JPH0121467B2 - - Google Patents
Info
- Publication number
- JPH0121467B2 JPH0121467B2 JP55067876A JP6787680A JPH0121467B2 JP H0121467 B2 JPH0121467 B2 JP H0121467B2 JP 55067876 A JP55067876 A JP 55067876A JP 6787680 A JP6787680 A JP 6787680A JP H0121467 B2 JPH0121467 B2 JP H0121467B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- liquid level
- suction cylinder
- suction
- nozzle tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 claims description 30
- 238000001514 detection method Methods 0.000 claims description 28
- 238000000034 method Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
Description
【発明の詳細な説明】
本発明は自動分注装置、特に分注される試料の
液面を検知可能な自動分注装置の改良に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic dispensing device, and more particularly to an improvement in an automatic dispensing device capable of detecting the liquid level of a sample to be dispensed.
検体検査においては、所望量の試料を吸入採取
する分注が不可欠であり、通常の場合吸引ポンプ
に連接されたノズルチツプを試料中に挿入して所
定量の試料を吸入採取する装置が用いられてい
る。近年の分注装置は各分注工程が自動的に行わ
れ、多種類の試料を短時間で処理するために好適
である。 In laboratory tests, it is essential to dispense a desired amount of sample by inhalation, and normally a device is used that inserts a nozzle tip connected to a suction pump into the sample to collect a predetermined amount of sample by inhalation. There is. Recent dispensing apparatuses perform each dispensing process automatically and are suitable for processing many types of samples in a short time.
通常の場合、分注される試料としては血清ある
いは血漿等の生体からの採取試料が用いられ、分
注された試料が試薬その他と混合されて所定の検
体検査が行われる。前述したように、通常の分注
試料は被検者から直接採血した試料等から成るの
で、その採血量あるいは血液の分離程度の相違に
より分注される試料はそれ自体その量が著しく相
違する。従来の自動分注装置は単にそのノズルチ
ツプを試料中に挿入して吸引ポンプを所定の吸引
量だけ作動させることにより試料の吸入採取を行
うが、この吸入作用は試料の量にかかわらず常に
一定の吸入作用として行われるので、必要量に満
たない試料の場合、ノズルチツプからは空気が吸
入され、この結果、分注精度が著しく低下すると
いう欠点があつた。したがつて、従来の自動分注
装置では、使用者が予め試料容器内の試料の量そ
の他を確認しなければならないという欠点があつ
た。 In normal cases, a sample collected from a living body, such as serum or plasma, is used as the sample to be dispensed, and the dispensed sample is mixed with reagents and other substances to perform a predetermined specimen test. As mentioned above, a typical dispensed sample consists of a blood sample directly collected from a subject, and therefore, the amount of the sample to be dispensed varies significantly depending on the amount of blood collected or the degree of separation of the blood. Conventional automatic dispensing devices simply insert the nozzle tip into the sample and operate the suction pump for a predetermined amount of suction to collect the sample, but this suction action is always constant regardless of the amount of sample. Since this is performed as an inhalation action, if the amount of sample is less than the required amount, air will be inhaled from the nozzle tip, resulting in a disadvantage that the dispensing accuracy will be significantly reduced. Therefore, the conventional automatic dispensing device has a disadvantage in that the user must confirm the amount of sample in the sample container and other details in advance.
