JPS6348312B2

JPS6348312B2 -

Info

Publication number: JPS6348312B2
Authority: JP; Japan
Prior art keywords: ligand; layer; reagent; element according; analytical element
Prior art date: 1981-07-06
Legal status : Expired

Application number

JP11667682A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5817365A (ja

Inventor

Uorutaa Paato

Current Assignee

Bayer Corp

Original Assignee

Miles Laboratories Inc

Priority date

1981-07-06

Filing date

1982-07-05

Publication date

1988-09-28

1982-07-05 Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc

1983-02-01 Publication of JPS5817365A publication Critical patent/JPS5817365A/ja

1988-09-28 Publication of JPS6348312B2 publication Critical patent/JPS6348312B2/ja

Status Granted legal-status Critical Current

Links

239000003153 chemical reaction reagent Substances 0.000 claims description 143
239000003446 ligand Substances 0.000 claims description 112
238000009739 binding Methods 0.000 claims description 68
230000027455 binding Effects 0.000 claims description 67
230000005855 radiation Effects 0.000 claims description 53
238000000034 method Methods 0.000 claims description 41
230000009870 specific binding Effects 0.000 claims description 39
230000004044 response Effects 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 34
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108090000790 Enzymes Proteins 0.000 claims description 33
229940088598 enzyme Drugs 0.000 claims description 33
239000007788 liquid Substances 0.000 claims description 33
238000004458 analytical method Methods 0.000 claims description 26
230000003993 interaction Effects 0.000 claims description 18
239000000126 substance Substances 0.000 claims description 17
238000001514 detection method Methods 0.000 claims description 16
238000006243 chemical reaction Methods 0.000 claims description 15
239000000049 pigment Substances 0.000 claims description 15
239000000463 material Substances 0.000 claims description 14
230000000694 effects Effects 0.000 claims description 13
239000007787 solid Substances 0.000 claims description 12
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
239000000758 substrate Substances 0.000 claims description 10
238000000159 protein binding assay Methods 0.000 claims description 8
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
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VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims description 5
235000019162 flavin adenine dinucleotide Nutrition 0.000 claims description 5
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MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical group [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
150000008064 anhydrides Chemical class 0.000 claims description 4
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical group [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 4
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