JPS6416750A - Ucn-1028c and production thereof - Google Patents
Ucn-1028c and production thereofInfo
- Publication number
- JPS6416750A JPS6416750A JP17198887A JP17198887A JPS6416750A JP S6416750 A JPS6416750 A JP S6416750A JP 17198887 A JP17198887 A JP 17198887A JP 17198887 A JP17198887 A JP 17198887A JP S6416750 A JPS6416750 A JP S6416750A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- acetone
- column
- ucn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound expressed by the formula. USE:An antitumor agent of carcinogenesis inhibiting agent having antitumor activity and protein kinase C inhibiting activity. PREPARATION:UCN-1028C producing bacterium strain belonging to the genus Cladosporium is subjected to liquid cultivation in a culture medium containing a carbon source, nitrogen source, etc., at 20-35 deg.C and pH 4-10 for 1-7 days. Then the culture liquid is filtered to afford bacterium cell, which is extracted with acetone, etc. and purified by applying the extract to a nonionic porous resin column, silica gel column or Sephadex column to provide the compound expressed by the formula. Properties of the compound expressed by the formula; molecular formula, C44H38O14; molecular weight, 790; solubility, insoluble in water, soluble in alkali water, chloroform, acetone, ethyl acetate and readily soluble in methanol and DMSO.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17198887A JPH0627103B2 (en) | 1987-07-09 | 1987-07-09 | New substance UCN-1028C |
DE8888302520T DE3881566T2 (en) | 1987-03-26 | 1988-03-22 | ANTITUMOR DERIVATIVES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT. |
EP88302520A EP0284358B1 (en) | 1987-03-26 | 1988-03-22 | Novel anti-tumor compounds, method for the preparation thereof, and pharmaceutical preparations containing them |
US07/173,174 US4992570A (en) | 1987-03-26 | 1988-03-24 | UCN-1028A and UCN-1028C and process for the production thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17198887A JPH0627103B2 (en) | 1987-07-09 | 1987-07-09 | New substance UCN-1028C |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6416750A true JPS6416750A (en) | 1989-01-20 |
JPH0627103B2 JPH0627103B2 (en) | 1994-04-13 |
Family
ID=15933451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17198887A Expired - Lifetime JPH0627103B2 (en) | 1987-03-26 | 1987-07-09 | New substance UCN-1028C |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0627103B2 (en) |
-
1987
- 1987-07-09 JP JP17198887A patent/JPH0627103B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0627103B2 (en) | 1994-04-13 |
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