前述したように、従来装置では、少量試料から
の分注を可能とするために、試料吸入用ノズルチ
ツプは試料容器の底部まで挿入されて試料の採取
が行われている。しかしながら、この方式では、
一方において容器内に多量の試料が収納されてい
る場合に、ノズルチツプの内周面および外周面が
試料により著しく汚染され、ノズルチツプをこの
まま次の試料採取に使用すると、ノズルチツプに
付着した試料が次の検体に混入（クロスコンタミ
ネーシヨン）し、試料の分析結果に著しい誤差が
生じるという問題があつた。従来装置では、この
ような検体間のクロスコンタミネーシヨンによる
悪影響を除去するために、各吸入採取の都度ノズ
ルチツプを洗浄する方式が用いられ、このために
洗浄液による洗浄、紙による拭き取り、あるい
は真空吸引による付着試料の吸い取り等が実用化
されている。しかしながら、この洗浄方式では、
分注作業に時間がかかり、また完全にノズルチツ
プを洗浄することが不可能であるとともに、洗浄
のための特殊な装置あるいは紙等の消耗品を必
要とするという欠点があつた。 As described above, in the conventional apparatus, in order to enable dispensing from a small amount of sample, the sample suction nozzle tip is inserted to the bottom of the sample container to collect the sample. However, with this method,
On the other hand, if a large amount of sample is stored in the container, the inner and outer circumferential surfaces of the nozzle tip will be significantly contaminated by the sample, and if the nozzle tip is used as is for the next sample collection, the sample attached to the nozzle tip will be transferred to the next sample. There was a problem in that the sample was mixed with the sample (cross-contamination), causing a significant error in the sample analysis results. In conventional devices, in order to eliminate the adverse effects of cross-contamination between samples, a method is used in which the nozzle tip is cleaned after each inhalation collection, and for this purpose, cleaning with cleaning liquid, wiping with paper, or vacuum suction It has been put into practical use to absorb adhered samples using the method. However, with this cleaning method,
Dispensing operations take a long time, it is impossible to completely clean the nozzle tip, and special equipment or consumables such as paper are required for cleaning.
本発明は上記従来の課題に鑑みなされたもの
で、その目的は容器内の試料の量にかかわらず常
に一定の吸入採取を行い、かつノズルチツプの先
端を試料内の最適位置に保つために試料の液面を
検知することのできる改良された自動分注装置を
提供することにある。 The present invention was developed in view of the above-mentioned conventional problems, and its purpose is to always perform constant suction collection regardless of the amount of sample in the container, and to maintain the tip of the nozzle tip at the optimal position within the sample. An object of the present invention is to provide an improved automatic dispensing device capable of detecting liquid level.
上記目的を達成するために、本発明は吸引ポン
プに連接されたノズルチツプを試料中に挿入して
所定量の試料を吸入採取する自動分注装置におい
て、前記ノズルチツプに接続された吸入シリンダ
と、該吸入シリンダに一端が連通接続され他端が
大気に開口した開放路と、前記吸入シリンダ及び
開放路に同一の液面検知負圧を与える検知圧供給
装置と、吸入シリンダ及び開放路の内圧を検出し
ノズルチツプの試料液面への接触により前記両内
圧に所定値以上の差圧が生じたときに液面検知信
号を出力する差圧検出部と、吸入シリンダに設け
られ試料液面検知前は吸入シリンダを前記検知圧
供給装置に接続し前記差圧検出部から液面検知信
号が出力されたときに吸入シリンダを前記吸入ポ
ンプに切換え接続する切換弁と、を含むことを特
徴とする。 In order to achieve the above object, the present invention provides an automatic dispensing device that sucks and collects a predetermined amount of sample by inserting a nozzle tip connected to a suction pump into a sample. an open path with one end connected to the suction cylinder and the other end open to the atmosphere, a detection pressure supply device that applies the same liquid level detection negative pressure to the suction cylinder and the open path, and detects the internal pressure of the suction cylinder and the open path. A differential pressure detection part that outputs a liquid level detection signal when a pressure difference of more than a predetermined value is generated between the two internal pressures due to contact of the nozzle tip with the sample liquid level, and a differential pressure detection part that outputs a liquid level detection signal when the nozzle tip contacts the sample liquid level, and The present invention is characterized in that it includes a switching valve that connects the cylinder to the detection pressure supply device and switches and connects the suction cylinder to the suction pump when a liquid level detection signal is output from the differential pressure detection section.
以下図面に基づいて本発明の好適な実施例を説
明する。 Preferred embodiments of the present invention will be described below based on the drawings.
