JPS6445389A - 3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof - Google Patents

3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof

Info

Publication number
JPS6445389A
JPS6445389A JP20088187A JP20088187A JPS6445389A JP S6445389 A JPS6445389 A JP S6445389A JP 20088187 A JP20088187 A JP 20088187A JP 20088187 A JP20088187 A JP 20088187A JP S6445389 A JPS6445389 A JP S6445389A
Authority
JP
Japan
Prior art keywords
formula
expressed
dihydroxyphosphinyl
amino
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP20088187A
Other languages
Japanese (ja)
Other versions
JPH0523275B2 (en
Inventor
Tatsuo Oshikawa
Koji Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shizuoka University NUC
Original Assignee
Shizuoka University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shizuoka University NUC filed Critical Shizuoka University NUC
Priority to JP20088187A priority Critical patent/JPS6445389A/en
Publication of JPS6445389A publication Critical patent/JPS6445389A/en
Publication of JPH0523275B2 publication Critical patent/JPH0523275B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I. USE:A synthetic intermediate for peptide derivatives capable of exhibiting physiological activity and antimicrobial properties, industrially, economically and advantageously available in a simplified process. PREPARATION:A 4-iodomethylazetidin-2-one expressed by formula II is reacted with a trialkyl phosphite expressed by the formula P(OR)3 (R is 1-8C alkyl) to provide a 4-(dialkoxyphosphinylmethyl)azetidin-2-one expressed by formula III, which is then hydrolyzed. Furthermore, the compound expressed by formula II which is a starting material is readily obtained by mixing chlorosulfonyl isocyanate with allyl iodide at a low temperature.
JP20088187A 1987-08-13 1987-08-13 3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof Granted JPS6445389A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20088187A JPS6445389A (en) 1987-08-13 1987-08-13 3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20088187A JPS6445389A (en) 1987-08-13 1987-08-13 3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof

Publications (2)

Publication Number Publication Date
JPS6445389A true JPS6445389A (en) 1989-02-17
JPH0523275B2 JPH0523275B2 (en) 1993-04-02

Family

ID=16431792

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20088187A Granted JPS6445389A (en) 1987-08-13 1987-08-13 3-amino-4-(dihydroxyphosphinyl)butanoic acid and production thereof

Country Status (1)

Country Link
JP (1) JPS6445389A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136725A (en) * 1989-11-16 1992-08-11 Sportartikel Fabrik Karl Uhl Gmbh Sports glove, in particular for goalies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136725A (en) * 1989-11-16 1992-08-11 Sportartikel Fabrik Karl Uhl Gmbh Sports glove, in particular for goalies

Also Published As

Publication number Publication date
JPH0523275B2 (en) 1993-04-02

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Legal Events

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R350 Written notification of registration of transfer

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EXPY Cancellation because of completion of term