JPS6337631B2 - - Google Patents
Info
- Publication number
- JPS6337631B2 JPS6337631B2 JP11312484A JP11312484A JPS6337631B2 JP S6337631 B2 JPS6337631 B2 JP S6337631B2 JP 11312484 A JP11312484 A JP 11312484A JP 11312484 A JP11312484 A JP 11312484A JP S6337631 B2 JPS6337631 B2 JP S6337631B2
- Authority
- JP
- Japan
- Prior art keywords
- culture
- epoxide
- growth
- olefin
- batch culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001336 alkenes Chemical class 0.000 claims description 19
- 241000894006 Bacteria Species 0.000 claims description 18
- 238000004519 manufacturing process Methods 0.000 claims description 17
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 241000187654 Nocardia Species 0.000 claims description 11
- 241000186216 Corynebacterium Species 0.000 claims description 10
- 241000186146 Brevibacterium Species 0.000 claims description 7
- 230000005526 G1 to G0 transition Effects 0.000 claims description 7
- 230000001590 oxidative effect Effects 0.000 claims description 6
- 244000005700 microbiome Species 0.000 claims description 5
- 150000002118 epoxides Chemical class 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 description 27
- 150000002924 oxiranes Chemical class 0.000 description 24
- 230000012010 growth Effects 0.000 description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 239000007789 gas Substances 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000001569 carbon dioxide Substances 0.000 description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 4
- 235000011130 ammonium sulphate Nutrition 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000187561 Rhodococcus erythropolis Species 0.000 description 3
- 230000003698 anagen phase Effects 0.000 description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- NJWSNNWLBMSXQR-UHFFFAOYSA-N 2-hexyloxirane Chemical compound CCCCCCC1CO1 NJWSNNWLBMSXQR-UHFFFAOYSA-N 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11312484A JPS60259193A (ja) | 1984-06-04 | 1984-06-04 | 微生物によるエポキシド類の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11312484A JPS60259193A (ja) | 1984-06-04 | 1984-06-04 | 微生物によるエポキシド類の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60259193A JPS60259193A (ja) | 1985-12-21 |
| JPS6337631B2 true JPS6337631B2 (enrdf_load_stackoverflow) | 1988-07-26 |
Family
ID=14604132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11312484A Granted JPS60259193A (ja) | 1984-06-04 | 1984-06-04 | 微生物によるエポキシド類の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60259193A (enrdf_load_stackoverflow) |
-
1984
- 1984-06-04 JP JP11312484A patent/JPS60259193A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60259193A (ja) | 1985-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Biebl et al. | Glycerol conversion to 1, 3-propanediol by newly isolated clostridia | |
| Habets-Crützen et al. | Production of epoxides from gaseous alkenes by resting-cell suspensions and immobilized cells of alkene-utilizing bacteria | |
| US5164309A (en) | Process for the microbiological preparation of 1,3-propane-diol from glycerol by citrobacter | |
| JP2719340B2 (ja) | 発酵方法 | |
| JPH078235B2 (ja) | シュードグルコノバクター属酸化菌 | |
| Tanaka et al. | Production of poly-D-3-hydroxybutyric acid from carbon dioxide by a two-stage culture method employing Alcaligenes eutrophus ATCC 17697T | |
| US4535059A (en) | Muconic acid productivity by a stabilized mutant microorganism population | |
| US4657863A (en) | Stabilization of a mutant microorganism population | |
| IE920299A1 (en) | Microbiological process for the preparation of 6-hydroxypicolinic acid | |
| Malik et al. | Nitrogen fixation by the hydrogen-oxidizing bacterium Alcaligenes latus | |
| Stephan et al. | Denitrification by Azospirillum brasilense Sp 7: II. Growth with nitrous oxide as respiratory electron acceptor | |
| JPS6337631B2 (enrdf_load_stackoverflow) | ||
| EP0263403B1 (en) | Novel microorganism and method for producing oxygenous compounds with said microorganism | |
| JP2579595B2 (ja) | 新規微生物および該微生物を用いた２，６−ナフタレンジカルボン酸の製造法 | |
| CA1153971A (en) | Semi-continuous method for production of xanthan gum using xanthomonas campestris atcc 31601 | |
| JP3915505B2 (ja) | ε−ポリ−Ｌ−リジンの製造法 | |
| JPS6337632B2 (enrdf_load_stackoverflow) | ||
| US4328308A (en) | Semi-continuous method for production of xanthan gum using Xanthomanas campestris ATCC 31600 and Xanthomanas campestris ATCC 31602 | |
| JPS6337633B2 (enrdf_load_stackoverflow) | ||
| US4560657A (en) | Microbiological production of alkylene oxides | |
| CN100560728C (zh) | 2-kga的生产方法 | |
| US4328310A (en) | Semi-continuous method for production of xanthan gum using Xanthomonas campestris ATCC 31601 | |
| SU1752767A1 (ru) | Штамм бактерий RноDососсUS еRYтнRороLIS - продуцент эпоксидирующей монооксигеназы | |
| JPH06303967A (ja) | 新規微生物及びこれを用いるヌートカトンの製造法 | |
| US5962286A (en) | Process for the production of gluconic acid with a strain of Aureobasidium pullulans (de bary) Arnaud |