第１図には、本発明に係る自動分注装置の好適
な実施例が示され、容器１０内に収納された血清
等の試料１２は吸入シリンダ１４の先端に設けら
れたノズルチツプ１６から吸入シリンダ１４内に
吸入採取される。本発明において特徴的なことは
自動分注装置に試料液面検知装置が設けられてい
ることであり、ノズルチツプ１６の吸入初期位置
が液面検知信号に基づいて制御される。 FIG. 1 shows a preferred embodiment of the automatic dispensing device according to the present invention, in which a sample 12 such as serum stored in a container 10 is delivered to the suction cylinder from a nozzle tip 16 provided at the tip of the suction cylinder 14. The sample is taken by inhalation within 14 days. A feature of the present invention is that the automatic dispensing device is provided with a sample liquid level detection device, and the initial suction position of the nozzle tip 16 is controlled based on the liquid level detection signal.
本発明における試料液面検知装置は前述した吸
入シリンダ１４と、この吸入シリンダ１４に連通
された開放路１８と、を含み、開放路１８はその
一端１８ａにて大気へ開口している。開放路１８
は吸入シリンダ１４とほぼ同一の形状すなわちそ
の直径あるいは長さが同一に設定され、両者の流
路抵抗が等しく形成されている。吸入シリンダ１
４と開放路１８とはその端部が導管２０に接続さ
れ、導管２０は検知圧供給装置２２に接続されて
いる。実施例において、検知圧供給装置２２は圧
力調整器付吸引ポンプから成り、吸入シリンダ１
４および開放路１８に同一の液面検知負圧を与え
る。 The sample liquid level detection device according to the present invention includes the above-described suction cylinder 14 and an open passage 18 communicating with the suction cylinder 14, and the open passage 18 opens to the atmosphere at one end 18a. open road 18
is set to have almost the same shape as the suction cylinder 14, that is, its diameter or length, and the flow path resistance of both is made equal. Suction cylinder 1
4 and the open channel 18 are connected at their ends to a conduit 20, and the conduit 20 is connected to a sensing pressure supply device 22. In the embodiment, the detection pressure supply device 22 consists of a suction pump with a pressure regulator, and the suction cylinder 1
4 and the open path 18 are given the same liquid level detection negative pressure.
実施例において、吸入シリンダ１４には切換弁
として電磁弁から成る三方弁２４が設けられ、三
方弁２４はその各弁口が吸入シリンダ１４、導管
２０そして試料を吸入採取するための吸入ポンプ
２６に接続されている。 In the embodiment, the suction cylinder 14 is provided with a three-way valve 24 consisting of a solenoid valve as a switching valve, the three-way valve 24 having its respective valve opening connected to the suction cylinder 14, the conduit 20 and the suction pump 26 for suctioning and collecting the sample. It is connected.
吸入シリンダ１４と開放路１８との間には、液
面検知信号を出力する差圧検出部が設けられてい
る。すなわち、両者の差圧を検出する差圧検出器
２８が設けられ、この差圧信号が増幅器３０を介
して信号判別器３２へ供給され、信号判別器３２
から液面検知信号が出力される。 A differential pressure detection section is provided between the suction cylinder 14 and the open passage 18 to output a liquid level detection signal. That is, a differential pressure detector 28 is provided to detect the differential pressure between the two, and this differential pressure signal is supplied to the signal discriminator 32 via the amplifier 30.
A liquid level detection signal is output from.
本発明の実施例は以上の構成から成り、以下に
その作用を説明する。 The embodiment of the present invention has the above configuration, and its operation will be explained below.
