JPS638550A - Pressure sensor with comparison electrode - Google Patents
Pressure sensor with comparison electrodeInfo
- Publication number
- JPS638550A JPS638550A JP61151651A JP15165186A JPS638550A JP S638550 A JPS638550 A JP S638550A JP 61151651 A JP61151651 A JP 61151651A JP 15165186 A JP15165186 A JP 15165186A JP S638550 A JPS638550 A JP S638550A
- Authority
- JP
- Japan
- Prior art keywords
- comparison
- comparison electrode
- electrode
- liquid junction
- suction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 44
- 238000005070 sampling Methods 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 4
- 230000005489 elastic deformation Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract 1
- 239000007779 soft material Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 description 12
- 238000005259 measurement Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
［発明の目的１
（産業上の利用分野）
本発明は例えば自動化学分析装置等に使用され、被検液
の成分を分析する際に上記装置のサンプリング時の被検
液の″つまり″等を検出する比較電極による圧力検出セ
ンサに関する。DETAILED DESCRIPTION OF THE INVENTION [Objective of the Invention 1 (Industrial Field of Application) The present invention is used, for example, in an automatic chemical analyzer, etc. when analyzing the components of a test liquid. The present invention relates to a pressure detection sensor using a comparison electrode that detects "clogging" of liquid, etc.
（従来の技術）
従来、被検液例えば血液、血清、尿中に含まれる特定成
分のイオン温度を検出する自動電解質分析装置等におい
ては、被検液の測定にイオン選択性電極を使用している
。このイオン選択性電極は被検液内に含まれる特定イオ
ンの起電力を比較電極及び指示電極とで測定することに
より該イオン濃度を測定するものである。このような被
検液に含まれるイオン濃度を自動的に測定する際に問題
となるのは、°′つまり゛、°゛空吸いパが測定中に発
生することである。つまり、前者はイオン温度を測定す
べく所定容器内に収納されている被検液の種類、例えば
分離されていない血液等が流路中で固化する場合等であ
る。一方接者は、測定中に被検液が何らかの原因により
吸引されずに測定されることである。この為に収集する
データに誤差を生じさせてしまう事があるということで
ある。(Prior Art) Conventionally, in automatic electrolyte analyzers that detect the ion temperature of specific components contained in test fluids such as blood, serum, and urine, ion-selective electrodes have been used to measure the test fluid. There is. This ion-selective electrode measures the ion concentration by measuring the electromotive force of specific ions contained in the test liquid using a reference electrode and an indicator electrode. A problem that arises when automatically measuring the concentration of ions contained in such a test liquid is the occurrence of empty suction during the measurement. That is, the former case is a case where the type of test liquid stored in a predetermined container for measuring the ion temperature, such as unseparated blood, solidifies in the flow path. On the other hand, in contact, the test liquid is measured without being aspirated for some reason during the measurement. This means that errors may occur in the data collected.
従来上記問題が発生した際には、何らの対策も講じられ
ていなかった。Conventionally, when the above problem occurred, no countermeasures were taken.
（発明が解決しようとする問題点）
上記したように従来の自動化学分析装置においては、測
定中に′°つまり°′、′°空吸い″突成生することで
ある。つまり、前者は被検液中の成分濃度を測定すべく
所定容器内に収納されている被検液の種類、例えば分離
されていない血液等が流路中で固化する場合である。一
方後者は、測定中に被検液が何らかの原因により吸引さ
れずに測定されることである。この為に収集するデータ
に誤差を生じざぜてしまう事があるということが問題で
ｄう つ ｌご。(Problems to be Solved by the Invention) As mentioned above, in the conventional automatic chemical analyzer, '°', '°', and '°dry suction' suddenly occur during measurement.In other words, the former is subject to This is a case where the type of test liquid stored in a predetermined container to measure the component concentration in the test liquid, such as unseparated blood, solidifies in the flow path. The problem is that the test liquid is not aspirated for some reason and is measured.This can cause errors in the collected data, which is a problem.
