JPS6325565B2 - - Google Patents
Info
- Publication number
- JPS6325565B2 JPS6325565B2 JP11957381A JP11957381A JPS6325565B2 JP S6325565 B2 JPS6325565 B2 JP S6325565B2 JP 11957381 A JP11957381 A JP 11957381A JP 11957381 A JP11957381 A JP 11957381A JP S6325565 B2 JPS6325565 B2 JP S6325565B2
- Authority
- JP
- Japan
- Prior art keywords
- flubendazole
- liver
- drug
- liver fluke
- metacercariae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CPEUVMUXAHMANV-UHFFFAOYSA-N flubendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=C(F)C=C1 CPEUVMUXAHMANV-UHFFFAOYSA-N 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 24
- 229960004500 flubendazole Drugs 0.000 claims description 24
- 208000006275 fascioliasis Diseases 0.000 claims description 22
- 241000242711 Fasciola hepatica Species 0.000 claims description 21
- 241001465754 Metazoa Species 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 229940124597 therapeutic agent Drugs 0.000 claims description 9
- 230000003449 preventive effect Effects 0.000 claims description 7
- 229940079593 drug Drugs 0.000 description 14
- 235000013601 eggs Nutrition 0.000 description 11
- 210000000013 bile duct Anatomy 0.000 description 9
- 244000038280 herbivores Species 0.000 description 9
- 210000003608 fece Anatomy 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 241000282994 Cervidae Species 0.000 description 4
- 230000000507 anthelmentic effect Effects 0.000 description 4
- 230000017448 oviposition Effects 0.000 description 4
- 230000000069 prophylactic effect Effects 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 241000935974 Paralichthys dentatus Species 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 241000237858 Gastropoda Species 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000283977 Oryctolagus Species 0.000 description 2
- 208000030852 Parasitic disease Diseases 0.000 description 2
- 241001464377 Resia Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000015170 shellfish Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HYZJCKYKOHLVJF-SFIIULIVSA-N 1H-benzimidazole Chemical class C1=CC=C2N[11CH]=NC2=C1 HYZJCKYKOHLVJF-SFIIULIVSA-N 0.000 description 1
- 241000415078 Anemone hepatica Species 0.000 description 1
- 241000030939 Bubalus bubalis Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000204939 Fasciola gigantica Species 0.000 description 1
- 241001385463 Hepatica <moth> Species 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000242594 Platyhelminthes Species 0.000 description 1
- 241000242541 Trematoda Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- GGGATFRVOBEKQO-UHFFFAOYSA-N [3,5-dibromo-2-(2,4-dibromo-6-hydroxyphenyl)phenyl] dihydrogen phosphate Chemical compound OC1=CC(Br)=CC(Br)=C1C1=C(Br)C=C(Br)C=C1OP(O)(O)=O GGGATFRVOBEKQO-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- VHHHONWQHHHLTI-UHFFFAOYSA-N hexachloroethane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)Cl VHHHONWQHHHLTI-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
- 229950000975 salicylanilide Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11957381A JPS5821615A (ja) | 1981-07-29 | 1981-07-29 | 草食獣の肝蛭症の予防治療剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11957381A JPS5821615A (ja) | 1981-07-29 | 1981-07-29 | 草食獣の肝蛭症の予防治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5821615A JPS5821615A (ja) | 1983-02-08 |
| JPS6325565B2 true JPS6325565B2 (en, 2012) | 1988-05-26 |
Family
ID=14764685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11957381A Granted JPS5821615A (ja) | 1981-07-29 | 1981-07-29 | 草食獣の肝蛭症の予防治療剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5821615A (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT760648E (pt) * | 1994-05-20 | 2002-04-29 | Janssen Pharmaceutica Nv | Tabletes de flubendazole de mastigacao para animais domesticos |
| NZ515772A (en) * | 1999-06-04 | 2002-12-20 | Nufarm Ltd | Pesticidal emulsion composition containing levamisole in the aqueous phase and an anthelmintic in the organic phase |
| WO2000074489A1 (en) * | 1999-06-04 | 2000-12-14 | Nufarm Limited | Stable biocidal compositions |
| CN103301241B (zh) * | 2013-05-27 | 2014-10-08 | 王海华 | 一种治疗水生动物水蛭病的中草药及其制备方法 |
-
1981
- 1981-07-29 JP JP11957381A patent/JPS5821615A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5821615A (ja) | 1983-02-08 |
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