JPS6143327B2 - - Google Patents
Info
- Publication number
- JPS6143327B2 JPS6143327B2 JP52076020A JP7602077A JPS6143327B2 JP S6143327 B2 JPS6143327 B2 JP S6143327B2 JP 52076020 A JP52076020 A JP 52076020A JP 7602077 A JP7602077 A JP 7602077A JP S6143327 B2 JPS6143327 B2 JP S6143327B2
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- foaming
- toothpaste
- long chain
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 239000011734 sodium Substances 0.000 claims description 23
- 229910052708 sodium Inorganic materials 0.000 claims description 23
- 239000000606 toothpaste Substances 0.000 claims description 20
- 229940034610 toothpaste Drugs 0.000 claims description 19
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 18
- -1 acyl sodium glutamate Chemical compound 0.000 claims description 12
- 125000002252 acyl group Chemical group 0.000 claims description 5
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 4
- 239000003760 tallow Substances 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 239000004604 Blowing Agent Substances 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 125000005313 fatty acid group Chemical group 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 229940073490 sodium glutamate Drugs 0.000 claims 1
- 238000005187 foaming Methods 0.000 description 21
- 239000000551 dentifrice Substances 0.000 description 18
- 239000000796 flavoring agent Substances 0.000 description 8
- 239000004088 foaming agent Substances 0.000 description 8
- 235000019634 flavors Nutrition 0.000 description 7
- 229930195712 glutamate Natural products 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 150000004665 fatty acids Chemical group 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- NBDYSLCMCUDINP-UHFFFAOYSA-N 3-[dodecanoyl(methyl)amino]propanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)N(C)CCC(O)=O NBDYSLCMCUDINP-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid ester group Chemical group C(CCCCCCCCCCC)(=O)O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- QKHBMQWPOUUMQZ-BDQAORGHSA-M sodium;hydron;(2s)-2-(octadecanoylamino)pentanedioate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC([O-])=O QKHBMQWPOUUMQZ-BDQAORGHSA-M 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 229940092782 bentonite Drugs 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は歯磨組成物、さらに詳しくは、発泡剤
としてより安全性の高いN―長鎖アシルグルタミ
ン酸塩を用いる際の発泡性を改良した、かつ、歯
磨後の食物の味を変化させることなどない歯磨組
成物に関する。
歯磨組成物には清浄作用、分散乳化、発泡作用
などを付与するために発泡剤が配合されており、
界面活性剤がその目的で使用される。
発泡剤として用いられる界面活性剤は使用時の
歯磨の界面張力を低下させることによつて歯磨の
清浄効果を高め、配合されている薬効剤の分散浸
透性を促進してその効果を高めたり、使用時の発
泡により感覚的な安定感を与えるなどの役割を果
すもので必須の成分といえる。
これらの界面活性剤は界面張力低下能、発泡性
などの性能の良好なことはもちろん、歯磨は口の
中に入れるものであるから、味、においなどの点
を満足するものでなければならず、従来、アルキ
ル硫酸ナトリウム、アシルサルコシンナトリウ
ム、α―オレフインスルホネート、ココナツツモ
ノグリセリド硫酸ナリウムなどのアニオン界面活
性剤が用いられており、特にアルキル硫酸ナトリ
ウムは性能、味などの点ですぐれておりもつとも
一般的に用いられているが、これが舌の味蕾や口
腔粘膜に吸着されて起ると考えられる使用後の食
物の味を変えるという大きな欠点を有し、また、
若干の口腔粘膜刺激性、歯磨に薬効剤として配合
した酵素を不活性化するなどの問題がある。
一方、最近、これらの界面活性剤の安全性が問
題とされ、発泡剤としてより安全性の高い界面活
性剤を用いるべく種々の検討が加えられており、