［発明の構成１
（問題点を解決するための手段）
上記問題点を解決するための本発明の構成は、被検液を
吸引吐出するサンプリングノズルの流路に液絡部材を介
して接するように配置された比較電極において、少なく
とも比較電極を流路に沿って２つ以上設け、一方の比較
電極の液絡部材を柔軟性部材、他方の比較電極の液絡部
材を剛性部材で形成し、上記流路での吸引吐出圧力を測
定するようにした。[Configuration 1 of the Invention (Means for Solving the Problems) The configuration of the present invention for solving the above-mentioned problems is to contact the flow path of the sampling nozzle that sucks and discharges the test liquid through a liquid junction member. In the comparison electrode arranged in the flow path, at least two or more comparison electrodes are provided along the flow path, the liquid junction member of one comparison electrode is formed of a flexible member, and the liquid junction member of the other comparison electrode is formed of a rigid member, The suction and discharge pressure in the flow path was measured.
（作 用）
上記構成を有する本発明の作用は、被検液を測定づるサ
ンプリング部に例えば２個の比較電極を設けて、一方の
電極の液絡部材を柔軟性部材で形成して被検液の吸引吐
出時の圧力変動を検出させ、他方の電極の液絡部材を剛
性部材で構成して、両者の電位差から測定時での被検液
の″つまり′。(Function) The function of the present invention having the above-mentioned configuration is that, for example, two reference electrodes are provided in the sampling section for measuring the test liquid, and the liquid junction member of one of the electrodes is formed of a flexible member. The pressure fluctuations during suction and discharge of the liquid are detected, and the liquid junction member of the other electrode is made of a rigid member, and the potential difference between the two is used to determine whether the sample liquid is clogged during measurement.
゛突成いパの有無を検出ざぜている。このようにして被
検液測定時の被検液の″つまりＩＴ 、ＩＴ空突成パ等
を検出できるようにしている。``The presence or absence of sudden growth is being detected. In this way, it is possible to detect "IT", IT void formation, etc. of the test liquid during measurement of the test liquid.
（実施例）
以下、本発明を利用した自動化学分析装置特に・被検液
を吸引して測定するサンプリング部の一実施例について
図面を参照して説明する。(Example) Hereinafter, an example of an automatic chemical analyzer using the present invention, particularly a sampling section that aspirates and measures a test liquid, will be described with reference to the drawings.
第２図において自動化学分析装置のサンプリング部は、
所定容器４内に収納されている被検液例えば血液（図中
斜線で示す）を吸引するサンプリングノズル３と、この
サンプリングノズル３から吸引された被検液の吸引吐出
圧力を電位差として測定する第１の比較電極１と、第２
の比較電極１０とが被検液の流路たるサンプリングチュ
ーブ２に沿って２個設けられている。そして、このサン
プリングチューブ２の後段には吸引ポンプ５が設けられ
ており、この吸引ポンプ５により所定容器４内の被検液
の吸引あるいは吐出を行うようになっている。In Figure 2, the sampling section of the automatic chemical analyzer is
A sampling nozzle 3 that sucks a sample liquid, such as blood (indicated by diagonal lines in the figure), stored in a predetermined container 4, and a nozzle that measures the suction and discharge pressure of the sample liquid sucked from the sampling nozzle 3 as a potential difference. 1 comparison electrode 1 and a second comparison electrode 1
Two comparison electrodes 10 are provided along the sampling tube 2, which is a flow path for the test liquid. A suction pump 5 is provided downstream of the sampling tube 2, and the suction pump 5 suctions or discharges the test liquid in a predetermined container 4.
第１図は前記第２図に示す比較電極１，１０を拡大した
断面図でおる。FIG. 1 is an enlarged sectional view of the comparison electrodes 1 and 10 shown in FIG. 2. As shown in FIG.
