JPS6342230B2 - - Google Patents
Info
- Publication number
- JPS6342230B2 JPS6342230B2 JP54006993A JP699379A JPS6342230B2 JP S6342230 B2 JPS6342230 B2 JP S6342230B2 JP 54006993 A JP54006993 A JP 54006993A JP 699379 A JP699379 A JP 699379A JP S6342230 B2 JPS6342230 B2 JP S6342230B2
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- blood
- hemiglobin
- reaction
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 30
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 30
- 210000004369 blood Anatomy 0.000 claims abstract description 22
- 239000008280 blood Substances 0.000 claims abstract description 22
- 239000003599 detergent Substances 0.000 claims abstract description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 40
- 239000000243 solution Substances 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 33
- 229940109738 hematin Drugs 0.000 claims description 31
- BMUDPLZKKRQECS-UHFFFAOYSA-K 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid iron(3+) hydroxide Chemical compound [OH-].[Fe+3].[N-]1C2=C(C)C(CCC(O)=O)=C1C=C([N-]1)C(CCC(O)=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 BMUDPLZKKRQECS-UHFFFAOYSA-K 0.000 claims description 30
- 238000005375 photometry Methods 0.000 claims description 3
- 230000002949 hemolytic effect Effects 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000007795 chemical reaction product Substances 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000003595 spectral effect Effects 0.000 abstract description 3
- 239000012670 alkaline solution Substances 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 description 33
- 238000001228 spectrum Methods 0.000 description 9
- 238000005259 measurement Methods 0.000 description 7
- 230000035484 reaction time Effects 0.000 description 7
- 239000012086 standard solution Substances 0.000 description 7
- 108010003320 Carboxyhemoglobin Proteins 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 108010064719 Oxyhemoglobins Proteins 0.000 description 3
- 150000003278 haem Chemical class 0.000 description 3
- -1 potassium ferricyanide Chemical compound 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 108010044495 Fetal Hemoglobin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000011481 absorbance measurement Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical compound [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- YVDLFXBEBKPQGL-UHFFFAOYSA-M benzyl-(2,6-dimethylheptan-4-yl)-methyl-(2-phenoxyethoxy)azanium chloride Chemical compound [Cl-].C(C1=CC=CC=C1)[N+](C(CC(C)C)CC(C)C)(C)OCCOC1=CC=CC=C1 YVDLFXBEBKPQGL-UHFFFAOYSA-M 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 108010071981 cyanhemoglobin Proteins 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 108700026427 hemiglobincyanide Proteins 0.000 description 1
- 229940025294 hemin Drugs 0.000 description 1
- 108010036302 hemoglobin AS Proteins 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782803109 DE2803109A1 (de) | 1978-01-25 | 1978-01-25 | Verfahren und reagenz zur bestimmung des haemoglobingehaltes des blutes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54148595A JPS54148595A (en) | 1979-11-20 |
| JPS6342230B2 true JPS6342230B2 (US07968547-20110628-C00004.png) | 1988-08-22 |
Family
ID=6030310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP699379A Granted JPS54148595A (en) | 1978-01-25 | 1979-01-24 | Method and reagent for measuring homoglobin content of blood |
Country Status (13)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880749A (en) * | 1984-06-05 | 1989-11-14 | Eastman Kodak Company | Analytical element and its use in a whole blood hemoglobin assay |
| DE3582408D1 (de) * | 1984-12-06 | 1991-05-08 | Technicon Instr | Cyanidfreies haemoglobinreagens. |
| US4772561A (en) * | 1985-12-23 | 1988-09-20 | Miles Inc. | Test device and method of determining concentration of a sample component |
| US4800167A (en) * | 1987-04-10 | 1989-01-24 | Abbott Laboratories | Reagent and process for the determination of hemoglobin in blood |
| WO1988009504A1 (en) * | 1987-05-29 | 1988-12-01 | Toa Medical Electronics Co., Ltd. | Method for classifying leukocytes and reagents |