第１図は三方弁２４が導管２０側へ切り換えら
れた状態を示し、検知圧供給装置２２から供給さ
れる負圧は吸入シリンダ１４および開放路１８へ
均一に与えられる。このとき、吸入シリンダ１４
と開放路１８とは同一の流路抵抗を有するので、
差圧検出器２８からの差圧信号はほぼ０となる。 FIG. 1 shows a state in which the three-way valve 24 is switched to the conduit 20 side, and the negative pressure supplied from the detection pressure supply device 22 is uniformly applied to the suction cylinder 14 and the open passage 18. At this time, the suction cylinder 14
and the open channel 18 have the same flow resistance, so
The differential pressure signal from the differential pressure detector 28 is approximately zero.
この状態で、吸入シリンダ１４は周知の自動分
注制御作用により、自動的に容器１０の試料１２
へ向かつて下降する。そして、吸入シリンダ１４
のノズルチツプ１６が試料１２の液面に接触する
と、ノズルチツプ１６部において吸入シリンダ１
４は閉塞され、この結果、吸入シリンダ１４と開
放路１８との間には立上がりの急峻な差圧が発生
することとなる。この差圧は差圧検出器２８によ
り電気的に検出され、更に増幅器３０にて増幅さ
れた後、信号判別器３２において所定の基準値と
比較され、誤差信号その他が除去されてノズルチ
ツプ１６が試料１２の液面と接触した状態を正確
に液面検知信号として出力する。このとき開放路
１８の開口端１８ａは大気に開口された状態が維
持されているので、吸入シリンダ１４が接触した
試料１２を吸い上げることはない。 In this state, the suction cylinder 14 automatically removes the sample 12 from the container 10 by a well-known automatic dispensing control function.
It descends towards the end. And the suction cylinder 14
When the nozzle tip 16 contacts the liquid surface of the sample 12, the suction cylinder 1
4 is closed, and as a result, a steeply rising differential pressure is generated between the suction cylinder 14 and the open passage 18. This differential pressure is electrically detected by a differential pressure detector 28, further amplified by an amplifier 30, and then compared with a predetermined reference value by a signal discriminator 32, and error signals and other signals are removed. The state of contact with the liquid level of No. 12 is accurately output as a liquid level detection signal. At this time, since the open end 18a of the open channel 18 is maintained open to the atmosphere, the sample 12 that the suction cylinder 14 comes in contact with is not sucked up.
前記液面検出信号は図示しない制御装置に供給
され、予め入力されている容器１０の大きさと検
知された液面とを演算して試料１２の量が求めら
れ、所定の採取量を満足するか否かの比較判定が
行われ、試料１２が所望量に満たない場合には試
料１２の注入採取を行うことなく、また必要に応
じて表示パネルに試料不足の表示を行う。 The liquid level detection signal is supplied to a control device (not shown), and the amount of the sample 12 is determined by calculating the size of the container 10 input in advance and the detected liquid level, and whether the sample 12 satisfies a predetermined sampling amount or not. A comparative determination is made as to whether or not the sample 12 is present in the desired amount, and if the sample 12 is less than the desired amount, the sample 12 is not injected and collected, and if necessary, a display panel displays a message indicating that the sample is insufficient.
試料１２の量が注入採取に十分である場合、自
動分注装置は分注作用を開始し、このために、ノ
ズルチツプ１６は試料１２内への挿入量および吸
入速度に対応したノズルチツプ１６の移動量が設
定され、これとともに、三方弁２４は吸入シリン
ダ１４と吸入ポンプ２６とを歴接するように切換
制御される。 If the amount of sample 12 is sufficient for injection collection, the automatic dispensing device starts the dispensing action, for which the nozzle tip 16 moves an amount corresponding to the insertion amount into the sample 12 and the suction speed. is set, and at the same time, the three-way valve 24 is controlled to switch so that the suction cylinder 14 and the suction pump 26 are in contact with each other.
試料１２が所定量吸入シリンダ１４内へ吸入採
取されると、吸入シリンダ１４は周知のようにこ
の吸入した試料を分注容器へ排出し、再び吸入シ
リンダ１４は次の吸入試料へ向かつて移動制御さ
れる。 When a predetermined amount of the sample 12 is collected by suction into the suction cylinder 14, the suction cylinder 14 discharges the aspirated sample into a dispensing container, as is well known, and the suction cylinder 14 moves to the next suction sample. be done.
