JPS6248601A - Germicidal disinfectant - Google Patents

Abstract

PURPOSE:A germicidal disinfectant effectively showing disinfection power even in the presence of a high polymer retaining material, obtained by combining an alkylbenzyldimethylammonium with a cetyltrimethylammonium halide and/or a cetylpyridinium halide. CONSTITUTION:The titled disinfectant containing (A) 100pts.wt alkylbenzyldimethylammonium or its salt and (B) >=0.3pts.wt., preferably >=10pts. wt. cetyltriemethylammmonium halide (especially preferably bromide) and/or a cetylpyridinium halide (especially preferably chloride). Addition of the component B suppresses adsorption of the component A on a high polymer retaining material, an amount of an isolated substance of the component A is increased when the disinfectant is in contact with the high polymer retaining material and germicidal disinfection power is effectively shown.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a disinfectant containing an alkylbenzyldimethylammonium or a salt thereof, and a cetyltrimethylammonium halide or (and) a cetylpyridinium halide. . The basic rule is that it effectively exhibits sterilizing and disinfecting power even when it comes into contact with an object in the presence of a polymer support.

BACKGROUND OF THE INVENTION Alkylbenzyldimethylammonium chloride (also referred to as benzalkonium chloride, hereinafter rAB)
(sometimes abbreviated as DAcJ) has a colorless aqueous solution;
It is odorless and has antibacterial properties not only against Durham-positive and -negative bacteria but also against fungi, so it is useful as a sterilizing disinfectant (Japanese Pharmacopoeia, 10th revision, C-343, 1
981, floor bookstore). In addition, cetyltrimethylammonium halides (e.g., cetyltrimethylammonium bromide) and cetylpyridinium halides (e.g., cetylpyridinium chloride) are also known as compounds with bactericidal and disinfecting effects (edited by Kyosuke Tsuda and Hisashi Nogami; Pharmaceutical Design law (2
), Jidaishokan (1971), p. 429).

Problem to be solved by the invention Alkylbenzyldimethylammonium or a salt thereof;
For example, ABDAC aqueous solution is widely used as a sterilizing disinfectant, but when sterilizing and disinfecting by soaking a cellulose support such as absorbent cotton or gauze and wiping it, a phenomenon has been observed in which its sterilizing and disinfecting power decreases. . A similar decrease in sterilizing and disinfecting power is also observed in the case of holders prepared from synthetic polymeric materials such as rayon, polyurethane, silicone, etc. in addition to wool. For this reason, it is desired to develop a method for effectively exerting the sterilizing and disinfecting power of ABDAC even when using the above-mentioned polymer support.

Means for Solving the Problems In view of the above-mentioned situation, the present inventors investigated various causes of the decline in the above-mentioned sterilizing and disinfecting power, and found that ABDA
C is adsorbed to polymeric materials, and ABDAC in sterilizing disinfectant solution.
It was found that this is based on the fact that the amount of free substances is small.

Next, the present inventors conducted various studies on methods for suppressing the adsorption of ABDAC to polymer support bodies, and found that ABD
It was discovered that by allowing cetyltrimethylammonium bromide or (and) cetylpyridinium chloride to coexist in an AC aqueous solution, the amount of ABDAC released during contact with a polymer support was reduced, and after further research, the present invention was completed. did.

That is, the present invention is a disinfectant containing alkylbenzyldimethylammonium or a salt thereof, and cetyltrimedelammonium halide or (and) cetylpyridinium halide.

In the disinfectant of the present invention, the alkylbenzyldimethylammonium or its salt obtained by a conventional method is used, and chloride (ABDAC) is particularly advantageously used. A
The alkyl group constituting BDAC has 8 to I carbon atoms.
I can give you 8 things.

All of these are adsorbed to the polymer support, but in the present invention, among these, carbon number 12 has particularly strong sterilizing and disinfecting power.
or inhibition of adsorption of a component having 14 alkyl groups,
Or it can be effectively used for attachment and detachment.

Next, examples of the cetyltrimethylammonium halide include bromide and chloride, with bromide being particularly preferred. In addition, as cetylpyridinium halide,
Examples include chloride and bromide, with chloride being particularly preferred.

The disinfectant of the present invention contains 100% alkylbenzyldimethylammonium or a salt thereof. By containing halogenated cetyltrimethylammonium or (° and) halogenated cetylpyridinium in a proportion of about 0.3 parts by weight or more, preferably about 3 parts by weight or more, more preferably about 10 parts by weight or more, based on the It part. prepared. Such a quantitative ratio is effective in suppressing adsorption of alkylbenzyldimethylammonium or its salt to the polymer support. The adsorption suppressing effect becomes stronger as the amount of cetyltrimethylammonium halide or (and) cetylpyridinium halide is increased beyond the above-mentioned amount. The maximum amount may be used.