| JP2619900B2 (ja) * | 1988-01-27 | 1997-06-11 | 東亜医用電子株式会社 | 血液中の白血球およびヘモグロビンの測定用試薬および方法 |
| EP0729031A1 (en) * | 1995-02-24 | 1996-08-28 | F. Hoffmann-La Roche Ag | Set of reagents determining the content of total haemoglobin |
| DE19835243A1 (de) * | 1998-08-04 | 2000-02-24 | Lmb Technologie Gmbh | Vorrichtung und Verfahren zum Bestimmen eines Hämoglobinwerts von Blut |
| DE102005060993A1 (de) * | 2005-12-20 | 2007-06-28 | Medisynthana Diagnostics Gmbh & Co. Kg | Konversionsreagenz sowie Verfahren und Kit zur Bestimmung des Hämoglobins |
| US7560283B2 (en) * | 2006-01-27 | 2009-07-14 | Bio-Rad Laboratories, Inc. | Storage-stable cellular whole blood composition containing elevated amounts of D-dimer |
| US9826736B2 (en) * | 2010-08-12 | 2017-11-28 | Professional Disposables International, Inc. | Quaternary ammonium caprylyl glycol disinfectant wipes |
| CN112198265B (zh) * | 2020-03-16 | 2023-07-14 | 广州金域医学检验中心有限公司 | 用于同时检测血液类样本中多种类固醇激素的预处理方法、检测方法及试剂盒 |
| CN113008880A (zh) * | 2021-02-26 | 2021-06-22 | 必为(上海)医疗器械有限公司 | 一种医疗器械残留血检测套装及其使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1422881A (fr) * | 1963-08-16 | 1966-01-03 | Warner Lambert Pharmaceutical | Composition auxiliaire de diagnostic utilisable pour déterminer le cholestérol |
| BE790338A (fr) * | 1971-10-20 | 1973-04-20 | Mallinckrodt Chemical Works | Compositions reactives de recherche sur des echantillons biologiques, et leurs procedes de preparation et d'utilisation |
| US3847545A (en) * | 1972-05-18 | 1974-11-12 | Baxter Laboratories Inc | Diagnostic test for sickle-cell |
| US3964865A (en) * | 1975-01-30 | 1976-06-22 | Sigma Chemical Company | Lyophilized human hemoglobin standard for colorimetric determination of total hemoglobin |
| US4011045A (en) * | 1975-02-14 | 1977-03-08 | Bonderman Dean P | Turbidity reduction in triglyceride standards |
| US4050898A (en) * | 1976-04-26 | 1977-09-27 | Eastman Kodak Company | Integral analytical element |
| EP0010577B1 (de) * | 1978-11-01 | 1981-11-11 | Contraves Ag | Verfahren zur Verminderung der Störung einer photometrischen Messung durch Lichtstreuung in einer zu messenden Suspension und Reagenz zur Durchführung des Verfahrens |
| DE2850603A1 (de) * | 1978-11-22 | 1980-06-19 | Merck Patent Gmbh | Haemolysierloesung und verfahren zur haemolyse von blut |
-
1978
- 1978-01-25 DE DE19782803109 patent/DE2803109A1/de active Granted
-
1979
- 1979-01-19 NL NL7915009A patent/NL7915009A/nl not_active Application Discontinuation
- 1979-01-19 EP EP79100171A patent/EP0003340A3/de not_active Withdrawn
- 1979-01-19 GB GB8004473A patent/GB2052056B/en not_active Expired
- 1979-01-19 BE BEBTR47A patent/BE47T1/xx not_active IP Right Cessation
- 1979-01-19 CH CH339280A patent/CH646525A5/de not_active IP Right Cessation
- 1979-01-22 AT AT0043279A patent/AT367204B/de not_active IP Right Cessation
- 1979-01-24 ES ES477103A patent/ES477103A1/es not_active Expired
- 1979-01-24 JP JP699379A patent/JPS54148595A/ja active Granted
-
1980
- 1980-01-03 FR FR8000188A patent/FR2482729B1/fr not_active Expired
- 1980-03-31 SE SE8002469A patent/SE445681B/sv not_active IP Right Cessation
- 1980-04-01 IT IT86226/80A patent/IT1148290B/it active
- 1980-07-21 US US06/170,575 patent/US4341527A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE47T1 (fr) | 1980-03-21 |
| IT1148290B (it) | 1986-11-26 |
| DE2803109A1 (de) | 1979-07-26 |
| EP0003340A2 (de) | 1979-08-08 |
| SE8002469L (sv) | 1980-03-31 |
| SE445681B (sv) | 1986-07-07 |
| AT367204B (de) | 1982-06-11 |
| CH646525A5 (de) | 1984-11-30 |
| JPS54148595A (en) | 1979-11-20 |
| FR2482729B1 (fr) | 1987-05-07 |
| GB2052056B (en) | 1983-01-12 |
| IT8086226A0 (it) | 1980-04-01 |
| EP0003340A3 (de) | 1979-09-05 |
| DE2803109C2 (US07968547-20110628-C00004.png) | 1987-02-26 |
| FR2482729A1 (fr) | 1981-11-20 |
| US4341527A (en) | 1982-07-27 |
| NL7915009A (nl) | 1980-06-30 |
| GB2052056A (en) | 1981-01-21 |
| ATA43279A (de) | 1981-10-15 |
| ES477103A1 (es) | 1979-07-01 |
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