JPS643170A - Novel process for producing pyridine derivative - Google Patents
Novel process for producing pyridine derivativeInfo
- Publication number
- JPS643170A JPS643170A JP15630187A JP15630187A JPS643170A JP S643170 A JPS643170 A JP S643170A JP 15630187 A JP15630187 A JP 15630187A JP 15630187 A JP15630187 A JP 15630187A JP S643170 A JPS643170 A JP S643170A
- Authority
- JP
- Japan
- Prior art keywords
- grignard reagent
- pyridyl
- aldehyde
- ketone
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain a variety of pyridine derivatives by forming a pyridyl Grignard reagent from 2-, 3-, or 4-iodopyridine and a Grignard reagent and allowing the pyridyl Grignard reagent to reach with a ketone, aldehyde or ester.
CONSTITUTION: A pyridyl Grignard reagent is formed from 2-, 3-. or 4- iodopyridine and a Grignard reagent of the formula: RMgX (R is alkyl, alkenyl; X is halogen) and the pyridyl Grignard reagent is allowed to react with a ketone, aldehyde (containing α,β-unsaturated ketone or aldehyde) or ester to effect the addition of the pyridyl group to the ketone or aldehyde group or conjugated double bonds to give a pyridine derivative such as phenyl-2-pyridylcarbinol, the compound of formula I or formula II.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62156301A JP2583061B2 (en) | 1987-06-23 | 1987-06-23 | Novel production method of pyridine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62156301A JP2583061B2 (en) | 1987-06-23 | 1987-06-23 | Novel production method of pyridine derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
JPS643170A true JPS643170A (en) | 1989-01-06 |
JPH013170A JPH013170A (en) | 1989-01-06 |
JP2583061B2 JP2583061B2 (en) | 1997-02-19 |
Family
ID=15624818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62156301A Expired - Lifetime JP2583061B2 (en) | 1987-06-23 | 1987-06-23 | Novel production method of pyridine derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2583061B2 (en) |
-
1987
- 1987-06-23 JP JP62156301A patent/JP2583061B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2583061B2 (en) | 1997-02-19 |
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