JPS6245513A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To provide a dentifrice composition having little stimulation to the skin and mucosa and usable before meal without causing the change in the taste of food and drink, by using a polyglycerol fatty acid ester having an average polymerization degree of higher than a specific level as a cleaning foaming agent having high safety. CONSTITUTION:The objective dentifrice composition contains a polyglycerol fatty acid ester having an average polymerization degree of >=6, as a cleaning foaming agent. The polyglycerol fatty acid ester is preferably mono, id or triester of a polyglycerol having an average polymerization degree of especially 6-5,000, e.g. hexaglycerol, heptacontaglycerol, etc., and a 6-24C fatty acid such as caproic acid, palmitic acid, coconut fatty acid, etc. The surface tension of the dentifrice is lowered by high hydrophilicity and HLB of the ester. Since the ester has high permeability and frothability, it promotes the cleaning effect of the dentifrice and the dispersion and permeation of the active component, gives excellent foam in the mouth and is easily washed off with water.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to novel dentifrice compositions. Specifically, the present invention relates to a dentifrice composition containing polyglycerin fatty acid ester as a highly safe cleaning foaming agent.

(Field of Industrial Application) The dentifrice composition of the present invention has extremely low irritation to the skin and mucous membranes, and is particularly useful for cleaning the oral cavity, which requires the inclusion of a highly safe cleaning foaming agent. Polyglycerin fatty acid ester is a food additive with no restrictions on use, and is a very important emulsifier that creates a strong 0/W, W10 emulsifying system with excellent foaming power and has excellent salt resistance and acid resistance.

(Prior art) Surfactants used as cleaning foaming agents in toothpaste compositions have a cleaning effect on the toothpaste, promote the dispersion and penetration of the medicinal agents contained in the toothpaste, have a dispersion effect on the toothpaste itself, and create foam in the mouth due to foaming. It enhances properties such as spreading effect. Surfactants used in toothpaste include sodium alkyl sulfate,
Most of them are anionic surfactants such as sodium acylsarcosinate and α-olefin sulfonate.

U-Nroyl sarcosine sodium causes peeling of the oral mucosa when added at a concentration of 0.5% or more, and α-olefin sulfonate and sodium lauryl sulfate have some 1-1 effects on intraluminal mucosal irritation and have been added to toothpastes. There are problems such as inactivating enzymes. Furthermore, there is a problem in that the taste of food or drinks tastes different when ingested after brushing the teeth.

(Problem to be solved by the invention) On the other hand, nonionic surfactants are generally less irritating to the skin and mucous membranes than anionic surfactants, and are less likely to be inactivated by enzymes. . Nonionic surfactants that can be used for tooth brushing include sucrose fatty acid ester, polyoxyethylene sorbicun fatty acid ester, polyoxyethylene stearyl alcohol ether,
Examples include polyoxyethylene monofatty acid ester and polyoxyethylene sucrose fatty acid ester.

Sucrose fatty acid ester is a highly safe nonionic surfactant that is permitted as a food additive and has extremely low irritation to the skin and mucous membranes. Although it is widely used, there are still some safety issues.

(Means for Solving the Problem) As a result of intensive research aimed at developing a surfactant that has the role of a cleansing foaming agent for toothpaste and has excellent safety, the present inventors found that polyglycerin We have developed a toothpaste composition containing fatty acid ester as a cleansing foaming agent.

That is, the present invention is characterized by blending polyglycerin fatty acid ester, which is a food additive with excellent cleaning power and foaming power when used in toothpaste, is highly safe, and has no restrictions on use, as a foaming agent. shall be.

The polyglycerol fatty acid ester used in the present invention is
Average degree of polymerization 6~
5ooo polyglycerin fatty acid ester.

Fats used in polyglycerin fatty acid esters include caproic acid, capric acid, cabrinoic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, and coconut fatty acids with 6 to 24 carbon atoms. saturated or unsaturated, straight-chain or branched-chain fatty acids,
Among these, saturated or unsaturated, straight-chain or branched-chain fatty acids having 12 to 16 carbon atoms are preferred. These fatty acids may be used alone or in mixtures thereof.

