JPS6267027A - Dermal drug for external use - Google Patents

Abstract

PURPOSE:A dermal drug for external use containing an extract of a plant of the genus Isodon of the family Labiatae incorporated therein. CONSTITUTION:A dermal drug for external use, containing an extract obtained by heating leaves, stems or whole herb of a plant of the genus Isodon of the family Labiatae, e.g. Isodon japonicum Hara, Isodon trichocarpus Kudo or isodon kameba Okuyama, with a solvent, e.g. hot water or methanol, while refluxing, filtering the resultant extract, and concentrating the resultant extract in an amount of 0.0001-10wt.% preferably 0.001-5wt.% expressed in terms of solid material in the total dermal external drug and having improved effect on prevention of skin heat, skin roughening, barber's itch, inflammation, chilblain, swell in legs, vascular rise, etc. Various components, e.g. aqueous component, powder component, oil, surfactant, etc., used for cosmetics, quasi-drugs, medicines, etc., may be, as necessary, incorporated in addition to the above- mentioned essential component. The dosage form is solubilized system, e.g. toilet water, emulsified system, e.g. milky lotion, dispersion, ointment, foundation, etc.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention cures hot flashes, rough skin, razor burn, inflammation, chilblains, congestion, swelling of the legs, etc. by blending an extract of a plant of the Lamiaceae family, genus Yamahata. This invention relates to a topical skin preparation that is highly effective in preventing the appearance of blood vessels.

[Prior Art] Conventionally, various raw materials extracted from natural products, such as proteins, polysaccharides, extracted extracts, natural polymers, etc., have been incorporated into external skin preparations because of their distinctive effects. However, although there has been a long-awaited development of an external skin preparation that is highly effective in preventing hot flashes, razor burn, rough skin, etc. after sunburn, there has not yet been a sufficient supply of such preparations.

[Problems to be Solved by the Invention] In view of the above circumstances, the present inventors have conducted intensive research to obtain natural raw materials that have characteristic usefulness for the skin, and as a result, they have developed an extract of a plant of the genus Yamahata, family Lamiaceae. It was discovered that a skin external preparation containing the following is excellent in preventing hot flashes, rough skin, razor burn, inflammation, chilblains, congestion, swelling of the legs, floating blood vessels, etc., and thus completed the present invention. It's arrived.

[Means for Solving the Problems] That is, the present invention relates to a skin preparation for external use, which is characterized by containing an extract of a plant belonging to the Lamiaceae family and genus Yamahatu.

The configuration of the present invention will be explained in detail below.

Examples of the plants of the Lamiaceae genus Yamahata used in the present invention include Hikiokoshi, Kurobana Hikiokoshi, Kamebahikiokoshi, and the like.

The method for extracting the extract of a plant of the genus Yamahata of the Lamiaceae family used in the present invention is to use a solvent such as hot water, a lower alcohol such as methanol or ethanol, a hydrous lower alcohol, or propylene glycol to , an extract obtained by heating under reflux and filtration with an alcohol extract such as a polyhydric alcohol such as 1-3 butylene glycol or a water-containing polyhydric alcohol, or one or more organic solvents such as chloroform and ethyl acetate. Obtained by concentration.

In the present invention, the blending amount of the extract of a plant of the genus Yamahata of the family Lamiaceae is from 0.0001 to 0.0001 as a dry matter in the total amount of the skin external preparation.
10% by weight, preferably 0.001-5% by weight.

If it is less than 0.0001% by weight, the effect of the present invention cannot be fully exhibited, which is not preferable.

In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention may optionally include various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., i.e., aqueous ingredients, within the range that does not impair the effects of the present invention. Powder ingredients, oil, surfactants, humectants,
This means adding thickeners, preservatives, antioxidants, fragrances, coloring agents, drugs, etc. Moreover, the dosage form of the skin external preparation of the present invention is arbitrary, and can be, for example, a solubilized system such as a lotion, an emulsified system such as a milky lotion or a cream, or a dosage form such as a foundation, a dispersion, or an ointment. The effect of skin application was determined based on the vasoconstriction effect and the rate of relief from hot flashes, rough skin, razor burn, swelling of the legs, floating blood vessels, etc. on the skin in actual use tests.

