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Priority to SE8801907ApriorityCriticalpatent/SE8801907D0/en
Publication of SE8801907D0publicationCriticalpatent/SE8801907D0/en
Priority to GB8911302Aprioritypatent/GB2219584A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Plural Heterocyclic Compounds
(AREA)
Abstract
Novel compounds of the formula <IMAGE> and therapeutically acceptable salts thereof particularly phosphate esters of 1-hydroxymethyl-2-organo-sulphonyl- benzimidazoles, are useful in therapy, particularly as inhibitors of gastric acid secretion and in the treatment of gastrointestinal inflammation, where D is a mono-, di-, or tri-phosphate group; X is SO or S; y is O or I; R<c> is (a) a mono or bicyclic aromatic heterocyclic structure which may be substituted or (b) a benzene or 5- or 6- membered heterocyclic ring linked via a C atom and containing as an alpha -substituent an N-containing group; A is a fused ring system; and R<1>, R<2>, R<3>, R<4> and R<5> are H or substituents.
ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ALFA- (2-OXO-2,4,5,6,7,7A-HEXSAHYDROTIENO- (3,2-C) -5-PYRIDYL) -PHENYL-ACETIC ACID DERIVATIVES.