The polyglycerin fatty acid ester of the present invention is a mono-, di-, tri-, tetra-, hepta-, hexa-, hepta-, octa-, nona-, or deca-mono fatty acid ester of polyglycerin having an average degree of polymerization of 6 to 5,000. , trifatty acid esters are preferred. These can be used alone or in mixtures.

Other toothpaste ingredients used in the present invention, i.e., as abrasives, calcium diphosphate, sodium metaphosphate,
Calcium carbonate, sodium silicate, magnesium carbonate, aluminum hydroxide, etc. are used. As the binder, sodium carboxymethylcellulose, methylcellulose, sodium alginate, carrageenan, gum arabic, gum tragacanth, bentonite, silicic anhydride, etc. are used. Wetting agents include glycerin, sorbitol, propylene glycol, polyethylene glycol,
Cyclodextrin and the like are used.

The dentifrice composition of the present invention contains medicinal agents such as fluoride, aluminum allantoinate, glycyrrhizinate, lysozyme, and salt, sweeteners such as saccharin sodium, sugar, and salt, preservatives, fragrances, and pigments. Can be blended.

(Function) The polyglycerin fatty acid ester of the present invention has an average degree of polymerization of 6
Because it is a polyglycerin fatty acid Nisdel with a polyglycerin content of ~5000, it is extremely hydrophilic, has a high HLB, lowers surface tension, and has large permeability and foaming power.
It promotes the cleaning effect when using toothpaste, promotes the dispersion and penetration of medicinal agents, the dispersion effect of toothpaste itself, and the spreading effect of foaming foam.

Next, the present invention will be explained by examples.

Example 1 Toothpaste was prepared in a conventional manner using the following prescription.

Ingredients Weight % Calcium diphosphate dihydrate 45.0 Carboxymebul cellulose 0.4 Carrageenan
0.6 glycerin
11.0 Sorbitol 9.0
water 30
．． 7 Decaglycerin monolaurate 2.1 Fragrance
0.9 Satucalin sodium 0.2 Preservatives
0.1 Example 2 A toothpaste was prepared according to a conventional method using the following formulation.

Ingredients Weight % Calcium carbonate 40.0 Carboxymethyl cellulose carrageenan 0.5 Glycerin 10.0 Sorbitol
10.0 water
3 0.7 triacontaglycerin monomyristate 2.5
Fragrance 1.0 Saccharin Sodium 0.2 Preservative
0.1 Example 3 Toothpaste was prepared according to the conventional method using the following recipe.

Ingredients Weight % Calcium diphosphate dihydrate 45.0 Carrageenan 1.0 Glycerin
10.0 Sorbitol
10.0 water
2 9.2 4 Doria kelp glycerin monopalm”Fh Fat m ester 1.5 Sodium metaphosphate 2.0 Fragrance
1.0 Ritsukarin Sodium 021X)j Melon)

0 0 3 Dextranase 0.
03 Example 4 Two tooth brushing tests were conducted by three male and two female volunteers using the toothpaste obtained in Example 1.2.3.
A questionnaire was conducted regarding the feeling of use (cleanliness, foaming) and the flavor of drinking orange juice after using the toothpaste. The results are shown in Table 1. We also conducted similar tests on commercially available toothpaste and presented the results.

(Effects of the present invention) Since the polyglycerin fatty acid ester, which is the cleaning foaming agent of the present invention, is a food additive with no restrictions on use, it causes almost no irritation to the skin and mucous membranes, and is safe.
Even if you accidentally drink it while brushing your teeth, there is no problem with the safety of the surfactant.

Furthermore, it has good cleaning effects, dispersion of medicinal agents, promotion of penetration, and foaming properties, is easy to rinse, and does not change the taste of food or juice after use.

Table 1 Tooth brushing test results

Claims (1)

[Claims] A dentifrice composition characterized by containing a polyglycerin fatty acid ester having an average degree of polymerization of 6 or more.