その1つとしてN―長鎖アシルグルタミン酸塩を
歯磨に配合すことが提案されている(特公昭45―
24480号)。N―長鎖アシルグルタミン酸塩は毒性
がなく、皮膚や粘膜に対しての刺激がきわめて温
和であり、良好な洗浄力、発泡力、乳化力を有
し、耐硬水性がすぐれているなどの種々の特徴を
有し、歯磨組成物の発泡剤として非常に有効なも
のであるといわれいる。しかしながら、これを歯
磨組成物に配合すると、通常、歯磨組成物に配合
されているリン酸カルシウムや炭酸カルシウムの
ような多面カチオンを放出する基剤の影響を受
け、歯磨製造後の経日により極端に発泡力が低下
する現象を起し、商品価値を失つて実際上、かか
る歯磨組成物に配合することは非常に困難であ
る。
本発明者らは、より安全性の高い発泡剤を歯磨
組成物に配合するという見地から種々検討を行な
い、先に、モノフルオロリン酸ナトリウムおよ
び/またはポリリン酸塩をN―長鎖アシルグルタ
ミン酸塩と併用すると、前記のような基剤を用い
ても発泡力が低下しないことを見出し、すでに特
許出願した(特願昭51―026482号)。その後、さ
らに検討を重ねた結果、アシルサルコシンナトリ
ウムまたはN―アシル―N―メチル―β―アラニ
ンナトリウムをN―長鎖アシルグルタミン酸塩と
併用することによつても、用いる基材に影響さず
に、すぐれた発泡性を有する歯磨組成物が得られ
ることを見出した。
すなわち、本発明は、発泡剤としてN―長鎖ア
シルグルタミン酸塩とアシルサルコシンナトリウ
ムまたはN―アシル―N―メチル―β―アラニン
ナトリウムを配合した歯磨組成物を提供するもの
であり、本発明の歯磨組成物は発泡性が非常にす
ぐれ、従来のアルキル硫酸ナトリウムを配合した
歯磨組成物のような歯磨後に食物の味を変化させ
ることもなく、安全性の高いものである。
つぎの第1表にN―長鎖アシルグルタミン酸塩
とアシルサルコシンまたはN―アシル―N―メチ
ル―β―アラニンナトリウムを併用した練歯磨に
おける発泡性について試験した結果を示す。
試験は、N―長鎖アシルグルタミン酸塩とし
て、アシル基が硬化牛脂脂肪酸残基(炭素数14〜
18)のモノナトリウム塩、アシルサルコシンとし
てラウロイルサルコシン、N―アシル―N―メチ
ル―β―アラニンナトリウムとしてN―ラウロイ
ル―N―メチル―β―アラニンナトリウムを用
い、後記実施例1の処方に準じ、これらの配合量
を種々変化させて得られた歯磨組成物の起泡量、
量感を測定して行なつた。
起泡量は各々の歯磨試料5gをミキサーに入
れ、ついであらかめ30℃に加温した水150mlを投
じ60Vで90秒間撹拌後の泡の体積(ml)で示して
ある。量感はつぎのとおり評価した。
◎:泡立ち充分あり
〇:泡立ちあり
△:泡立ち少ない
×:泡立ちほとんどない
The present invention provides a dentifrice composition, more specifically, it has improved foaming properties when using a safer N-long chain acyl glutamate as a foaming agent, and does not change the taste of food after tooth brushing. The present invention relates to a dentifrice composition. Toothpaste compositions contain foaming agents to impart cleaning, dispersing, emulsifying, and foaming effects.
Surfactants are used for that purpose. Surfactants used as foaming agents increase the cleaning effect of toothpaste by lowering the interfacial tension of the toothpaste during use, promote the dispersion and penetration of the medicinal agents contained in the toothpaste, and increase its effectiveness. It can be said to be an essential ingredient as it plays a role such as providing a sense of stability through foaming during use. These surfactants must not only have good performance such as interfacial tension lowering ability and foaming properties, but also satisfy aspects such as taste and odor since toothpaste is something that is put in the mouth. Conventionally, anionic surfactants such as sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate, and sodium coconut monoglyceride sulfate have been used, and sodium alkyl sulfate in particular has excellent performance and taste, but is also generally used. However, it has the major disadvantage that it changes the taste of food after use, which is thought to be caused by adsorption to the taste buds of the tongue and oral mucosa.
There are problems such as slight irritation of the oral mucosa and inactivation of enzymes added as medicinal agents in toothpaste. On the other hand, recently, the safety of these surfactants has become a problem, and various studies have been conducted to use safer surfactants as foaming agents.
