JPS6456616A - Antiulcer agent - Google Patents

Antiulcer agent

Info

Publication number
JPS6456616A
JPS6456616A JP21267287A JP21267287A JPS6456616A JP S6456616 A JPS6456616 A JP S6456616A JP 21267287 A JP21267287 A JP 21267287A JP 21267287 A JP21267287 A JP 21267287A JP S6456616 A JPS6456616 A JP S6456616A
Authority
JP
Japan
Prior art keywords
agent
compound
formula
during storage
inhibitory action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP21267287A
Other languages
Japanese (ja)
Other versions
JPH0676323B2 (en
Inventor
Naoto Matsuishi
Seiichi Murakami
Akira Hisamitsu
Norio Hirabayashi
Kazuyuki Uchiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Tanabe Co Ltd
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Priority to JP21267287A priority Critical patent/JPH0676323B2/en
Publication of JPS6456616A publication Critical patent/JPS6456616A/en
Publication of JPH0676323B2 publication Critical patent/JPH0676323B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To obtain an antiulcer agent, containing a specific benzimidazole derivative, having excellent stability during storage and inhibitory action on various experimental ulcers and useful as a remedy for gastric or duodenal ulcers. CONSTITUTION:An antiulcer agent containing 2-[2-(3,5-dimethyl)pyridylmethyl sulfinyl]-5-cyclopropylmeth-yloxybenzimidazole, expressed by formula II and obtained by oxidizing a sulfide compound expressed by formula I with an oxidiz ing agent (e.g., m-chloroperbenzoic acid) in the presence of a reaction solvent as an active ingredient. Sufficient stability during storage is provided by using the above-mentioned compound without carrying out conversion of the compound into an alkali salt thereof. The agent has excellent inhibitory action on gastric acid secretion due to inhibition of (H<+>+K<+>) ATPase (adenosine triphosphatase) activity by oral administration thereof.
JP21267287A 1987-08-28 1987-08-28 Anti-ulcer agent Expired - Lifetime JPH0676323B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21267287A JPH0676323B2 (en) 1987-08-28 1987-08-28 Anti-ulcer agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21267287A JPH0676323B2 (en) 1987-08-28 1987-08-28 Anti-ulcer agent

Publications (2)

Publication Number Publication Date
JPS6456616A true JPS6456616A (en) 1989-03-03
JPH0676323B2 JPH0676323B2 (en) 1994-09-28

Family

ID=16626486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21267287A Expired - Lifetime JPH0676323B2 (en) 1987-08-28 1987-08-28 Anti-ulcer agent

Country Status (1)

Country Link
JP (1) JPH0676323B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR890100838A (en) * 1988-12-22 1991-03-15 Haessle Ab A novel therapeutic active compound and preparation method therefore.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR890100838A (en) * 1988-12-22 1991-03-15 Haessle Ab A novel therapeutic active compound and preparation method therefore.

Also Published As

Publication number Publication date
JPH0676323B2 (en) 1994-09-28

Similar Documents

Publication Publication Date Title
ATE40884T1 (en) INTERMEDIATE COMPOUNDS FOR THE PRODUCTION OF OMEPRAZOLE.
ZA877400B (en) Novel derivatives of benzimidazoles active as anti-ulcer agents
HUT43589A (en) Process for production of derivatives of piramidine and medical compounds containing thereof as active substance
DE3585652D1 (en) BENZIMIDAZOLE DERIVATIVES AND THEIR PRODUCTION.
EP0283504A1 (en) Compounds
EP0301422A3 (en) Thiomethyl and sulfinylmethyl derivatives having gastric acid antisecretory activity, processes for the preparation thereof and pharmaceutical compositions containing them
IL92799A0 (en) Benzimidazole derivatives with gastric acid inhibition and process for its preparation
JPS6456616A (en) Antiulcer agent
PH24073A (en) Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion
JPS6440467A (en) Novel substituted diphenylimidazole derivative
ES8504790A1 (en) Thiazole derivatives.
IE832456L (en) 3-hydroxy-4-acylbenzene derivatives.
EP0104611A3 (en) Thiatriazine derivatives
ATE3542T1 (en) PHARMACEUTICAL ALCOXYPROPANOLAMINES AND PROCESSES FOR THEIR PREPARATION.
DK0676199T3 (en) Use of trovafloxacin or derivatives thereof for the manufacture of a medicament for the treatment of H. pylori infections
ES8504735A1 (en) 1-(1H-imidazolyl), 1-N-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them.
JPS6456666A (en) Cyclopropylmethoxy-2-mercaptobenzimidazole and production thereof
ES8703868A1 (en) Methoxy-di:methyl-pyridyl methyl-sulphinyl benzimidazole prepn.
JPS5726663A (en) Novel amidine derivative and its preparation
NO176177C (en) Analogous Process for Preparation of Therapeutically Active 2-Amino-Tetrahydroisoquinoline Derivatives
KR930016419A (en) Substituted imidazole derivatives and preparation method thereof
KR900701781A (en) New 1,3,4-thiadiazole derivatives and anti-ulcer agents using the derivatives as an active ingredient
SE8801907D0 (en) NOVEL PHARMACOLOGICAL COMPOUNDS
CS725786A2 (en) Zpusob vyroby novych 2 (2 thienyl)imidazo (4,5 c)pyridinovych derivatu
DK196785A (en) ACID ADDITION SALTS OF A BASIC TIOETER AND PROCEDURE FOR PREPARING THEREOF