本発明によれば、試料１２の液面を正確に検出
することができるので、試料吸入時におけるノズ
ルチツプ１６の先端位置も自由に制御することが
でき、例えば第２図に示されるように、100μ
程度の採取量の場合、ノズルチツプ１６の先端は
約２mm程度試料１２の液中に挿入され、試料の吸
入採取中、常にこの挿入量が確保されるので、実
際上ノズルチツプ１６の外周面は液面の表面張力
により試料とほとんど接触することなく、この結
果、ノズルチツプ１６の外周面に付着する試料の
量を極めて微量に抑制することができ、多数の試
料を連続的に分注する時に検体間の混入によるク
ロスコンタミネーシヨンを防止することが可能と
なる。 According to the present invention, since the liquid level of the sample 12 can be accurately detected, the position of the tip of the nozzle tip 16 when sucking the sample can be freely controlled. For example, as shown in FIG.
In the case of a sampling amount of approximately 2 mm, the tip of the nozzle tip 16 is inserted into the liquid of the sample 12 by approximately 2 mm, and this amount of insertion is always ensured during the suction collection of the sample. As a result, the amount of sample adhering to the outer surface of the nozzle tip 16 can be suppressed to an extremely small amount due to the surface tension of the nozzle tip. It becomes possible to prevent cross-contamination due to mixing.
以上説明したように、本発明によれば、ノズル
チツプと試料液面との接触位置を検出して試料の
液面を正確に検知することができ、この液面検知
信号に基づいて自動分注作用を正確に制御するこ
とにより、極めて微量の試料採取が可能となり、
使用者の労力を著しく低減させることができ、ま
た正確な分注を行うことが可能となる。 As explained above, according to the present invention, the liquid level of the sample can be accurately detected by detecting the contact position between the nozzle tip and the sample liquid level, and the automatic dispensing operation can be performed based on this liquid level detection signal. By precisely controlling the
The user's labor can be significantly reduced and accurate dispensing can be performed.
第１図は本発明に係る自動分注装置の好適な実
施例を示す概略構成図、第２図は第１図における
試料吸入時のノズルチツプと試料液面との関係を
示す説明図である。
１２……試料、１４……吸入シリンダ、１６…
…ノズルチツプ、１８……開放路、２２……検知
圧供給装置、２４……三方弁、２６……吸入ポン
プ、２８……差圧検出器、３２……信号判別器。
FIG. 1 is a schematic configuration diagram showing a preferred embodiment of the automatic dispensing device according to the present invention, and FIG. 2 is an explanatory diagram showing the relationship between the nozzle tip and the sample liquid level during sample intake in FIG. 1. 12...sample, 14...suction cylinder, 16...
... Nozzle chip, 18 ... Open path, 22 ... Detection pressure supply device, 24 ... Three-way valve, 26 ... Suction pump, 28 ... Differential pressure detector, 32 ... Signal discriminator.