As one of these, it has been proposed to incorporate N-long chain acyl glutamate into toothpaste (Special Publication No. 1973-
No. 24480). N-long chain acyl glutamate is non-toxic, has very mild irritation to the skin and mucous membranes, has good cleaning power, foaming power, emulsifying power, and has excellent hard water resistance. It is said to have the following characteristics and is very effective as a foaming agent for dentifrice compositions. However, when this is added to a toothpaste composition, it is usually affected by the base that releases polyhedral cations such as calcium phosphate and calcium carbonate, which are included in the toothpaste composition, resulting in excessive foaming over time after the toothpaste is manufactured. In practice, it is very difficult to incorporate it into such dentifrice compositions because it causes a phenomenon of reduced strength and loses its commercial value. The present inventors conducted various studies from the viewpoint of incorporating a safer foaming agent into a dentifrice composition, and first, they added sodium monofluorophosphate and/or polyphosphate to N-long chain acylglutamate. It was discovered that the foaming power did not decrease when used in combination with the above-mentioned base, and a patent application has already been filed (Japanese Patent Application No. 51-026482). Subsequently, as a result of further studies, it was found that even when sodium acylsarcosinate or sodium N-acyl-N-methyl-β-alanine is used in combination with N-long chain acylglutamate, it does not affect the substrate used. It was discovered that a dentifrice composition having excellent foaming properties can be obtained. That is, the present invention provides a dentifrice composition containing N-long chain acyl glutamate and sodium acylsarcosine or sodium N-acyl-N-methyl-β-alanine as a foaming agent. The composition has excellent foaming properties, does not change the taste of food after tooth brushing unlike conventional dentifrice compositions containing sodium alkyl sulfate, and is highly safe. Table 1 below shows the results of testing the foaming properties of toothpastes using a combination of N-long chain acylglutamate and acylsarcosine or sodium N-acyl-N-methyl-β-alanine. The test was conducted using N-long chain acyl glutamate with acyl groups containing hydrogenated tallow fatty acid residues (14 to 14 carbon atoms).
18), using lauroylsarcosine as the acylsarcosine and N-lauroyl-N-methyl-β-alanine sodium as the N-acyl-N-methyl-β-alanine sodium, according to the recipe in Example 1 below, Foaming amount of dentifrice compositions obtained by varying these blending amounts,
This was done by measuring the volume. The amount of foaming is indicated by the foam volume (ml) after putting 5 g of each toothpaste sample into a mixer, then adding 150 ml of water warmed to 30°C and stirring at 60 V for 90 seconds. The volume was evaluated as follows. ◎: Sufficient foaming 〇: Foaming △: Little foaming ×: Almost no foaming
【表】
注〓*:重量%(以下同じ)
第1表から明らかなごとく、N―長鎖アシルグ
ルタミン酸モノナトリウム、ラウロイルサルコシ
ンナトリウム、N―ラウロイル―N―メチル―β
―アラニンナトリウム単独では殆んど起泡しない
がN―長鎖アシルグルタミン酸モノナトリウムと
ラウロイルサルコシンナトリウム又はN―ラウロ
イル―N―メチル―β―アラニンナトリウムを併
用すると発泡性が著しく向上することがわかる。
用いるアシルグルタミン酸塩としては、アシル
基が牛脂脂肪酸残基(炭素14〜18)のモノナトリ
ウム塩がもつとも発泡性が良好で好ましい。水溶
液における発泡性はアシル基がラウリン酸残基の
ものが最大であるが、該歯磨組成物においては発
泡性はあまり変らない。なお、アシルグルタミン
酸塩の配合割合は歯磨組成物の処方に応て適宜選
択されるが、通常、0.5〜3%の範囲が好まし
い。
また、用いるアシルサルコシンナトリウム、N
―アシル―N―メチル―β―アラニントナトリウ
ムとしては指肪酸残基がラウリン酸、ミリスチル
酸、パルミチン酸、ステアリン酸のものなどがあ
げられる。アシルサルコシンナトリウム、N―ア
シル―N―メチル―β―アラニンナトリウムとも
に、生体内にとり込まれても生体内で分解されて
脂肪酸とアミノ酸になるので安全性は高いが、ア
シルサルコシンナトリウムは0.5%以上、また、
N―アシル―N―メチル―β―アラニンナトリウ
ムの場合は0.75%以上用いると口腔内粘膜剥離を
生ずるので、これ以下の割合で配合することが好
ましい。
本発明の歯磨組成物は、歯磨粉、練歯磨、歯磨
軟膏、水歯磨などの通常の剤形のものをすべて包
含する。また、他の配合成分は通常、歯磨組成物
に用いられるものでよく、例えば、粘結剤として
カルボキシメチルセルロースナトリウム、カラギ
ーナン、アルギン酸ナトリウム、ベントナイト、
無水ケイ酸など、湿潤剤として、グリセリン、ソ
ルビトール、プロピレングリコール、ピロリドン
カルボン酸ナトリウム、ポリエチレングリコール
研摩剤として、第二リン酸カルシウム(二水化
物、無水物)、炭酸カルシウム、ケイ酸塩、不溶
性メタリン酸ナトリウム、水酸化アルミニウム、
ピロリン酸カルシウムなどが用いられる。
また、本発明の歯磨組成物には種々の薬効剤を
配合してもよく、かかる薬効剤としてはアルミニ
ウムアラントイネート、グリチルリチン酸塩、ク
ロルヘキシジン、ヒノキチオール、デキストラナ
ーゼ、リゾチーム、食塩、トラネキサム酸、ε―
アミノカプロン酸などがあげられる。
本発明によれば、前記のごとく、安全性のより
高い発泡剤を配合した、発泡性の著るしくすぐ
れ、使用後において食物の味を変化させることの
ない歯磨組成物が得られる。
つぎに実施例をあげ、本発明をさらに詳しく説
明するが、これらに限定されるものではない。
実施例 1
つぎの処方により、常法につて練歯磨を調製し
た。
成分 %
炭酸カルシウム 40.00
カルボキシメチルセルロース 0.50
カラギーナン 0.50
グリセリン 13.00
ソルビトール 7.00
無水ケイ酸 1.50
水 33.90
N―長鎖アシルグルタミン酸ナトリウ
ム(味の素(株)製、アミソフトHS―11、
アシル基:炭素数14〜18の硬化牛脂脂
肪酸残基) 2.00
殺菌剤、防腐剤 0.10
ラウロイルサルコシンナトリウム 0.50
香料 1.00
実施例 2
つぎの処方により、常法に従つて練歯磨を調製
した。
成分 %
第二リン酸カルシウム・二水化物 45.00
カルボキシメチルセルロース 0.50
カラギーナン 0.50
グリセリン 10.00
ソルビトール 10.00
水 30.05
N―長鎖アシルグルタミン酸ナトリウ
ム(味の素(株)製、アミソフトHS―11) 2.00
サツカリンナトリウム 0.10
殺菌剤、防腐剤 0.10
N―ラウロイル―N―メチル―β―ア
ラニンナトリウム 0.75
香料 1.00
前記実施例1の歯磨組成物を用いて「オレンジ
ジユース効果」(歯磨使用後に酸味の強い食物、
代表的にはオレンジジユースを飲むと味が非常に
変わつて感じられる現象、特公昭47―43830号参
照)について試験した。試験は対照として実施例
1の組成物中、N―長鎖アシルグルタミン酸ナト
リウムとラウロイルサルコシンナリウムをラウリ
ル硫酸ナトリウム(2%)にかえた組成物(参考
例)を用い、5人の専用パネルにより歯磨使用後
に飲んだオレンジジユースの風味についてつぎの
とおり評価した。
0:風味変化なし、1:風味ほとんど変化な
し、2:やや風味が変化する、3:相当風味が変
化する、4:非常に風味が変化する。
つぎの第2表に結果を示す。[Table] Note: *: Weight% (same below)
As is clear from Table 1, monosodium N-long chain acylglutamate, sodium lauroyl sarcosine, N-lauroyl-N-methyl-β
- Sodium alanine hardly foams alone, but when monosodium N-long chain acylglutamate and sodium lauroyl sarcosine or sodium N-lauroyl-N-methyl-β-alanine are used in combination, foaming properties are significantly improved. The acyl glutamate to be used is preferably a monosodium salt of beef tallow fatty acid residue (carbon 14-18) having an acyl group since it has good foaming properties. The foaming property in an aqueous solution is greatest when the acyl group is a lauric acid residue, but the foaming property does not change much in the dentifrice composition. The blending ratio of acylglutamate is appropriately selected depending on the formulation of the dentifrice composition, but is usually preferably in the range of 0.5 to 3%. In addition, the acylsarcosine sodium used, N
Examples of sodium -acyl-N-methyl-β-alaninate include those in which fatty acid residues are lauric acid, myristic acid, palmitic acid, and stearic acid. Both acylsarcosine sodium and N-acyl-N-methyl-β-alanine sodium are highly safe because they are broken down into fatty acids and amino acids even if taken into the body, but acylsarcosine sodium has a concentration of 0.5% or more. ,Also,
In the case of N-acyl-N-methyl-β-alanine sodium, if it is used in an amount of 0.75% or more, oral mucosal peeling will occur, so it is preferably blended in a proportion less than this. The dentifrice composition of the present invention includes all conventional dosage forms such as toothpaste, toothpaste, dentifrice ointment, and water dentifrice. In addition, other ingredients may be those normally used in dentifrice compositions, such as sodium carboxymethyl cellulose, carrageenan, sodium alginate, bentonite, etc. as a binder.