同図において比較電極１．１０は、サンプリングチュー
ブ２の肉厚とほぼ同寸法の円筒状からなる液絡部材それ
ぞれ１ａ、１０ａと、この液絡部＋Ｊ１ａ、１０ａを中
心としてこの液絡部材の外周に設けた中空かつ円筒状の
絶縁部材それぞれ１ｂ。In the same figure, the reference electrode 1.10 includes cylindrical liquid junction members 1a and 10a having approximately the same dimensions as the wall thickness of the sampling tube 2, and the outer periphery of this liquid junction member around the liquid junction parts +J1a and 10a. Hollow and cylindrical insulating members 1b provided in each.
１０ｂと、この絶縁部材と液絡部材とで形成される中空
部分に電解質溶液例えば塩化カリウムとが満たされた構
成となっている。そして、測定された電位は上記電解質
溶液に接するように設けられたケーブルＡ、Ｂを介して
後段に設けられている図示しない処理装置により演算処
理されるようになっている。この処理装置において、上
記２つの比較電極で測定された電位の差つまり電位差を
測定するようにしている。10b, the insulating member, and the liquid junction member, the hollow portion is filled with an electrolyte solution such as potassium chloride. The measured potential is then processed by a processing device (not shown) provided at a subsequent stage via cables A and B provided in contact with the electrolyte solution. In this processing device, the difference between the potentials measured by the two comparison electrodes, that is, the potential difference is measured.
上記構成を有する２つの比較電極１．１０の相違点は、
液絡部材１ａ、”＋ｏａがそれぞれ柔軟性部材と剛性部
材とから構成されていることである。The difference between the two comparison electrodes 1.10 having the above configuration is as follows:
Each of the liquid junction members 1a and ``+oa'' is composed of a flexible member and a rigid member.
第１のイオン選択性電極１の液絡部材１ａは柔軟性部材
例えばポリビニールクロライドで形成され、他方、第２
のイオン選択性電極１の液絡部材１０ａは剛性部材例え
ばセラミックから構成されている。The liquid junction member 1a of the first ion-selective electrode 1 is made of a flexible material, for example polyvinyl chloride, while the second
The liquid junction member 10a of the ion-selective electrode 1 is made of a rigid member such as ceramic.
従って、液絡部材を柔軟性部材で形成した第１の比較電
極１は、例えば流路たるサンプリングデユープ２が何ら
かの原因によって″つまり″を生じた場合には、吸引ポ
ンプにより発生ずる負の圧力により液絡部材が弾性変型
するようになり、その弾性変型に伴って電位が変動する
。一方、゛°空吸い″の場合にはまったく電位の変動が
ない。このようにして、第２の比較電極の電位と比較演
算することで゛つまり７９ 、 Ｉ！空突成パの発生を
検出するようにしている。このようなフロースルー型の
比較電極を圧力センサとして用いたので、装置自体の小
形化を図ることができる。また、直接圧力変動を電位差
として検出するので、測定誤差が少ないという効果をも
得ることができる。Therefore, the first comparison electrode 1 whose liquid junction member is made of a flexible material can absorb the negative energy generated by the suction pump if, for example, the sampling duplex 2, which is a flow path, becomes "clogged" for some reason. The pressure causes the liquid junction member to undergo elastic deformation, and the potential changes along with the elastic deformation. On the other hand, in the case of ``dry suction'', there is no change in the potential at all.In this way, by performing a comparison calculation with the potential of the second comparison electrode, the occurrence of ``79, I! By using such a flow-through type reference electrode as a pressure sensor, the device itself can be made more compact.Also, since pressure fluctuations are directly detected as potential differences, there are fewer measurement errors. This effect can also be obtained.
この関係は第３図に示すように一対一の関係が成立する
ことが判明している。すなわち、所定電位に達すればパ
つまりパが発生していることを示し、電位が生じなけれ
ば″突成いパであることが分る。このようにして、比較
電極を用いてサンプリング部での被検液の″つまりＩＴ
、 Ｉｆ空突成パの発生を検出することが可能となる
。It has been found that this relationship is a one-to-one relationship as shown in FIG. In other words, if a predetermined potential is reached, it indicates that a puddle is occurring, and if no potential is generated, it is determined that a "sudden pap" has occurred. ``IT'' of the test liquid
, It becomes possible to detect the occurrence of an If empty bulge formation.
