JPS6416750A - Ucn-1028c and production thereof - Google Patents

Ucn-1028c and production thereof

Info

Publication number
JPS6416750A
JPS6416750A JP17198887A JP17198887A JPS6416750A JP S6416750 A JPS6416750 A JP S6416750A JP 17198887 A JP17198887 A JP 17198887A JP 17198887 A JP17198887 A JP 17198887A JP S6416750 A JPS6416750 A JP S6416750A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
acetone
column
ucn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17198887A
Other languages
Japanese (ja)
Other versions
JPH0627103B2 (en
Inventor
Hirofumi Nakano
Eiji Kobayashi
Isami Takahashi
Katsuhiko Ando
Takao Iida
Shiro Akinaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP17198887A priority Critical patent/JPH0627103B2/en
Priority to DE8888302520T priority patent/DE3881566T2/en
Priority to EP88302520A priority patent/EP0284358B1/en
Priority to US07/173,174 priority patent/US4992570A/en
Publication of JPS6416750A publication Critical patent/JPS6416750A/en
Publication of JPH0627103B2 publication Critical patent/JPH0627103B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound expressed by the formula. USE:An antitumor agent of carcinogenesis inhibiting agent having antitumor activity and protein kinase C inhibiting activity. PREPARATION:UCN-1028C producing bacterium strain belonging to the genus Cladosporium is subjected to liquid cultivation in a culture medium containing a carbon source, nitrogen source, etc., at 20-35 deg.C and pH 4-10 for 1-7 days. Then the culture liquid is filtered to afford bacterium cell, which is extracted with acetone, etc. and purified by applying the extract to a nonionic porous resin column, silica gel column or Sephadex column to provide the compound expressed by the formula. Properties of the compound expressed by the formula; molecular formula, C44H38O14; molecular weight, 790; solubility, insoluble in water, soluble in alkali water, chloroform, acetone, ethyl acetate and readily soluble in methanol and DMSO.
JP17198887A 1987-03-26 1987-07-09 New substance UCN-1028C Expired - Lifetime JPH0627103B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP17198887A JPH0627103B2 (en) 1987-07-09 1987-07-09 New substance UCN-1028C
DE8888302520T DE3881566T2 (en) 1987-03-26 1988-03-22 ANTITUMOR DERIVATIVES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
EP88302520A EP0284358B1 (en) 1987-03-26 1988-03-22 Novel anti-tumor compounds, method for the preparation thereof, and pharmaceutical preparations containing them
US07/173,174 US4992570A (en) 1987-03-26 1988-03-24 UCN-1028A and UCN-1028C and process for the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17198887A JPH0627103B2 (en) 1987-07-09 1987-07-09 New substance UCN-1028C

Publications (2)

Publication Number Publication Date
JPS6416750A true JPS6416750A (en) 1989-01-20
JPH0627103B2 JPH0627103B2 (en) 1994-04-13

Family

ID=15933451

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17198887A Expired - Lifetime JPH0627103B2 (en) 1987-03-26 1987-07-09 New substance UCN-1028C

Country Status (1)

Country Link
JP (1) JPH0627103B2 (en)

Also Published As

Publication number Publication date
JPH0627103B2 (en) 1994-04-13

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