JPS6258336B2 - - Google Patents
Info
- Publication number
- JPS6258336B2 JPS6258336B2 JP12126279A JP12126279A JPS6258336B2 JP S6258336 B2 JPS6258336 B2 JP S6258336B2 JP 12126279 A JP12126279 A JP 12126279A JP 12126279 A JP12126279 A JP 12126279A JP S6258336 B2 JPS6258336 B2 JP S6258336B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- propoxy
- carbostyryl
- pde
- phosphodiesterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims description 13
- 239000004480 active ingredient Substances 0.000 claims description 9
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 239000002220 antihypertensive agent Substances 0.000 claims description 2
- 229940030600 antihypertensive agent Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 27
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 20
- 125000005606 carbostyryl group Chemical group 0.000 description 18
- 239000003814 drug Substances 0.000 description 15
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- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 3
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- VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 description 3
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- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- GKPRCCPIFQAKNT-UHFFFAOYSA-M sodium acetate trihydrochloride Chemical compound [Na+].Cl.Cl.Cl.CC([O-])=O GKPRCCPIFQAKNT-UHFFFAOYSA-M 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- XHFLOLLMZOTPSM-UHFFFAOYSA-M sodium;hydrogen carbonate;hydrate Chemical compound [OH-].[Na+].OC(O)=O XHFLOLLMZOTPSM-UHFFFAOYSA-M 0.000 description 1
- JBJWASZNUJCEKT-UHFFFAOYSA-M sodium;hydroxide;hydrate Chemical compound O.[OH-].[Na+] JBJWASZNUJCEKT-UHFFFAOYSA-M 0.000 description 1
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- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
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- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12126279A JPS5645414A (en) | 1979-09-19 | 1979-09-19 | Phosphodiesterase inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12126279A JPS5645414A (en) | 1979-09-19 | 1979-09-19 | Phosphodiesterase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5645414A JPS5645414A (en) | 1981-04-25 |
| JPS6258336B2 true JPS6258336B2 (fr) | 1987-12-05 |
Family
ID=14806892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12126279A Granted JPS5645414A (en) | 1979-09-19 | 1979-09-19 | Phosphodiesterase inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5645414A (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
| DK167187A (da) * | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
| JPH07100648B1 (fr) * | 1990-01-08 | 1995-11-01 | ||
| WO1994014444A1 (fr) * | 1992-12-24 | 1994-07-07 | Otsuka Pharmaceutical Co., Ltd. | Remede contre le psoriasis |
| US20030045547A1 (en) * | 2001-05-02 | 2003-03-06 | Shinji Aki | Process for producing carbostyril derivatives |
| US20050101631A1 (en) | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
| US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
| ES2358324T3 (es) | 2002-09-10 | 2011-05-09 | Otsuka Pharmaceutical Co., Ltd. | Procedimiento para la producción de cilostazol. |
-
1979
- 1979-09-19 JP JP12126279A patent/JPS5645414A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5645414A (en) | 1981-04-25 |
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