JPS63174928A - 注射用製剤 - Google Patents
注射用製剤Info
- Publication number
- JPS63174928A JPS63174928A JP686987A JP686987A JPS63174928A JP S63174928 A JPS63174928 A JP S63174928A JP 686987 A JP686987 A JP 686987A JP 686987 A JP686987 A JP 686987A JP S63174928 A JPS63174928 A JP S63174928A
- Authority
- JP
- Japan
- Prior art keywords
- aspoxicillin
- trihydrate
- injection
- pharmaceutical
- basic substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002347 injection Methods 0.000 title abstract description 17
- 239000007924 injection Substances 0.000 title abstract description 17
- 150000004684 trihydrates Chemical class 0.000 claims abstract description 23
- 239000000126 substance Substances 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims description 23
- 239000013078 crystal Substances 0.000 abstract description 10
- 239000000243 solution Substances 0.000 abstract description 10
- 239000000843 powder Substances 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 abstract description 2
- 230000002378 acidificating effect Effects 0.000 abstract description 2
- 239000003125 aqueous solvent Substances 0.000 abstract description 2
- 238000007796 conventional method Methods 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- BHELIUBJHYAEDK-OAIUPTLZSA-N Aspoxicillin Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3[C@H](C(C)(C)S[C@@H]32)C(O)=O)=O)NC(=O)[C@H](N)CC(=O)NC)=CC=C(O)C=C1 BHELIUBJHYAEDK-OAIUPTLZSA-N 0.000 abstract 6
- 229960000202 aspoxicillin Drugs 0.000 abstract 6
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 230000001747 exhibiting effect Effects 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 12
- 150000008064 anhydrides Chemical class 0.000 description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 239000007972 injectable composition Substances 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP686987A JPS63174928A (ja) | 1987-01-14 | 1987-01-14 | 注射用製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP686987A JPS63174928A (ja) | 1987-01-14 | 1987-01-14 | 注射用製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63174928A true JPS63174928A (ja) | 1988-07-19 |
| JPH053848B2 JPH053848B2 (fr) | 1993-01-18 |
Family
ID=11650239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP686987A Granted JPS63174928A (ja) | 1987-01-14 | 1987-01-14 | 注射用製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63174928A (fr) |
-
1987
- 1987-01-14 JP JP686987A patent/JPS63174928A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH053848B2 (fr) | 1993-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |