DK0876329T3 - Process for the preparation of N-acetyl-D, L-alpha-aminocarboxylic acids - Google Patents

Process for the preparation of N-acetyl-D, L-alpha-aminocarboxylic acids

Info

Publication number
DK0876329T3
DK0876329T3 DK96943039T DK96943039T DK0876329T3 DK 0876329 T3 DK0876329 T3 DK 0876329T3 DK 96943039 T DK96943039 T DK 96943039T DK 96943039 T DK96943039 T DK 96943039T DK 0876329 T3 DK0876329 T3 DK 0876329T3
Authority
DK
Denmark
Prior art keywords
alpha
acetyl
aminocarboxylic acids
aminocarboxylic
acetylation
Prior art date
Application number
DK96943039T
Other languages
Danish (da)
Inventor
Karlheinz Drauz
Andreas Bommarius
Michael Karrenbauer
Guenter Knaup
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Application granted granted Critical
Publication of DK0876329T3 publication Critical patent/DK0876329T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Abstract

Known acetylation processes for producing N-acetyl-D,L- alpha -aminocarboxylic acids from the corresponding D,L- alpha -aminocarboxylic acids by acetylation with acetic anhydride in acetic acid and isolation of the resulting N-acetyl-D,L- alpha -aminocarboxylic acids from the acetylation mixture either result in the production of large quantities of salts or require an aqueous treatment to isolate the N-acetylated alpha -amino acids in sufficiently pure form. By carrying out the acetylation at 60-150 DEG C in a concentration of < 3 mol alpha -aminocarboxylic acid per litre acetic acid (concentration under standard conditions of pressure and temperature) and obtaining the N-acetyl-D,L- alpha -aminocarboxylic acid by concentration in liquefied or solid form, the aqueous treatment can be dispensed with entirely, although high quality is still obtained in terms of both yield and purity. Also disclosed are N-acetyl-D,L- alpha -aminocarboxylic acids for use in the enzymatic splitting operation in a process for producing optically active alpha -aminocarboxylic acids.
DK96943039T 1995-12-13 1996-12-05 Process for the preparation of N-acetyl-D, L-alpha-aminocarboxylic acids DK0876329T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19546533A DE19546533C2 (en) 1995-12-13 1995-12-13 Process for the preparation of N-acetyl-D, L-alpha-aminocarboxylic acids
PCT/EP1996/005439 WO1997021667A1 (en) 1995-12-13 1996-12-05 Process for the production of n-acetyl-d,l-alpha-aminocarboxylic acids

Publications (1)

Publication Number Publication Date
DK0876329T3 true DK0876329T3 (en) 2001-09-24

Family

ID=7780008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96943039T DK0876329T3 (en) 1995-12-13 1996-12-05 Process for the preparation of N-acetyl-D, L-alpha-aminocarboxylic acids

Country Status (9)

Country Link
EP (1) EP0876329B1 (en)
JP (1) JP4001628B2 (en)
AT (1) ATE203232T1 (en)
AU (1) AU1190797A (en)
DE (2) DE19546533C2 (en)
DK (1) DK0876329T3 (en)
ES (1) ES2161384T3 (en)
PT (1) PT876329E (en)
WO (1) WO1997021667A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19749555A1 (en) * 1997-11-10 1999-05-12 Henkel Kgaa Enzymatically catalyzed N-acylation of amino acids, protein hydrolyzates and / or their derivatives
US8628684B2 (en) * 2009-05-20 2014-01-14 Basf Se Process for the preparation of a powder comprising one or more derivatives of glycine-N,N diacetic acid and/or one or more derivatives of glutamine-N,N diacetic acid and methylglycine-N,N diacetic acid trisodium salt powder
CN103408474B (en) * 2013-08-28 2015-09-16 重庆紫光化工股份有限公司 High purity N-acetyl-D, the high-efficiency method for producing of L-Methionine
CN112888702B (en) * 2018-11-12 2024-02-02 Cj第一制糖株式会社 Process for preparing N-acetyl dipeptide and N-acetyl amino acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU753844A1 (en) * 1978-01-10 1980-08-07 Научно-производственное объединение "Биохимреактив" Method of preparing n-acetyl-dl-valine

Also Published As

Publication number Publication date
DE19546533C2 (en) 2000-04-27
DE19546533A1 (en) 1997-06-19
AU1190797A (en) 1997-07-03
JP4001628B2 (en) 2007-10-31
WO1997021667A1 (en) 1997-06-19
PT876329E (en) 2001-12-28
EP0876329A1 (en) 1998-11-11
ES2161384T3 (en) 2001-12-01
ATE203232T1 (en) 2001-08-15
DE59607329D1 (en) 2001-08-23
EP0876329B1 (en) 2001-07-18
JP2000501387A (en) 2000-02-08

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