.5; stable pH range, 6.5-8.0; optimum temperature, 30 deg.C; isoelectric point, pH 5.1; inhibition, inhibited by Cu, Hg, etc.; etc. A proper amount of the enzyme is added to water or a buffer solution of pH 4-8 containing 0.1-10% of a gamma-haloacetoacetic acid ester and is made to react at 15-40 deg.C for 1min-50hr under agitation. The objective gamma-halo-beta(R)- hydroxybutyric acid ester is produced from the obtained reaction product e.g. by solvent extraction.
JP62218975A 1987-08-31 1987-08-31 Production of gamma-halo-beta(r)-hydroxybutyric acid ester Pending JPS6460391A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62218975A JPS6460391A (en) 1987-08-31 1987-08-31 Production of gamma-halo-beta(r)-hydroxybutyric acid ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62218975A JPS6460391A (en) 1987-08-31 1987-08-31 Production of gamma-halo-beta(r)-hydroxybutyric acid ester

Publications (1)

Publication Number Publication Date
JPS6460391A true JPS6460391A (en) 1989-03-07

Family

ID=16728296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62218975A Pending JPS6460391A (en) 1987-08-31 1987-08-31 Production of gamma-halo-beta(r)-hydroxybutyric acid ester

Country Status (1)

Country Link
JP (1) JPS6460391A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04343647A (en) * 1991-05-17 1992-11-30 Kilony Sangyo Kk Copying detector
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04343647A (en) * 1991-05-17 1992-11-30 Kilony Sangyo Kk Copying detector
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
US8273547B2 (en) 2006-10-02 2012-09-25 Codexis, Inc. Engineered ketoreductases and methods for producing stereoisomerically pure statins
US8617864B2 (en) 2006-10-02 2013-12-31 Codexis, Inc. Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor

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