(Method for measuring vasoconstriction effect) A vasoconstriction test, which is generally used as a method for determining swelling, was conducted. Remove the descending aorta from a domestic rabbit and create a helical specimen. This was carried out on a Tyrodet night at 37°C (
10+++1) and measured the isotropic contraction after dropping Namburu (0.1ml), and measured the 2X of N E (Norepinephrine) used as a pharmaceutical product.
The contraction effect was compared with that induced by a 10-8M ethanol solution, and the results are shown in Table 1.

The determination method is shown below.

(V; ] constant) 0: The contraction is larger than that induced by 2 x 10-8 Mol of NE.

○° ノ/n Same level △: Nol Horn Slightly weak ×; ノ/horn Almost no effect As is clear from Table 1, a very strong vasoconstrictor effect was observed in the Cucumber extract and the Clover extract.

Next, actual use tests were conducted to check for hot flashes, rough skin, razor burn, leg swelling, and bulging of blood vessels, etc., using the following test methods.

(Test method) The test was conducted by 20 testers each suffering from various symptoms such as hot flashes, rough skin, swelling of the legs, and bulging of blood vessels.Table 2
Apply the obtained lotion to the face, apply the lotion and
The roughness of the skin after a week was evaluated, and the lotion obtained from Table 2 was applied to the legs, and the swelling of the legs and the lifting of the blood vessels were evaluated for a comprehensive evaluation. The test was also conducted on 20 healthy male subjects, and each time after shaving, the lotion obtained from Table 2 was applied to examine the effect on shaving.

The results are shown in Table-3.

The judgment criteria are shown below.

(Criteria for determining hot flashes of the skin, rough skin, swelling of the legs, and raised blood vessels) Effectiveness: Hot flashes of the skin, rough skin after one week, swelling of the legs (
Now, the raised veins are almost no longer noticeable.

Effectively, the hot flashes on my skin, as well as the rough skin, swelling of my legs, and bulging of my blood vessels after one week, were significantly reduced.

Slightly effective - Hot flashes on the skin, rough skin after one week, swelling of the legs, and bulging of blood vessels were slightly reduced.

Ineffective: No change in skin hot flashes, rough skin, leg swelling, or bulging of blood vessels after one week.

(Criteria for razor sharpness) Significant effect: Razor stickiness after hair pricking was significantly improved.

Effective: Razor compatibility after hair pricking has been greatly improved.

Slightly effective: Slightly improved razor compatibility after hair pricking.

Invalid: There is no change in the razor blade after hair pricking.

(Judgment) 0: The percentage of test subjects who are markedly effective or effective (effective rate) is 8.
If it is 0% or more Q: Horn
When the horn (effective rate) is 50 to 80% ×: When the lno (effective rate) is 50% or less (blank below) Table 2 (blank below) Table 3 As is clear from Table 3, Hikiokoshi A product containing extracts of ``Kuropanahikikoshi'' and ``Kuropanahikikoshi'' was effective in improving hot flashes, rough skin, razor bumps, leg swelling, and bulging blood vessels.

EXAMPLE 1 Next, the present invention will be roughly explained in detail with reference to examples. However, the present invention is not limited to this. The blending amount is in weight%.

Example 1 Lotion water (1) Hikiokoshi leaf ethanol extract o, oos (2
) Glycerin 4.0 (30,3-
Butylene glycol 4.0(4) Ethanol
7.0 (5) Polyoxyethylene oleyl alcohol 0.5 (6) Methyl paraben 0.05 (7)
Citric acid 0.01(8) Sodium citrate 0.1(9) Flavoring
0.05 (10) Purified water
Residue (manufacturing method) Citric acid, sodium citrate, glycerin, purified water, 1.
Dissolve 3-butylene glycol. Separately, polyoxyethylene oleyl alcohol, fragrance, methylparaben, and Hikikosi extract were dissolved in ethanol, and this was added to the above-mentioned purified aqueous solution to solubilize and filtered to obtain a lotion.

