JPS6328440B2 - - Google Patents

Info

Publication number
JPS6328440B2
JPS6328440B2 JP61315963A JP31596386A JPS6328440B2 JP S6328440 B2 JPS6328440 B2 JP S6328440B2 JP 61315963 A JP61315963 A JP 61315963A JP 31596386 A JP31596386 A JP 31596386A JP S6328440 B2 JPS6328440 B2 JP S6328440B2
Authority
JP
Japan
Prior art keywords
glu
obzl
val
boc
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP61315963A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62161799A (ja
Inventor
Wan Suusun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS62161799A publication Critical patent/JPS62161799A/ja
Publication of JPS6328440B2 publication Critical patent/JPS6328440B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP61315963A 1977-04-22 1986-12-29 ウンデカペプチド及びその製造方法 Granted JPS62161799A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US789898 1977-04-22
US871563 1978-01-23

Publications (2)

Publication Number Publication Date
JPS62161799A JPS62161799A (ja) 1987-07-17
JPS6328440B2 true JPS6328440B2 (enExample) 1988-06-08

Family

ID=25149025

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61315963A Granted JPS62161799A (ja) 1977-04-22 1986-12-29 ウンデカペプチド及びその製造方法

Country Status (5)

Country Link
US (1) US4116951A (enExample)
JP (1) JPS62161799A (enExample)
BE (1) BE866226A (enExample)
GB (1) GB1590669A (enExample)
HU (1) HU183945B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680276A (en) * 1977-05-25 1987-07-14 Institut National De La Sante Et De La Recherche Medicale Metal polypeptides
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
US4497801A (en) * 1982-09-17 1985-02-05 Fujisawa Pharmaceutical Co., Ltd. New peptides, process for preparation thereof and use thereof
US4504415A (en) * 1983-04-04 1985-03-12 Hoffman-La Roche Inc. Synthesis of thymosin α1 and desacetyl thymosin α1
US4517119A (en) * 1983-04-04 1985-05-14 Hoffmann-La Roche Inc. Synthesis of thymosin α1
US4983387A (en) * 1986-05-19 1991-01-08 Viral Technologies Inc. HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
USH1312H (en) 1992-05-28 1994-05-03 Cytogen Corporation Method for the preparation of gyk-dtpa
CN1058500C (zh) * 1993-02-03 2000-11-15 施塞克龙药品公司 胸腺素α－1衍生物
US6262230B1 (en) 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1
US5632983A (en) 1994-11-17 1997-05-27 University Of South Florida Method for treating secondary immunodeficiency
EP1007078A4 (en) * 1996-11-19 2002-11-13 Saulius Butenas PEPTIDOMIMETIC COMPOUNDS CONTAINING A 6-PEPTIDYLAMINO-1-NAPHTALENESULFONAMIDE GROUP
CA2950109C (en) 2000-10-27 2019-02-19 John W. Hadden Vaccine immunotherapy for immune suppressed patients
US20070154399A1 (en) * 2000-10-27 2007-07-05 Hadden John W Immunotherapy for immune suppressed patients
US20070031372A1 (en) * 2004-08-05 2007-02-08 Hadden John W Vaccine immunotherapy for immune suppressed patients
US20070025958A1 (en) * 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
US7182942B2 (en) * 2000-10-27 2007-02-27 Irx Therapeutics, Inc. Vaccine immunotherapy for immune suppressed patients
EP1446159A4 (en) * 2001-10-26 2005-06-01 Irx Therapeutics Inc IMMUNOTHERAPY FOR REVERSING AN IMMUNE UPPRESSION
CN1269524C (zh) * 2001-10-26 2006-08-16 罗得岛医院 胸腺素强化的遗传免疫方法
UA78726C2 (en) 2001-11-01 2007-04-25 Sciclone Pharmaceuticals Inc Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
UA77999C2 (en) * 2001-12-10 2007-02-15 Thymosin-alpha 1 for treatment of malignant glioblastoma
KR20050086819A (ko) 2002-11-25 2005-08-30 시클론 파마수티컬 인코포레이티드 알파 티모신을 사용한 방사능 손상에 대한 보호방법
CA2520400C (en) * 2003-03-28 2013-02-19 Sciclone Pharmaceuticals, Inc. Treatment of aspergillus infections with thymosin alpha 1
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
JP2007523878A (ja) * 2003-07-18 2007-08-23 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド 放射線被曝による損傷の処置または防止
US7993660B2 (en) 2007-11-28 2011-08-09 Irx Therapeutics, Inc. Method of increasing immunological effect
EP2429585B1 (en) 2009-05-15 2018-04-18 IRX Therapeutics, Inc. Vaccine immunotherapy
CN103097543A (zh) 2009-12-08 2013-05-08 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法
CN103694336B (zh) * 2013-10-30 2015-09-30 江苏施美康药业股份有限公司 一种固液相片段缩合制备胸腺肽α1的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077949A (en) * 1973-12-28 1978-03-07 Sloan-Kettering Institute For Cancer Research Polypeptide hormones of the thymus
US4079127A (en) * 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
CH641152A5 (en) * 1977-04-22 1984-02-15 Hoffmann La Roche Process for preparing thymosin alpha-1 and an analogue

Also Published As

Publication number Publication date
GB1590669A (en) 1981-06-03
US4116951A (en) 1978-09-26
BE866226A (fr) 1978-10-23
JPS62161799A (ja) 1987-07-17
HU183945B (en) 1984-06-28

Similar Documents

Publication Publication Date Title
JPS6328440B2 (enExample)
Rodriguez et al. Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin
US6255285B1 (en) Phenethylamine derivatives
JPH0662672B2 (ja) グリシン誘導体
US3842064A (en) Psychopharmacologically active tetra-,penta-,hexa-,and hepta-peptides
CA1267996A (en) Peptides which are active on the central nervous system and have an action on the cholinergic system
EP0348086B1 (en) Novel peptides, their use as immuno suppressants and processes for their preparation
JPS62228100A (ja) 硫酸エステル基を有するペプチド
CH636598A5 (de) Verfahren zur herstellung neuer psychopharmakologisch aktiver peptide.
US3856770A (en) Psychopharmacologically active tetra-, penta-, hexa-, and heptapeptides
AU684511B2 (en) Oligopeptides derived from C-reactive protein fragments
US3749703A (en) Asn15-bovine thyrocalcitonin
Hiskey et al. Sulfur-containing polypeptides. XV. Synthetic routes to the A6-13 segment of ovine insulin
CA1113088A (en) PROCESS FOR THE PREPARATION OF THYMOSIN .alpha..SUB.1 AND AN ANALOGUE
EP0161017B1 (en) Peptides
US3801561A (en) Derivatives of salmon thyrocalcitonin
EP0132919B1 (en) Peptides
US4238390A (en) Synthesis and biological activity of [D-Thr2, Δ3 Pro5 ]-enkephalinamide
US3272790A (en) Polypeptides
KR840000054B1 (ko) 티모신 α₁의 제조방법
CA1131217A (en) Psycho-pharmacological peptides
US4247543A (en) Organic compounds
Meldal Synthesis of a Putative Antigenic Heptapeptide from
CA1123428A (en) PROCESS FOR THE PREPARATION OF THYMOSIN .alpha..SUB.1 AND AN ANALOGUE
WO1986003495A2 (en) Derivatives of substances p and of fragments thereof