JPS6330284B2 - - Google Patents
Info
- Publication number
- JPS6330284B2 JPS6330284B2 JP58089067A JP8906783A JPS6330284B2 JP S6330284 B2 JPS6330284 B2 JP S6330284B2 JP 58089067 A JP58089067 A JP 58089067A JP 8906783 A JP8906783 A JP 8906783A JP S6330284 B2 JPS6330284 B2 JP S6330284B2
- Authority
- JP
- Japan
- Prior art keywords
- fucose
- present
- airway
- wheezing
- airway obstructive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract description 23
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims abstract description 18
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims abstract description 15
- 230000000414 obstructive effect Effects 0.000 claims abstract description 15
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 claims abstract description 14
- SHZGCJCMOBCMKK-SXUWKVJYSA-N alpha-L-fucose Chemical group C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-SXUWKVJYSA-N 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 208000037656 Respiratory Sounds Diseases 0.000 description 8
- 206010047924 Wheezing Diseases 0.000 description 8
- 108090001090 Lectins Proteins 0.000 description 7
- 102000004856 Lectins Human genes 0.000 description 7
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 7
- 239000002523 lectin Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 4
- 206010006451 bronchitis Diseases 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- 240000002853 Nelumbo nucifera Species 0.000 description 3
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 3
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002459 sustained effect Effects 0.000 description 3
- 101710186708 Agglutinin Proteins 0.000 description 2
- 101710146024 Horcolin Proteins 0.000 description 2
- 101710189395 Lectin Proteins 0.000 description 2
- 101710179758 Mannose-specific lectin Proteins 0.000 description 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108010041865 Ulex europaeus lectins Proteins 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 239000000910 agglutinin Substances 0.000 description 2
- 210000003651 basophil Anatomy 0.000 description 2
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 2
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 229940075420 xanthine Drugs 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 150000008481 L-fucoses Chemical class 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940041682 inhalant solution Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- -1 α-blocks Chemical compound 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58089067A JPS59216821A (ja) | 1983-05-23 | 1983-05-23 | 気道閉塞性障害治療・予防剤 |
| US06/611,068 US4612303A (en) | 1983-05-23 | 1984-05-17 | Therapeutic and/or preventive agent for obstructive respiratory diseases |
| AT84105879T ATE33099T1 (de) | 1983-05-23 | 1984-05-23 | Verwendung von l-fukose zur herstellung einer inhalationszusammensetzung und verfahren zur herstellung von l-fukose. |
| EP84105879A EP0129093B1 (en) | 1983-05-23 | 1984-05-23 | Use of l-fucose in the preparation of an inhalation composition and a process for preparing l-fucose |
| DE8484105879T DE3470002D1 (en) | 1983-05-23 | 1984-05-23 | Use of l-fucose in the preparation of an inhalation composition and a process for preparing l-fucose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58089067A JPS59216821A (ja) | 1983-05-23 | 1983-05-23 | 気道閉塞性障害治療・予防剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59216821A JPS59216821A (ja) | 1984-12-06 |
| JPS6330284B2 true JPS6330284B2 (enExample) | 1988-06-17 |
Family
ID=13960505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58089067A Granted JPS59216821A (ja) | 1983-05-23 | 1983-05-23 | 気道閉塞性障害治療・予防剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4612303A (enExample) |
| EP (1) | EP0129093B1 (enExample) |
| JP (1) | JPS59216821A (enExample) |
| AT (1) | ATE33099T1 (enExample) |
| DE (1) | DE3470002D1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59216821A (ja) * | 1983-05-23 | 1984-12-06 | Eisai Co Ltd | 気道閉塞性障害治療・予防剤 |
| GB9224956D0 (en) * | 1992-11-28 | 1993-01-20 | Euro Dpc Ltd | Improvements relating to allergen testing & apparatus |
| KR101098581B1 (ko) * | 2009-01-09 | 2011-12-26 | 서울대학교산학협력단 | Ａｂｈ 항원을 이용한 염증질환 개선용 조성물 |
| CN115381843B (zh) * | 2022-10-28 | 2023-01-10 | 四川大学华西医院 | L-岩藻糖在制备呼吸系统疾病治疗药物中的用途 |
| EP4442248A1 (en) * | 2023-04-05 | 2024-10-09 | PathoBlock Therapeutics GmbH & Co. KG | Compositions for use in treating infections |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240775A (en) * | 1962-07-30 | 1966-03-15 | Kelco Co | Preparation of alpha-l-fucosides and l-fucose from fucoidan |
| US4247540A (en) * | 1979-01-31 | 1981-01-27 | Gunter Holzmann | Therapeutic agent |
| JPS59216821A (ja) * | 1983-05-23 | 1984-12-06 | Eisai Co Ltd | 気道閉塞性障害治療・予防剤 |
-
1983
- 1983-05-23 JP JP58089067A patent/JPS59216821A/ja active Granted
-
1984
- 1984-05-17 US US06/611,068 patent/US4612303A/en not_active Expired - Lifetime
- 1984-05-23 AT AT84105879T patent/ATE33099T1/de active
- 1984-05-23 EP EP84105879A patent/EP0129093B1/en not_active Expired
- 1984-05-23 DE DE8484105879T patent/DE3470002D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0129093B1 (en) | 1988-03-23 |
| JPS59216821A (ja) | 1984-12-06 |
| EP0129093A1 (en) | 1984-12-27 |
| DE3470002D1 (en) | 1988-04-28 |
| US4612303A (en) | 1986-09-16 |
| ATE33099T1 (de) | 1988-04-15 |
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