Example 2 Cream (1) Cetostearyl alcohol 3.5 (2
) Squalane 40.0 (3)
Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6) Polyoxyethylene (20) Sorbitan monopalmitate ester
2.0(7) Stearic acid monoglyceride 2.
0(8) 50% ethanol extract of Hikiokoshi leaves and stems and 50% ethanol extract of Hikiokoshi leaves and stems 1.0(9) Fragrance 0.03(10)1
．． 3-Butylene glycol 5.0 (11)
Glycerin 5.0 (12) Purified water Residue (manufacturing method) (1) (2) (3) (4) (5) (6) (
7) Dissolve (8) and (9) by heating and keep at 75°C and add to (10), (11) and (12) heated to 75°C with stirring. After processing with a homomixer to make emulsified particles fine, the mixture was rapidly cooled while stirring to obtain cream.

Example 3 Emulsion (1) Ethanol extract of stems and leaves of Black-and-white violet 3.0 (2) Stearic acid 1.5 (3) Heptyl alcohol 0.5 (4) Beeswax
2.0 (5) Polyoxyethylene (10) Monooleic acid ester 1.0 (6) Glycerin monostearic acid ester 1.0 (7) Quince seed extract (5χ water soluble'e) 20
．． 0(8) Propylene glycol 5.0
(9) Ethanol 3.0 (1
0) Ethylparaben 0.3 (11
) Sodium hyaluronate 0.03 (12
) Purified water Residue (manufacturing method) Add a mixture of fragrance and ethanolic extract of Black Banana oleracea to ethanol and dissolve (alcohol phase).

Add propylene glycol to purified water and dissolve by heating.
Keep at °C (aqueous phase). Quince seed extract and other ingredients except sodium hyaluronate are mixed, heated and dissolved and kept at 70°C (oil phase). Pre-emulsify by adding the oil phase to the water phase and homogeneously emulsify using a homomixer. While stirring, add the alcohol phase, quinces seed extract, and sodium hyaluronate. Then, while stirring,
A milky lotion was obtained by cooling to ℃.

Example 4 Batter (1) Ethanol extract of Hikiokoshi leaves 0.5 (2)
Polyvinyl alcohol 15.0 (3) Polyethylene glycol 3.0 (4) Propylene glycol 7.0 (5) Ethanol
10.0(6) Methylparaben
0.05 (7) Fragrance
0.05(8) Purified water
Residue (manufacturing method) Add polyethylene glycol, propylene glycol, and methylparaben to purified water and stir to dissolve.

Next, polyvinyl alcohol was added and stirred with heating, and ethanol in which the fragrance had been dissolved and Hikikosi extract were added and dissolved with stirring to obtain a pack.

Example 5 Solid white powder (1) Talc 85.4 (
2) Stearic acid 1.5 (3)
Lanolin 5.0 (4) Squalane 5.0 (5) Sorbitan sesquioleate 2.0 (6) Triethanolamine 1.0 (7
) Hikiokoshi whole plant extract 0.001 (8)
Pigment Appropriate amount (8) Fragrance
Appropriate amount (manufacturing method) Thoroughly stir talc and pigment in a kneader (powder part).

Add triethanolamine to 50% equivalent amount of purified water7
Keep at 0°C (aqueous phase). Other ingredients except the fragrance are mixed, heated and dissolved and kept at 70°C (oil phase). The oil phase is added to the water phase and homogeneously emulsified using a homomixer, and this is added to the powder portion and kneaded using a kneader, after which water is evaporated and the mixture is processed using a pulverizer. While stirring the mixture well, spray the fragrance evenly and compression mold.

Example 6 Ointment (1) 50X ethanol extract of Hikiokoshi leaves and stems 0.1 (2) Stearyl alcohol 18.0 (3)
Mokuro 20.0 (4) Polyoxyethylene (10 mol) monooleic acid ester
0.25 (5) Glycerin monostearate 0.25 (6) Vaseline 40.0 (7) Purified water
21.4 (Production method) Keep purified water at 70°C (aqueous phase). Other components are mixed and dissolved at 70°C (oil phase). The oil phase was added to the water phase, uniformly emulsified using a homomixer, and then cooled to obtain an ointment.

When actually used, the cosmetics obtained from Examples 1 to 6 were found to have excellent effects on hot flashes, rough skin, leg swelling, chilblains, raised blood vessels, and razor burn.

Claims (1)

[Claims] A topical skin preparation containing an extract of a plant of the genus Yamaha of the Lamiaceae family.