Claims (1)
中に挿入して所定量の試料を吸入採取する自動分
注装置において、 前記ノズルチツプに接続された吸入シリンダ
と、該吸入シリンダに一端が連通接続され他端が
大気に開口した開放路と、前記吸入シリンダ及び
開放路に同一の液面検知負圧を与える検知圧供給
装置と、吸入シリンダ及び開放路の内圧を検出し
ノズルチツプの試料液面への接触により前記両内
圧に所定値以上の差圧が生じたときに液面検知信
号を出力する差圧検出部と、吸入シリンダに設け
られ試料液面検知前は吸入シリンダを前記検知圧
供給装置に接続し前記差圧検出部から液面検知信
号が出力されたときに吸入シリンダを前記吸入ポ
ンプに切換え接続する切換弁と、 を含むことを特徴とする自動分注装置。[Scope of Claims] 1. An automatic dispensing device that sucks and collects a predetermined amount of sample by inserting a nozzle tip connected to a suction pump into a sample, comprising: a suction cylinder connected to the nozzle tip; and one end connected to the suction cylinder. an open channel with the other end open to the atmosphere; a detection pressure supply device that applies the same liquid level detection negative pressure to the suction cylinder and the open channel; a differential pressure detection section that outputs a liquid level detection signal when a pressure difference of a predetermined value or more occurs between the two internal pressures due to contact with the liquid surface; An automatic dispensing device comprising: a switching valve connected to a pressure supply device and switchingly connecting a suction cylinder to the suction pump when a liquid level detection signal is output from the differential pressure detection section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6787680A JPS56164958A (en) | 1980-05-23 | 1980-05-23 | Automatic dispenser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6787680A JPS56164958A (en) | 1980-05-23 | 1980-05-23 | Automatic dispenser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56164958A JPS56164958A (en) | 1981-12-18 |
| JPH0121467B2 true JPH0121467B2 (en) | 1989-04-21 |
Family
ID=13357547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6787680A Granted JPS56164958A (en) | 1980-05-23 | 1980-05-23 | Automatic dispenser |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56164958A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009041035A1 (en) * | 2007-09-28 | 2009-04-02 | Panasonic Corporation | Measuring method using biosensor |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1252173A (en) * | 1984-07-19 | 1989-04-04 | Thomas C. Jessop | Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid |
| US4794085A (en) * | 1984-07-19 | 1988-12-27 | Eastman Kodak Company | Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid |
| JPH076995B2 (en) * | 1985-05-15 | 1995-01-30 | 株式会社東芝 | Automatic chemical analyzer |
| JPS6264912A (en) * | 1985-09-17 | 1987-03-24 | Minoru Atake | Distributive injection apparatus |
| IT1181735B (en) * | 1985-11-19 | 1987-09-30 | Chemila Srl | LIQUID LEVEL SENSOR, USED IN AN AUTOMATIC STATION FOR THE PREPARATION OF IMMUNOLOGICAL DOSAGES |
| JPS63175864U (en) * | 1987-05-02 | 1988-11-15 | ||
| CA1321940C (en) * | 1987-05-02 | 1993-09-07 | Teruaki Itoh | Apparatus for distributing sample liquid |
| JPH0690214B2 (en) * | 1989-01-25 | 1994-11-14 | アロカ株式会社 | Liquid level detection method of automatic pipetting device |
| JPH087222B2 (en) * | 1990-01-18 | 1996-01-29 | 持田製薬株式会社 | Automatic dispensing dilution device |
| JP3049615B2 (en) * | 1992-06-08 | 2000-06-05 | ベーリング ダイアグノスティックス，インコーポレーテッド | Liquid dispensing system |
| US5665601A (en) * | 1996-01-22 | 1997-09-09 | Johnson & Johnson Clinical Diagnostics, Inc. | Avoiding bubble formation while sensing air-liquid interface using pressurized air flow |
| JPH10115620A (en) * | 1996-10-11 | 1998-05-06 | Hitachi Ltd | Clinical autoanalyzer |
| CN1653338A (en) | 2002-05-17 | 2005-08-10 | 贝克顿·迪金森公司 | Automated system for isolating, amplifying and detecting a target nucleic acid sequence |
| JP2005249585A (en) * | 2004-03-04 | 2005-09-15 | Olympus Corp | Autoanalyzer and analysis method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5513741U (en) * | 1978-07-15 | 1980-01-29 |
-
1980
- 1980-05-23 JP JP6787680A patent/JPS56164958A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5513741U (en) * | 1978-07-15 | 1980-01-29 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009041035A1 (en) * | 2007-09-28 | 2009-04-02 | Panasonic Corporation | Measuring method using biosensor |
| JP2009085695A (en) * | 2007-09-28 | 2009-04-23 | Panasonic Corp | Measuring method using biosensor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56164958A (en) | 1981-12-18 |
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