尚、本発明は上記実施例に限定されず本発明の要旨の範
囲内で様々に変型実施が可能である。Note that the present invention is not limited to the above-mentioned embodiments, and various modifications can be made within the scope of the gist of the present invention.
例えば上述したように比較電極だけを単独で用いる他に
、イオン選択性電極に設けられているイオン電極を利用
し、被検液に含まれるイオン濃度を測定しつつ同時に上
記吸引吐出圧力を測定するようにしてもよい。このにう
にすることで、吸引吐出圧力を測定するために、他の圧
力センサを設ける必要がなく、例えば自動化学分析装置
自体のコストダウンを図ることができる。For example, in addition to using the reference electrode alone as described above, the ion electrode provided on the ion-selective electrode can be used to measure the ion concentration contained in the test liquid and at the same time measure the suction and discharge pressure. You can do it like this. By doing this, there is no need to provide another pressure sensor to measure the suction and discharge pressure, and for example, the cost of the automatic chemical analyzer itself can be reduced.
［発明の効果］
以上詳述したように本発明によれば、所定経路でのパつ
まり′°を検出できる比較電極による圧力検出センサの
提供ができる。[Effects of the Invention] As described in detail above, according to the present invention, it is possible to provide a pressure detection sensor using a comparison electrode that can detect a blockage in a predetermined path.
第１図は比較電極の拡大断面図、第２図は自動化学分析
装置のサンプリング部の説明図、第３図は電位差と圧力
との関係図である。
１．１０・・・比較電極、３・・・サンプリングノズル
、１ａ、１０ａ・・・液絡部材。
代理人 弁理士 則 近 憲 缶周
大 胡 典 大箱２図
第３図FIG. 1 is an enlarged sectional view of a reference electrode, FIG. 2 is an explanatory diagram of a sampling section of an automatic chemical analyzer, and FIG. 3 is a diagram of the relationship between potential difference and pressure. 1.10... Reference electrode, 3... Sampling nozzle, 1a, 10a... Liquid junction member. Agent Patent Attorney Nori Chika Ken Shu
Ogo Nen Large Box Figure 2 Figure 3
Claims (3)
に液絡部材を介して接するように配置された比較電極に
おいて、少なくとも比較電極を流路に沿つて２つ以上設
け、一方の比較電極の液絡部材を柔軟性部材、他方の比
較電極の液絡部材を剛性部材で形成し、上記流路での吸
引吐出圧力を測定するようにしたことを特徴とする比較
電極による圧力検出センサ。(1) In a comparison electrode arranged so as to be in contact with a flow path of a sampling nozzle that sucks and discharges a test liquid through a liquid junction member, at least two or more comparison electrodes are provided along the flow path, and one reference electrode A pressure detection sensor using a comparison electrode, characterized in that the liquid junction member of the second comparison electrode is formed of a flexible member, and the liquid junction member of the other comparison electrode is formed of a rigid member, and the suction and discharge pressure in the flow path is measured.
特許請求の範囲第１項記載の比較電極による圧力検出セ
ンサ。(2) A pressure detection sensor using a reference electrode according to claim 1, wherein the flexible member is polyvinyl chloride.
第１項記載の比較電極による圧力検出センサ。(3) A pressure detection sensor using a comparison electrode according to claim 1, wherein the rigid member is made of ceramic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61151651A JPS638550A (en) | 1986-06-30 | 1986-06-30 | Pressure sensor with comparison electrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61151651A JPS638550A (en) | 1986-06-30 | 1986-06-30 | Pressure sensor with comparison electrode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS638550A true JPS638550A (en) | 1988-01-14 |
Family
ID=15523228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61151651A Pending JPS638550A (en) | 1986-06-30 | 1986-06-30 | Pressure sensor with comparison electrode |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS638550A (en) |
-
1986
- 1986-06-30 JP JP61151651A patent/JPS638550A/en active Pending
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