The formulation of the sterilizing disinfectant of the present invention is not particularly limited, and may be prepared into a solid formulation, liquid formulation, spray formulation, etc., for example, by a conventionally known method. In the case of liquids and sprays, water, alcohol, etc. can be used as a solvent.

Next, when using this disinfectant, the concentration of alkylbenzyldimethylammonium or its salt should be approximately 0.
．． 005 to 1% (weight/volume), in a solution state such that the concentration of cetyltrimethylammonium halide or (and) cetylpyridinium halide is approximately Q, 00:l to 0°4% (weight/volume). All you have to do is bring it into contact with the object to be sterilized. As the solvent at this time, water, alcohol (eg, ethanol), alcohol aqueous solution, etc. can be used, and the solvent may be appropriately selected in consideration of the type of object to be sterilized.

Conventionally known methods can be used to contact the object to be sterilized, such as dipping, spraying, sprinkling,
This can be done by washing, cleaning, wiping, etc. It can be applied to a wide variety of applications for the purpose of eliminating microbial contamination. For example, disinfection of medical purposes such as the affected parts of the human body, animals, various medical instruments and facilities, disinfection of hands, public facilities such as barbers and beauty salons, schools, houses, vehicles, tableware, food manufacturing factories and their manufacturing equipment, etc. It can be used for.

In particular, the sterilizing disinfectant of the present invention can be particularly advantageously used in an application method via a polymer carrier such as a cellulosic material, polyethylene, polyester, polyurethane, or silicone-based synthetic resin. A specific example of this application method is to soak gauze, purified absorbent cotton, non-woven fabric, etc. in this sterilizing disinfectant solution and use it as a medicine for disinfecting hands, affected areas, sterilizing skin, or mucous membranes, etc. Method: Absorbent cotton, purified absorbent cotton, non-woven fabric, wet towels, paper cotton, paper cloth, etc. are impregnated with this sterilizing disinfectant to clean and wipe the infant's skin and mouth, or to clean and wipe the nipples and breasts during breastfeeding, as well as the eyes. One method is to use it as a quasi-drug for cleaning and wiping the private parts and anus.

EXAMPLES The present invention will be explained in more detail with reference to Experimental Examples and Examples below.

Experimental example 1 C+tH□A B D A C, C14Ht s A
B D A C or CltHteA B D A C
and CI4Hts'A B D A C mixture (Clt
Purified absorbent cotton was immersed in each aqueous solution containing 0.01% of Hts form and 014Hte form (molar ratio 1:0.54) at a concentration of g/10 me and left at 25°C for 1 hour. The amount of ABDAC adsorbed onto purified absorbent cotton reached equilibrium. Next, cetyltrimethylammonium bromide (C1°TMAB) was added to the solution at various concentrations as shown in FIG. 1, and the concentration of ABDAC in the aqueous solution was determined by high performance liquid chromatography (HPLC).

This quantitative method was developed by Mayer [Journal of Pharmaceutical Sciences (J, Pharm, S
ci, 69), 1148 (1980)], using a Radial Pak 5CN column, detection wavelength λ254 nm, 0.1 M, pH 5.0 acetate buffer-acetonitrile (45:55), flow rate 2 d/sin. This method was used to quantify ABDAC.

FIG. 1 shows the relationship between the amount of Cl@T MA B added and the amount of each ABDAC released. As a result, the free ABDAC concentration already increased when C1, TMAB was added to O, 1 m@ol/12, and 95% of ABDAC was added when 5 m+sol/12 was added.
DAC was released.

Experimental example 2 C,! H□ or Cl4Hz. ABDAC 0.005
Ct * T M A 3 in an aqueous solution containing ~0.1%
3 was added at a concentration of 0 to 1 mmol/f2 to prepare aqueous solutions containing these in various proportions. Purified absorbent cotton was immersed in this aqueous solution at a ratio of g/10-, and the amount of each ABDAC released after adsorption equilibrium was measured in the same manner as in Experimental Example 1.

The results are shown in the second section for the case of C+tH□ABDAC.
and FIG. 3 shows the case of C I4HtsA B D AC.

As is clear from FIGS. 2 and 3, CI.

