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Welfide Corp
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Welfide Corp
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Priority to JP10734888ApriorityCriticalpatent/JPS6456661A/en
Publication of JPS6456661ApublicationCriticalpatent/JPS6456661A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I [R<1> and R<2> are H, alkyl, lower alkanoyl, formyl, lower alkoxycarbonyl, amidino, (substituted)cycloalkyl, aryl, aralkyl, aroyl, bendilidene, piperidyl, etc., or R<1> and R<2> form 5-6 membered ring or phthalimide together with N; R<3> is H, OH or aralkyloxy] or acid addition salt thereof. EXAMPLE:trans-4-Aminomethyl-1-(4-pyridylcarbamoyl)cyclohexane.2-oxalic acid salt. USE:A medicine, e.g. an agent for circulatory organ system having antihypertensive action and coronary brain circulation improving action. PREPARATION:For example, a carboxylic acid compound expressed by formula II or reactive derivative thereof is reacted with an aminopyridine compound expressed by formula III in an inert solvent such as tetrahydrofuran at -10-200 deg.C to provide the compound expressed by formula I.
Process for producing new n-(3-hydroxy-4-piperidinyl)-dihydro-benzofurane-, -dihydro-2h-penzopyrane- and -dihydro-benzodioxine-carboxamide derivatives and pharmaceutical compositions containing them
Crystalline 3,4,4-trisubstituted piperidinyl-N-(3-phenylprop-2-YL) carboxylic acid derivatives pharmaceutical compositions containing them and processes for their preparation
Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones.
Magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid, the process for its preparation, and therapeutic compositions which contain it as active principle
A DOXORUBICINE DERIVATIVE, A METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF FOR THE PRODUCTION OF MEDICINAL PRODUCTS.
METHOD FOR PRODUCING 2-(3-PYRIDYL)-TETRAHYDROTHIOPYRAN-2-CARBONIC ACID THIOAMIDE-1-(1R,2R)OXIDES, THE SO OBTAINED 2-(3-PYRIDYL)-TETRAHYDROTHIOPYRAN-2-CARBOTHIOPYRAN-2-CARBOTHIOPYRAN-1-(1R,2R )OXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.