As a wetting agent, such as silicic anhydride, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol as an abrasive, dibasic calcium phosphate (dihydrate, anhydride), calcium carbonate, silicate, insoluble sodium metaphosphate , aluminum hydroxide,
Calcium pyrophosphate etc. are used. In addition, various medicinal agents may be added to the dentifrice composition of the present invention, and such medicinal agents include aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, salt, tranexamic acid, ε-
Examples include aminocaproic acid. According to the present invention, as described above, it is possible to obtain a dentifrice composition that contains a foaming agent with higher safety, has extremely good foaming properties, and does not change the taste of food after use. Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto. Example 1 A toothpaste was prepared in a conventional manner according to the following formulation. Ingredients % Calcium carbonate 40.00 Carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 33.90 Sodium N-long chain acyl glutamate (manufactured by Ajinomoto Co., Ltd., Amisoft HS-11, Acyl group: Hardened beef tallow with 14 to 18 carbon atoms) Fatty acid residue) 2.00 Bactericide, preservative 0.10 Sodium lauroyl sarcosine 0.50 Flavoring agent 1.00 Example 2 A toothpaste was prepared according to the conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 45.00 Carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 30.05 Sodium N-long chain acylglutamate (manufactured by Ajinomoto Co., Inc., Amisoft HS-11) 2.00 Satucalin sodium 0.10 Bactericide, preservative 0.10 N-lauroyl-N-methyl-β-alanine sodium 0.75 Fragrance 1.00 Using the toothpaste composition of Example 1, the "orange youth effect" (after using toothpaste, acidic foods,
A typical example of this was the phenomenon in which the taste of orange juice appears to change significantly (see Special Publication No. 47-43830). The test was conducted by a dedicated panel of five people using a composition (reference example) in which sodium N-long chain acylglutamate and lauroyl sarcocinnarium were replaced with sodium lauryl sulfate (2%) in the composition of Example 1 as a control. The flavor of orange juice taken after using toothpaste was evaluated as follows. 0: No change in flavor, 1: Almost no change in flavor, 2: Slight change in flavor, 3: Significant change in flavor, 4: Significant change in flavor. The results are shown in Table 2 below.
【表】
第2表より明らかなごとく、本発明の歯磨組成
物は、使用後の食物の風味をほとんど変化させる
ことがない。[Table] As is clear from Table 2, the dentifrice composition of the present invention hardly changes the flavor of food after use.
Claims (1)
基(炭素数14〜18)のN―長鎖アシルグルタミン
酸ナトリウム0.5〜3重量%と、ラウロイルサル
コシンナトリウム0.5重量%以下またはN―ラウ
ロイル―N―メチル―β―アラニンナトリウム
0.75重量%以下を配合したことを特徴とする歯磨
組成物。1 As a blowing agent, 0.5 to 3% by weight of N-long chain acyl sodium glutamate whose acyl group is a hardened tallow fatty acid residue (14 to 18 carbon atoms) and 0.5% by weight or less of sodium lauroyl sarcosine or N-lauroyl-N-methyl. -β-alanine sodium
A toothpaste composition characterized by containing 0.75% by weight or less.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7602077A JPS5411242A (en) | 1977-06-24 | 1977-06-24 | Tooth paste composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7602077A JPS5411242A (en) | 1977-06-24 | 1977-06-24 | Tooth paste composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5411242A JPS5411242A (en) | 1979-01-27 |
JPS6143327B2 true JPS6143327B2 (en) | 1986-09-26 |
Family
ID=13593134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7602077A Granted JPS5411242A (en) | 1977-06-24 | 1977-06-24 | Tooth paste composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5411242A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0526183Y2 (en) * | 1987-11-24 | 1993-07-01 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6059982B2 (en) * | 1980-12-09 | 1985-12-27 | 昭和アルミニウム株式会社 | Method for manufacturing aluminum foil for electrolytic capacitor electrodes |
JPS59918A (en) * | 1982-06-25 | 1984-01-06 | 住友軽金属工業株式会社 | High purity aluminum foil for electrolytic condenser and method of producing same |
FR2705673B1 (en) * | 1993-05-25 | 1995-07-28 | Givaudan Lavirotte | Compositions comprising amino acid derivatives, processes for their preparation and their uses. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5053545A (en) * | 1973-09-14 | 1975-05-12 |
-
1977
- 1977-06-24 JP JP7602077A patent/JPS5411242A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5053545A (en) * | 1973-09-14 | 1975-05-12 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0526183Y2 (en) * | 1987-11-24 | 1993-07-01 |
Also Published As
Publication number | Publication date |
---|---|
JPS5411242A (en) | 1979-01-27 |
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