As the TMABa degree increases, the free ABDAC concentration increases, for example, C18C13T 1mm01/(l AB
D A Cili degree 0.005 to 0.1% Nioite Yu8 CI! HtsABDAC was 90% and free CI4HteA B DAC was 45-59%.

Experimental Example 3 ClzHtsABDAC, Ct-HtsABDAC or C, tHtsA B D A C and C14HtsA
B D A C mixture (CltHts body and 01.Ht
Cetylpyridinium chloride (C+5PC) was added to an aqueous solution containing 0.01% of the o-isomer (molar ratio 1:0.54).
were added as θ to lll1fflO1/Q to prepare aqueous solutions containing these in various proportions. Purified absorbent cotton was immersed in this aqueous solution at a concentration of g/10 −1, and the amount of ABDAC released after adsorption equilibrium was measured in the same manner as in Experimental Example 1. The results are shown in FIG. As is clear from FIG. 4, as the CI@PC concentration increases, the free ABDAC concentration increases, for example, C+@P
C1mmo1/Q is C+tHtsA B D A C
Free cttHxsA B D at concentration 0.01%
A C was 70%, free CI4HtsA B D AC was 37%, and the total amount of both inverse compounds was 59%.

Example 1 Approximately 0.7 g of paper cotton (cloth) measuring 10 cm long and 15 cm wide was coated with A.
BDAC (CltHtsABDAC: 67%, C+-
HtsABDAC: 29%, Cl1lH33ABDAC
:5%) 0.1%, CleTMAB O, 5 mmol
A disinfectant for hands is prepared by impregnating approximately 1.6 g of a sterilizing/disinfecting aqueous solution containing /f2 and sealing with aluminum foil.

Example 2 ABDAC (same composition as in Example 1) 0.02%.

C, ImmolzQ PC! Fill a manual spray container with a sterilizing and disinfecting aqueous solution containing
．． After spraying on 7g of absorbent cotton, it is placed in a packaging laminate film (polyethylene/polyester composite film) and heat sealed. This is sterilized with high pressure steam at 121° C. for 20 minutes to produce skin cleansing cotton.

Example 3 ABDAC (same composition as that of Example 1) 0 on an embossed paper towel of about 4.2 g, measuring 17cm+++ in length and 28.5cm in width.
．． 05%.

C. Impregnated with about 7.1 g of a sterilizing/disinfecting aqueous solution containing 0.2 mmol/ff of TMAB and sealing with a cellophane membrane to produce a sterilizing/disinfecting paper napkin.

Effects of the Invention The sterilizing disinfectant of the present invention can be widely applied to sterilizing and disinfecting various objects. In particular, even when used for sterilization through a polymer support, the sterilization and disinfection power of alkylbenzyldimethylammonium or its salt can be exerted blindly. That is, by coexisting halogenated tiltrimedelammonium or (and) halogenated cedylviridinium, adsorption of alkylbenzyldimethylammonium or its salt to the polymer support can be suppressed, As a result, the amount of free alkylbenzyldimethylammonium or its salt in the solution increases, and the objective of sterilizing and disinfecting power can be fully achieved.

[Brief explanation of the drawing]

Figure 1 shows that C+
e shows the small amount of ABDAC released when TMA B is added, and in the figure, -〇-1ic,,H,5ABDAC
In the case of , -〇- is C,, H,, ABDAC, -mu- is C,, If. ABDAC and CI4829A B
The case of a mixture of DACs is shown respectively. Figure 2 shows C
+d (tsA B D A C and C1, TMAB coexistence aqueous solution, Fig.
The ABDAC amounts of the four educts are shown when absorbent cotton is immersed in a coexisting aqueous solution of C and CIlClllT. In each figure, the curves indicated by the numbers 1゜2, 3.4, and 5 are C
+gTMAB is added at concentrations of 0.0.1.0.2.0.5 and 1 mmol/f2, respectively. Figure 4 shows the amount of ABDAC in the free form when absorbent cotton is immersed in a coexisting aqueous solution of ABDAC, C1, and PC. For C,,H,aABDAc, -mu is C,t Ht 5 A B D A C and C, d(ts
The case of a mixture of A B D A C is shown respectively. Engraving of drawings (no changes in content) $ 1 mouth C+6TMA8y x 10 mof/ 1 procedural amendment [Format] March 11, 1985

Claims (1)

[Claims] A sterilizing disinfectant containing alkylbenzyldimethylammonium or a salt thereof, and cetyltrimethylammonium halide or (and) cetylpyridinium halide.